10 patents
Utility
PI3K-ALPHA Inhibitors and Methods of Use Thereof
2 Nov 23
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure.
Lucian V. DIPIETRO, Kelley C. SHORTSLEEVES, Thomas H. MCLEAN, Alexandre LARIVEE, Fabrizio GIORDANETTO
Filed: 9 Jun 23
Utility
SHP2 Phosphatase Inhibitors and Methods of Use Thereof
27 Jul 23
Alexander M. Taylor, Andre Lescarbbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, W. Patrick Walters, Mark Andrew Murcko, Thomas H. McLean, Hakan Gunaydin, Fabrizio Giordanetto, Eric Therrien
Filed: 15 Dec 22
Utility
FGFR Inhibitors and Methods of Use Thereof
6 Apr 23
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of FGFR enzymes with the compounds and compositions of the disclosure.
Bakary-Barry TOURÉ, Heike SCHOENHERR, Alexander M. TAYLOR, Fabrizio GIORDANETTO, Demetri T. MOUSTAKAS, Thomas H. MCLEAN, Brandi M. HUDSON, Mary M. MADER, Pelin AYAZ, Dina A. SHARON, Ravi KURUKULASURIYA, Alessandro BOEZIO
Filed: 12 May 20
Utility
SHP2 Phosphatase Inhibitors and Methods of Use Thereof
27 Oct 22
Alexander M. Taylor, André Lescarbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, W. Patrick Walters, Mark Andrew Murcko, Thomas H. McLean, Hakan Gunaydin, Fabrizio Giordanetto, Eric Therrien
Filed: 17 Nov 20
Utility
SHP2 Phosphatase Inhibitors and Methods of Use Thereof
6 Oct 22
Alexander M. Taylor, André Lescarbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, W. Patrick Walters, Mark Andrew Murcko, Thomas H. McLean, Hakan Gunaydin, Fabrizio Giordanetto, Eric Therrien
Filed: 21 Mar 19
Utility
FGFR Inhibitors and Methods of Making and Using the Same
23 Jun 22
The disclosure is in part directed to crystalline forms of N-(4-(4-amino-5-(3-fluoro-4-(4-methylpyrimidin-2-yl)oxy)phenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)methacrylamide, its salts, its cocrystals, and variants thereof.
André LESCARBEAU, Jethro BEAMISH-COOK, Zoe PRENTICE, Thomas KENDALL, Aaron DUMAS, Elisabeth ISAAK, Piera TRINCHERA, Oleksandr ZHURAKOVSKYI, Osama SULEIMAN
Filed: 18 Nov 21
Utility
SHP2 Phosphatase Inhibitors and Methods of Making and Using the Same
25 Mar 21
The disclosure is in part directed to crystalline forms of (R)-1′-(3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4′-piperidin]-3-amine, its salt, and variants thereof.
Alexander M. Taylor, André Lescarbeau, Jing Wang, Yanyan Zhang, Gaodeng Lian
Filed: 23 Sep 20
Utility
PYRAZOLO[3,4-B]PYRAZINE SHP2 Phosphatase Inhibitors and Methods of Use Thereof
11 Mar 21
Alexander M. Taylor, Fabrizio Giordanetto, Jack Benjamin Greisman, Paul Maragakis, Heike Schoenherr
Filed: 21 Mar 19
Utility
SHP2 Phosphatase Inhibitors and Methods of Use Thereof
16 Dec 20
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure.
W. Patrick Walters, André Lescarbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, Alexander M. Taylor, Levi Charles Thomas Pierce, Mark Andrew Murcko, Fabrizio Giordanetto, Jack Benjamin Greisman, Paul Maragakis, Sathesh Bhat, Kyle Konze, Markus Kristofer Dahlgren, Eric Therrien
Filed: 20 Feb 19
Utility
PYRAZOLO[3,4-B]PYRAZINE Derivatives As SHP2 Phosphatase Inhibitors
12 Aug 20
Alexander M. Taylor, W. Patrick Walters, Mark Andrew Murcko, Fabrizio Giordanetto, Eric Therrien, Sathesh Bhat, Markus Kristofer Dahlgren
Filed: 27 Sep 18
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