15 patents
Utility
Methods for detecting biallelic loss of function in next-generation sequencing genomic data
28 Nov 23
A genomic data analyzer maybe configured to detect and characterize biallelic genomic alterations for at least one gene in next generation sequencing variant calling information for patient tumor samples characterized by different purity ratios of somatic genomic material.
Christian Pozzorini, Zhenyu Xu
Filed: 24 Jul 18
Utility
Methods and Systems for Detecting Tumor Mutational Burden
6 Jul 23
A computer-implemented method may obtain variant calling data for the tumor sample.
Jonathan Bieler, Yvan Wenger, Christian Pozzorinni, Zhenyu Xu
Filed: 30 Dec 22
Utility
Capture Probes and Uses Thereof
1 Dec 22
The present invention is directed to the probes for detecting known and unknown fusion genes, related methods of detection of fusion genes, uses and kits related thereto.
Gabriela ECCO, Xiaobin XING, Adrian WILLIG, Zhenyu XU
Filed: 24 Sep 21
Utility
Methods for Dna Library Generation to Facilitate the Detection and Reporting of Low Frequency Variants
17 Nov 22
Methods are disclosed for adding adapters to fragmented nucleic acids for next generation sequencing, including providing numerical codes based on variable adapter molecular barcode lengths on both sides of the fragmented nucleic acids and identifying reads from the same fragment based on both barcodes.
Morgane MACHERET, Christian POZZORINI, Adrian WILLIG, Jonathan BIELER, Zhenyu XU
Filed: 21 Sep 20
Utility
Methods to Compress, Encrypt and Retrieve Genomic Alignment Data
27 Oct 22
A genomic data decoder may jointly compress and encrypt genomic data alignment information while preserving the privacy of sensitive genomic data elements at retrieval stage.
Adam MOLYNEAUX, Erman AYDAY, Jean-Pierre HUBAUX, Jesus GARCIA, Zhicong HUANG, Huang LIN
Filed: 8 Jul 22
Utility
Methods for Identifying Chromosomal Spatial Instability Such As Homologous Repair Deficiency In Low Coverage Next- Generation Sequencing Data
29 Sep 22
A genomic data analyzer may be configured to detect and characterize, with a machine learning model such as a trained convolutional neural network, the presence of a genomic instability in a tumor sample.
Christian Pozzorini, Gregoire Andre, Tommaso Coletta, Zhenyu Xu
Filed: 7 Mar 22
Utility
Methods to compress, encrypt and retrieve genomic alignment data
19 Jul 22
A genomic data decoder may jointly compress and encrypt genomic data alignment information while preserving the privacy of sensitive genomic data elements at retrieval stage.
Adam Molyneaux, Erman Ayday, Jean-Pierre Hubaux, Jesus Garcia, Zhicong Huang, Huang Lin
Filed: 8 Mar 17
Utility
Methods for Detecting and Characterizing Microsatellite Instability with High Throughput Sequencing
14 Jul 22
The characterization, classification and reporting of MSI status of patient genomic samples may be provided by high throughput genomic analysis of a set of microsatellite marker loci.
Lin SONG, Xiaboin XING, Zhenyu XU
Filed: 5 Feb 21
Utility
Methods for Detecting Copy-number Variations In Next-generation Sequencing
28 Apr 22
Copy Number Variants (CNV) detection methods may integrate CNV detection into workflow for next generation sequencer (NGS) data processing, in parallel with SNP and INDEL variant calling.
Dmitri IVANOV, Zhenyu XU
Filed: 20 Oct 21
Utility
Methods for Detecting Copy-number Variations In Next-generation Sequencing
31 Mar 22
Copy Number Variants (CNV) detection methods described herein may efficiently integrate CNV detection into the workflow for a next generation sequencer (NGS) data processing, in parallel with SNP and INDEL variant calling.
Dmitri IVANOV, Zhenyu XU
Filed: 20 Oct 21
Utility
Methods for Identifying Chromosomal Spatial Instability Such As Homologous Repair Deficiency In Low Coverage Next- Generation Sequencing Data
17 Mar 22
A genomic data analyzer may be configured to detect and characterize, with a machine learning model such as a trained convolutional neural network, the presence of a genomic instability in a tumor sample.
Christian Pozzorini, Gregoire Andre, Tommaso Coletta, Zhenyu Xu
Filed: 23 Nov 21
Utility
Method to Provide Personalized Medical Data
3 Feb 22
A method to provide personalized data of a patient includes obtaining at least one first personal data for a non-modifiable risk factor, obtaining at least one second personal data for a modifiable risk factor, and normalizing the first and second data using a lookup table, said normalized data representing an increase or decrease versus a neutral value.
David COX, Gilbert PERRIN
Filed: 28 Sep 19
Utility
Methods for Identifying Chromosomal Spatial Instability Such As Homologous Repair Deficiency In Low Coverage Next-generation Sequencing Data
27 Jan 22
A genomic data analyzer may be configured to detect and characterize, with a machine learning model such as a trained convolutional neural network, the presence of a genomic instability in a tumor sample.
Christian Pozzorini, Gregoire Andre, Tommaso Coletta, Zhenyu Xu
Filed: 27 Jul 21
Utility
Methods for Detecting Biallelic Loss of Function In Next-generation Sequencing Genomic Data
25 Nov 21
A genomic data analyzer maybe configured to detect and characterize, with a variant analysis module, biallelic genomic alterations for at least one gene in next generation sequencing variant calling information for patient tumor samples characterized by different purity ratios of somatic genomic material.
Christian POZZORINI, Zhenyu XU
Filed: 24 Jul 18
Utility
Methods for Asymmetric Dna Library Generation and Optionally Integrated Duplex Sequencing
14 Oct 21
Methods and products are disclosed for asymmetrically adapting fragmented nucleic acids for next generation sequencing, including providing strand identifier sequences and index sequences to identify the source strand and sample, respectively, of the fragmented nucleic acids.
Alisa ALEKSEENKO, Vicente Jose PELECHANO GARCIA
Filed: 28 Aug 19
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