573 patents
Utility
Devices, Methods, and Systems for Improved Droplet Recovery
18 Jan 24
Devices, methods, and systems for generating droplets are provided.
Brenden Janatpour BROWN, Ivan AKHREMICHEV, Daniel FREITAS, Martin SAUZADE
Filed: 26 Sep 23
Utility
Methods for Spatial Analysis Using Rolling Circle Amplification
18 Jan 24
Provided herein are methods of identifying a location of an analyte in a biological sample using padlock oligonucleotides and rolling circle amplification.
Marco Mignardi
Filed: 21 Oct 21
Utility
Methods for Spatial Analysis Using Targeted Rna Depletion
18 Jan 24
Provided herein are methods for spatial analysis using targeted RNA depletion.
Caroline Julie Gallant, Linda Kvastad
Filed: 15 Aug 23
Utility
Method for Transposase-mediated Spatial Tagging and Analyzing Genomic Dna In a Biological Sample
18 Jan 24
The present disclosure relates to materials and methods for spatially analyzing nucleic acids that have been fragmented with a transposase enzyme, alone or in combination with other types of analytes.
Michael Schnall-Levin, Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Patrik Stahl, Jonas Frisen, Maja Marklund, Enric Llorens Bobadilla
Filed: 6 Jul 23
Utility
Probe-based Analysis of Nucleic Acids and Proteins
18 Jan 24
Provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample.
Katherine Pfeiffer, Andrew Scott Kohlway, Andrew John Hill, Paul Eugene Lund, Jawad N. Abousoud, Sharmila Chatterjee Bhattacharjee, Ryan Stott
Filed: 20 Sep 23
Utility
Methods and compositions for nucleic acid analysis
16 Jan 24
The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.
Xinying Zheng, Serge Saxonov, Michael Schnall-Levin, Kevin Ness, Rajiv Bharadwaj
Filed: 12 Sep 22
Utility
Systems and methods for metabolome analysis
16 Jan 24
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing.
Luigi Jhon Alvarado Martinez
Filed: 19 Jan 23
Utility
Methods, compositions, and systems for spatial analysis of analytes in a biological sample
16 Jan 24
Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.
Hanyoup Kim, David Sukovich, Layla Katiraee, Augusto Manuel Tentori, Lauren Gutgesell, Janine Hensel, Seayar Mohabbat
Filed: 27 Apr 23
Utility
Multiplex Capture of Gene and Protein Expression from a Biological Sample
11 Jan 24
Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.
Jennifer Chew, Joseph Francis Shuga, Patrick Roelli, Denise Cheung, Alexander Hermes, Yifeng Yin, Naishitha Anaparthy, Ryo Hatori, Marlon Stoeckius, Rapolas Spalinskas, Anna-Maria Katsori, Cedric Uytingco, Mesruh Turkekul, David Sukovich, Christina Galonska, Aleksandra Jurek, Octavian Marian Bloju
Filed: 6 Jul 23
Utility
Simultaneous spatio-temporal measurement of gene expression and cellular activity
9 Jan 24
Provided herein are methods for simultaneous spatio-temporal measurement of gene expression and cellular activity.
Cedric Uytingco, Layla Katiraee, Kristen Pham
Filed: 7 Mar 23
Utility
Methods and Systems for Processing Polynucleotides
4 Jan 24
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing.
Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Xinying Zheng, Phillip Belgrader
Filed: 13 Sep 23
Utility
Analysis of Antigen and Antigen Receptor Interactions
4 Jan 24
The present disclosure relates in some aspects to methods of contacting a biological sample (e.g., fresh or frozen tissue sample) with peptide-loaded detection complexes.
Søren Nyboe JAKOBSEN, Malte KÜHNEMUND
Filed: 5 May 23
Utility
Compositions, Systems and Methods for Crispr-based Enzyme Optimization
4 Jan 24
Provided herein are reaction mixtures, compositions, systems, methods, and kits for assessing enzymatic activity.
Michael Gibbons
Filed: 5 May 23
Utility
Probe-based Analysis of Nucleic Acids and Proteins
4 Jan 24
Provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample.
Katherine Pfeiffer, Andrew Scott Kohlway, Andrew John Hill, Paul Eugene Lund, Jawad N. Abousoud, Sharmila Chatterjee Bhattacharjee, Ryan Stott
Filed: 30 Jun 23
Utility
Methods and Systems for Processing Polynucleotides
4 Jan 24
This disclosure provides methods and compositions for sample processing, particularly for sequencing applications.
Christopher Hindson, Michael Schnall-Levin, Andrew Price, Paul Hardenbol, Yuan Li
Filed: 17 Mar 23
Utility
Increasing Efficiency of Spatial Analysis In a Biological Sample
4 Jan 24
Disclosed herein are methods of amplifying an analyte in a biological sample using a bridging oligonucleotide that hybridizes to a captured analyte.
Felice Alessio Bava
Filed: 23 Jun 23
Utility
Click Chemistry-based Dna Photo-ligation for Manufacturing of High-resolution Dna Arrays
4 Jan 24
The present disclosure relates in some aspects to methods and compositions for light-controlled in situ surface patterning of a substrate using a Click chemistry reaction.
Jonathan CHENG, David Michael Patterson
Filed: 28 Jun 23
Utility
Methods and Systems for Cell and Bead Processing
4 Jan 24
The present disclosure provides methods and systems for cell and bead processing or analysis.
Christopher Hindson, Andrew D. Price, Michael Schnall-Levin
Filed: 2 Jun 23
Utility
Magnetic separator for an automated single cell sequencing system
2 Jan 24
A magnetic separator is disclosed.
Pratomo Alimsijah, John Richard Chevillet
Filed: 30 Mar 20
Utility
Nucleic acid library methods
2 Jan 24
Provided herein are methods, compositions, and kits for removing a portion of a sequence in a member of a nucleic acid library.
Caroline Julie Gallant, Marlon Stoeckius, Katherine Pfeiffer
Filed: 7 Feb 23