124 patents
Page 2 of 7
Utility
Optical and Electrical Secondary Path Rejection
10 Aug 23
Described herein are techniques to reduce or remove the impact of secondary path photons and/or charge carriers on storage bins of an integrated device to improve noise performance, and thus, sample analysis.
Dajiang Yang, Farshid Ghasemi, Keith G. Fife, Todd Rearick, Ali Kabiri, Gerard Schmidt, Eric A.G. Webster
Filed: 11 Apr 23
Utility
Integrated photodetector with direct binning pixel
8 Aug 23
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 2 Aug 21
Utility
Integrated device for temporal binning of received photons
8 Aug 23
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 23 Nov 21
Utility
Integrated sensor for multi-dimensional signal analysis
8 Aug 23
Some aspects relate to an integrated circuit, comprising at least one photodetection region configured to generate charge carriers responsive to incident photons emitted from a sample, at least one charge storage region configured to receive the charge carriers from the photodetection region, and at least one controller configured to obtain information about the incident photons, the information comprising at least one member selected from the group comprising pulse duration and interpulse duration and at least one member selected from the group comprising wavelength information, luminescence lifetime information, and intensity information.
Gerard Schmid, Dajiang Yang, Eric A. G. Webster, Xin Wang, Todd Rearick, Changhoon Choi, Ali Kabiri, Kyle Preston, Brian Reed
Filed: 2 Mar 21
Utility
Integrated circuit with sequentially-coupled charge storage and associated techniques comprising a photodetection region and charge storage regions to induce an intrinsic electric field
1 Aug 23
Described herein are techniques that improve the collection and readout of charge carriers in an integrated circuit.
Eric A. G. Webster, Todd Rearick, Thomas Raymond Thurston
Filed: 21 Oct 21
Utility
Surface modification in the vapor phase
1 Aug 23
Aspects of the application provide methods of producing substrates having modified surfaces.
Guojun Chen, Jeremy Lackey
Filed: 9 Oct 20
Utility
Integrated Sensor
13 Jul 23
Aspects of the technology described herein relate to improved semiconductor-based image sensor designs.
Gerard Schmid, Todd Rearick, Brian Reed
Filed: 11 Jan 23
Utility
Labeled Binding Reagents and Methods of Use Thereof
13 Jul 23
Aspects of the disclosure provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same.
Brian Reed, Todd Rearick, Gerard Schmid
Filed: 11 Jan 23
Utility
Techniques for Sequencing
13 Jul 23
Techniques for multi-dimensional signal analysis are described herein.
Brian Reed, Todd Rearick, Gerard Schmid, Haidong Huang
Filed: 11 Jan 23
Utility
Compositions and Methods for Polypeptide Analysis
6 Jul 23
Aspects of the application relate to methods and systems for obtaining information regarding multiple amino acids in a polypeptide based on binding interactions between the polypeptide and one or more amino acid recognizers.
Brian Reed, Manjula Pandey, David Kamber, Kenneth Skinner
Filed: 22 Dec 22
Utility
Optical nanostructure rejecter for an integrated device and related methods
4 Jul 23
Apparatus and methods relating to photonic bandgap optical nanostructures are described.
Ali Kabiri, Bing Shen, James Beach, Kyle Preston, Gerard Schmid
Filed: 18 Jun 20
Utility
Machine Learning Enabled Pulse and Base Calling for Sequencing Devices
29 Jun 23
A method includes obtaining, from one or more sequencing devices, raw data detected from luminescent labels associated with nucleotides during nucleotide incorporation events; and processing the raw data to perform a comparison of base calls produced by a learning enabled, automatic base calling module of the one or more sequencing devices with actual values associated with the raw data, wherein the base calls identify one or more individual nucleotides from the raw data.
Jonathan M. Rothberg, Michael Meyer, Umut Eser
Filed: 15 Dec 22
Utility
High intensity labeled reactant compositions and methods for sequencing
23 May 23
Compositions useful for the detection of single molecules in a sample are provided.
Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
Filed: 24 Jul 18
Utility
Integrated Sensor with Reduced Skew
18 May 23
Aspects of the present disclosure relate to techniques for reducing skew in an integrated device, such as a CMOS imaging device.
Eric A.G. Webster, Dajiang Yang, Xin Wang, Zhaoyu He, Changhoon Choi, Peter J. Lim, Todd Rearick
Filed: 4 Jan 23
Utility
Optical Sources for Fluorescent Lifetime Analysis
18 May 23
Compact optical sources and methods for producing short and ultrashort optical pulses are described.
Jonathan M. Rothberg, Jason W. Sickler, Lawrence C. West, Faisal R. Ahmad, Brendan Huang, Paul E. Glenn, Jonathan C. Schultz, Jose Camara
Filed: 6 Jan 23
Utility
Integrated Photodetector with Charge Storage Bin of Varied Detection Time
4 May 23
Thomas Raymond Thurston, Benjamin Cipriany, Joseph D. Clark, Todd Rearick, Keith G. Fife
Filed: 14 Jun 22
Utility
Light Coupling Device
13 Apr 23
An integrated device, comprising a substrate having a first surface; and at least one pixel formed on or in the substrate.
Gerard Schmid, Ali Kabiri, Seled Ali Safiabadi Tali
Filed: 7 Oct 22
Utility
High intensity labeled reactant compositions and methods for sequencing
28 Mar 23
Compositions useful for the detection of single molecules in a sample are provided.
Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
Filed: 23 Jan 20
Utility
Polymerizing Enzymes for Sequencing Reactions
23 Feb 23
Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes.
Brian Reed, Mohammad Wadud Bhuiya, Manjula Pandey, Jeremy Lackey, Jonathan M. Rothberg, Thomas Christian
Filed: 9 Mar 22
Utility
Systems and Methods for Unifying Statistical Models for Different Data Modalities
9 Feb 23
Techniques for performing a prediction task using a multi-modal statistical model configured to receive input data from multiple modalities including input data from a first modality and input data from a second modality different from the first modality.
Jonathan M. Rothberg, Umut Eser, Michael Meyer
Filed: 17 Oct 22