20 patents
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
11 Jan 24
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Filed: 30 Aug 23
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
21 Dec 23
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Filed: 30 Aug 23
Utility
Anti-vegf Antibody Constructs and Related Methods for Treating Vestibular Schwannoma Associated Symptoms
21 Sep 23
The present disclosure provides a construct comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a vascular endothelial growth factor (VEGF) binding agent or a portion thereof.
Emmanuel John Simons, Robert Ng, Michael McKenna
Filed: 13 Apr 23
Utility
Compositions and Methods for Treating KCNQ4-ASSOCIATED Hearing Loss
6 Jul 23
The present disclosure provides technologies comprising a polynucleotide capable of expressing and/or inhibiting a KCNQ4 gene product.
Emmanuel John Simons, Robert Ng, Linda B. Couto, Gregory Scott Robinson, Katherine Diane Gribble
Filed: 12 May 21
Utility
Compositions and Methods for Treating SLC26A4-ASSOCIATED Hearing Loss
29 Jun 23
The present disclosure provides constructs comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a pendrin protein.
Emmanuel John Simons, Robert Ng, Yen-Fu Cheng
Filed: 12 May 21
Utility
Devices, Systems, and Methods for Delivering Fluid to the Inner Ear
29 Jun 23
A device (10) to deliver fluid to an ear includes: a handle portion (12) including a proximal end and a distal end; a needle sub-assembly (26) coupled to the distal end of the handle portion (12) and including a bent needle (38); and tubing (36) coupled to the proximal end of the handle portion (12).
Michael McKenna, John Connelly
Filed: 26 May 21
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
6 Apr 23
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John SIMONS, Robert NG
Filed: 29 Jul 22
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
23 Mar 23
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Filed: 2 Sep 22
Utility
Use of Adeno-associated Viral Vectors to Correct Gene Defects/ Express Proteins In Hair Cells and Supporting Cells In the Inner Ear
23 Feb 23
Provided herein are compositions that include at least two different nucleic acid vectors that, when introduced into a primate cell, the at least two different vectors undergo con catamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length target protein (e.g., a supporting cell target protein or a hair cell target protein).
Emmanuel John Simons, Robert Ng, Danielle R. Lenz, Michelle Valero
Filed: 7 Nov 19
Utility
Compositions and Methods of Inducing Differentiation of a Hair Cell
15 Dec 22
Provided herein are compositions that include one or more adeno-associated virus (AAVs) vectors and methods of inducing differentiation of a hair cell using these vector(s).
Emmanuel John Simons, Robert Ng, Danielle R. Lenz, Michelle Valero
Filed: 7 Nov 19
Utility
Methods of Treating Hearing Loss Using a Secreted Target Protein
15 Dec 22
Provided herein are compositions that include a single nucleic acid vector or two different nucleic acid vectors, and the use of these compositions to treat hearing loss in a subject.
Emmanuel J. Simons, Robert Ng, Danielle R. Lenz, Hao Chiang
Filed: 24 Jul 20
Utility
Aav-mediated Delivery of Therapeutic Antibodies to the Inner Ear
25 Aug 22
Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
Emmanuel John Simons, Robert Ng, Michael McKenna
Filed: 17 Mar 22
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
10 Feb 22
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Robert Ng, Ellen Reisinger, Hanan Al-Moyed, Sebastian Kügler
Filed: 8 Apr 21
Utility
a Method for Treating an Auditory Neuropathy Spectrum Disorder
6 Jan 22
The present invention provides a method for treating an auditory neuropathy spectrum disorder in a subject comprising transferring the gene of DFNB59 via an adeno-associated virus (AAV) vector to the subject.
Yen-Fu Cheng, Chen-Chi Wu, Ying-Chang Lu
Filed: 27 Sep 19
Utility
Aav-mediated Delivery of Therapeutic Antibodies to the Inner Ear
25 Nov 21
Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
Emmanuel John Simons, Robert Ng, Michael McKenna
Filed: 3 Aug 21
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
25 Nov 21
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Filed: 16 Jul 21
Utility
Methods of Treating Non-syndromic Sensorineural Hearing Loss
28 Oct 21
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of a stereocilin protein, and the use of these compositions to treat non-syndromic sensorineural hearing loss in a subject.
Emmanuel John Simons, Robert Ng
Filed: 12 Jul 19
Utility
Methods of Treating CLRN1-ASSOCIATED Hearing Loss And/or Vision Loss
9 Sep 21
Provided herein are compositions that include a single nucleic acid vector or two different nucleic acid vectors, and the use of these compositions to treat hearing loss and/or vision loss in a subject.
Emmanuel John Simons, Robert Ng
Filed: 25 Jun 19
Utility
Aav-mediated Delivery of Therapeutic Antibodies to the Inner Ear
11 Mar 21
Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
Emmanuel John Simons, Robert Ng, Michael McKenna
Filed: 19 Dec 18
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
16 Dec 20
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Robert Ng, Ellen Reisinger, Hanan Al-Moyed, Sebastian Kügler
Filed: 21 Feb 19
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