Maravai LifeSciences (MRVI) USPTO patents

Utility

Compositions and Methods for Synthesizing 5'-CAPPED Rnas

15 Sep 22

Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.

Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN

Filed: 26 May 22

Utility

Compositions and methods for synthesizing 5′-capped RNAs

16 Aug 22

Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.

Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin

Filed: 2 Aug 21

Utility

Immunofluorescence Assays

24 Feb 22

Provided herein are immunofluorescence assays that do not use an intensely colored lipophilic dye, and that result in a significant reduction of fluorescence due to aldehyde fixation, collagen, elastin, and/or red blood cells.

Timothy B. KARPISHIN, Pamela JAMES, Erika LEONARD

Filed: 5 Apr 21

Utility

Compositions and Methods for Synthesizing 5'-CAPPED Rnas

2 Dec 21

Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.

Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN

Filed: 2 Aug 21

Utility

Compositions and Methods for Synthesizing 5'-CAPPED Rnas

26 Aug 21

Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7 Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.

Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN

Filed: 6 Nov 20

Utility

Stock Solution of Retrovirus Like Particles with Method and Kit

27 May 21

The present invention relates to a stock solution (RLP Stock Solution) of mammalian cell-endogenous retrovirus like particles (RLP), a method of preparing a RLP stock solution, a kit containing a RLP stock solution, and a method of quantifying the amount of RLP removed from a solution.

David Cetlin, Arun Dhar

Filed: 4 Feb 21

Utility

Immunofluorescence assays

6 Apr 21

Provided herein are immunofluorescence assays that do not use an intensely colored lipophilic dye, and that result in a significant reduction of fluorescence due to aldehyde fixation, collagen, elastin, and/or red blood cells.

Timothy B. Karpishin, Pamela James, Erika Leonard

Filed: 3 May 18