25 patents
Utility
Compositions and methods for generating hair cells by downregulating FOXO
4 Apr 23
Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
Christopher Loose, Will McLean, Megan Harrison, Melissa Hill-Drzewi
Filed: 19 Aug 19
Utility
QUINOLIN-4-ONE and 4(1H)-CINNOLINONE Compounds and Methods of Using Same
23 Feb 23
The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Bradley TAIT, Megan S. HARRISON, Will MCLEAN
Filed: 7 Feb 20
Utility
Compositions and Methods for Generating Hair Cells by Upregulating JAG-1
18 Aug 22
Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
Christopher LOOSE, Will MCLEAN, Megan S. HARRISON
Filed: 24 Sep 21
Utility
Pharmaceutical Compositions Comprising Otic Therapeutic Agents and Related Methods
23 Jun 22
The present disclosure relates to pharmaceutical compositions (e.g., pre-lyophilized pharmaceutical compositions, lyophilized pharmaceutical compositions, and reconstituted solutions) comprising one or more otic therapeutic agents.
Will MCLEAN, Rajesh MANCHANDA, Snehal KHEDKAR, Richard A. STRONG, Jr., Ashley BANKS, Bradley TAIT, Christopher LOOSE
Filed: 2 Oct 19
Utility
Combination of CHIR99021 and Valproic Acid for Treating Hearing Loss
9 Jun 22
Provided herein are compound(s) for use in treating sensorineural hearing loss in a human patient, for example, hair cell regeneration agent(s) for use in treating sensorineural hearing loss in a human.
Carl LEBEL, Jenna HERBY, Will MCLEAN, Ashley HINTON, Moraye BEAR, Christopher LOOSE
Filed: 8 Apr 20
Utility
Taz Activators and WNT Agonists for Treating Ear Disorders
26 May 22
Provided are compositions and methods comprising a TAZ activator and a Wnt agonist for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating inner ear hearing or balance disorders.
Will MCLEAN, Megan S. HARRISON, Bradley TAIT
Filed: 7 Feb 20
Utility
Valproic Acid Compounds and WNT Agonists for Treating Ear Disorders
5 May 22
The present invention provides methods for treating diseases and disorders of the ear with valproic acid compounds and Wnt agonists.
Will MCLEAN, Christopher LOOSE
Filed: 7 Feb 20
Utility
Compositions and Methods for Generating Hair Cells by Inhibiting Epigenetic Targets
28 Apr 22
Provided are compositions and methods comprising an epigenetic agent and a Wnt agonist for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating inner ear hearing or balance disorders.
Will MCLEAN, Megan HARRISON, Melissa HILL-DRZEWI, Bradley TAIT
Filed: 7 Feb 20
Utility
Thermoreversible Compositions for Administration of Therapeutic Agents
31 Mar 22
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Christopher LOOSE, Will MCLEAN, Megan HARRISON, Michael R. JIROUSEK
Filed: 1 Oct 21
Utility
Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
1 Mar 22
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Christopher Loose, Will Mclean, Megan Harrison, Michael R. Jirousek
Filed: 2 Mar 17
Utility
Thermoreversible compositions for administration of therapeutic agents
2 Nov 21
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Filed: 4 Jan 19
Utility
Compositions and methods for generating hair cells by upregulating JAG-1
2 Nov 21
Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
Christopher Loose, Will McLean, Megan Harrison
Filed: 19 Aug 19
Utility
1H-PYRROLE-2,5-DIONE Compounds and Methods of Using Them to Induce Self-renewal of Stem/progenitor Supporting Cells
30 Sep 21
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
Filed: 3 Jun 21
Utility
Solubilized Compositions for Controlled Proliferation of Stem Cells / Generating Inner Ear Hair Cells Using GSK3 Inhibitors: I
26 Aug 21
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Christopher LOOSE, Will MCLEAN, Megan S. HARRISON, Michael R. JIROUSEK
Filed: 12 May 21
Utility
1H-pyrrole-2,5-dione compounds and methods of using same
20 Jul 21
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Christopher Loose, Bradley Tait, Rajesh Manchanda, Will Mclean
Filed: 21 Dec 17
Utility
Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: I
15 Jun 21
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Filed: 20 Dec 18
Utility
Methods for Controlled Proliferation of Stem Cells / Generating Inner Ear Hair Cells Using 2-PYRIMIDINYLAMINOETHYLAMINO-2-PYRIDYL Based Compounds
1 Apr 21
Christopher LOOSE, Will MCLEAN, Melissa HILL-DRZEWI
Filed: 12 May 20
Utility
1,2-DIHYDRO-3H-PYRAZOL-3-ONE Compounds and Methods of Using Same
7 Oct 20
The present disclosure relates to 1,2-dihydro-3H-pyrazol-3-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
Filed: 20 Dec 18
Utility
Methods for Hair Follicle Stem Cell Proliferation
22 Apr 20
The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN, Megan HARRISON, Sara STRECKER
Filed: 16 Oct 19
Utility
Methods for Hair Follicle Stem Cell Proliferation
15 Apr 20
The present invention relates to compositions of Sonic Hedgehog (Shh) pathway activators and Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN, Megan S. HARRISON, Sara STRECKER
Filed: 10 Apr 18