41 patents
Utility
Systems and methods for unifying statistical models for different data modalities
16 Jan 24
Jonathan M. Rothberg, Umut Eser, Michael Meyer
Filed: 17 Oct 22
Utility
Integrated sensor for lifetime characterization
9 Jan 24
Aspects of the technology described herein relate to improved semiconductor-based image sensor designs.
Eric A. G. Webster, Changhoon Choi, Dajiang Yang, Xin Wang, Todd Rearick, Kyle Preston, Ali Kabiri, Gerard Schmid
Filed: 14 Jan 21
Utility
Compact mode-locked laser module
19 Dec 23
Apparatus and methods for producing ultrashort optical pulses are described.
Jonathan M. Rothberg, Jason W. Sickler, Lawrence C. West, Faisal R. Ahmad, Paul E. Glenn, Jack Jewell, John Glenn, Jose Camara, Jeremy Christopher Jordan, Todd Rearick, Farshid Ghasemi, Jonathan C. Schultz, Keith G. Fife, Benjamin Cipriany
Filed: 16 Mar 22
Utility
Data acquisition control for advanced analytic instruments having pulsed optical sources
7 Nov 23
Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described.
Jonathan M. Rothberg, Benjamin Cipriany, Faisal R. Ahmad, Joseph D. Clark, Daniel B. Frier, Michael Ferrigno, Mel Davey, Tom Thurston, Brett J. Gyarfas, Todd Rearick, Jeremy Christopher Jordan
Filed: 14 Jun 19
Utility
Optical and electrical secondary path rejection
31 Oct 23
Described herein are techniques to reduce or remove the impact of secondary path photons and/or charge carriers on storage bins of an integrated device to improve noise performance, and thus, sample analysis.
Dajiang Yang, Farshid Ghasemi, Keith G. Fife, Todd Rearick, Ali Kabiri, Gerard Schmid, Eric A. G. Webster
Filed: 26 Jun 20
Utility
Enrichment of nucleic acid targets
24 Oct 23
Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
Andrea Marziali, Milenko Despotovic, Joel Pel
Filed: 9 Apr 21
Utility
Optical waveguides and couplers for delivering light to an array of photonic elements
3 Oct 23
Optical waveguides and couplers for delivering light to an array of photonic elements in a photonic integrated device.
Kyle Preston, Bing Shen, Ali Kabiri, Gerard Schmid
Filed: 3 Jan 20
Utility
Sliced grating coupler with increased beam alignment sensitivity
5 Sep 23
Apparatus and methods relating to coupling radiation from an incident beam into a plurality of waveguides with a grating coupler are described.
Gerard Schmid, Kyle Preston, Shannon Stewman
Filed: 29 Apr 20
Utility
Integrated photodetector with direct binning pixel
8 Aug 23
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 2 Aug 21
Utility
Integrated device for temporal binning of received photons
8 Aug 23
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 23 Nov 21
Utility
Integrated sensor for multi-dimensional signal analysis
8 Aug 23
Some aspects relate to an integrated circuit, comprising at least one photodetection region configured to generate charge carriers responsive to incident photons emitted from a sample, at least one charge storage region configured to receive the charge carriers from the photodetection region, and at least one controller configured to obtain information about the incident photons, the information comprising at least one member selected from the group comprising pulse duration and interpulse duration and at least one member selected from the group comprising wavelength information, luminescence lifetime information, and intensity information.
Gerard Schmid, Dajiang Yang, Eric A. G. Webster, Xin Wang, Todd Rearick, Changhoon Choi, Ali Kabiri, Kyle Preston, Brian Reed
Filed: 2 Mar 21
Utility
Integrated circuit with sequentially-coupled charge storage and associated techniques comprising a photodetection region and charge storage regions to induce an intrinsic electric field
1 Aug 23
Described herein are techniques that improve the collection and readout of charge carriers in an integrated circuit.
Eric A. G. Webster, Todd Rearick, Thomas Raymond Thurston
Filed: 21 Oct 21
Utility
Surface modification in the vapor phase
1 Aug 23
Aspects of the application provide methods of producing substrates having modified surfaces.
Guojun Chen, Jeremy Lackey
Filed: 9 Oct 20
Utility
Optical nanostructure rejecter for an integrated device and related methods
4 Jul 23
Apparatus and methods relating to photonic bandgap optical nanostructures are described.
Ali Kabiri, Bing Shen, James Beach, Kyle Preston, Gerard Schmid
Filed: 18 Jun 20
Utility
High intensity labeled reactant compositions and methods for sequencing
23 May 23
Compositions useful for the detection of single molecules in a sample are provided.
Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
Filed: 24 Jul 18
Utility
High intensity labeled reactant compositions and methods for sequencing
28 Mar 23
Compositions useful for the detection of single molecules in a sample are provided.
Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
Filed: 23 Jan 20
Utility
Integrated sensor with reduced skew
7 Feb 23
Aspects of the present disclosure relate to techniques for reducing skew in an integrated device, such as a CMOS imaging device.
Eric A. G. Webster, Dajiang Yang, Xin Wang, Zhaoyu He, Changhoon Choi, Peter J. Lim, Todd Rearick
Filed: 7 Apr 21
Utility
Optical sources for fluorescent lifetime analysis
31 Jan 23
Compact optical sources and methods for producing short and ultrashort optical pulses are described.
Jonathan M. Rothberg, Jason W. Sickler, Lawrence C. West, Faisal R. Ahmad, Brendan Huang, Paul E. Glenn, Jonathan C. Schultz, Jose Camara
Filed: 23 Jan 20
Utility
Machine learning enabled pulse and base calling for sequencing devices
27 Dec 22
A method includes obtaining, from one or more sequencing devices, raw data detected from luminescent labels associated with nucleotides during nucleotide incorporation events; and processing the raw data to perform a comparison of base calls produced by a learning enabled, automatic base calling module of the one or more sequencing devices with actual values associated with the raw data, wherein the base calls identify one or more individual nucleotides from the raw data.
Jonathan M. Rothberg, Michael Meyer, Umut Eser
Filed: 25 Jan 19
Utility
Systems and methods for unifying statistical models for different data modalities
8 Nov 22
Techniques for performing a prediction task using a multi-modal statistical model configured to receive input data from multiple modalities including input data from a first modality and input data from a second modality different from the first modality.
Jonathan M. Rothberg, Umut Eser, Michael Meyer
Filed: 8 Mar 21