11 patents
Utility
Methods for Controlled Activation And/or Expansion of Genetically Engineered Cells Using Polyethylene Glycol (Peg) Receptors
30 Nov 23
Provided are genetically engineered induced pluripotent stem cells (iPSCs) and derivative cells thereof expressing a polyethylene glycol (PEG) receptors and methods of using the same.
Hyam Levitsky, Andreia Costa, John Wheeler, Melissa Chiasson, Eric Eymard, Rupesh Amin
Filed: 20 Apr 23
Utility
Artificial Cell Death Polypeptide For Chimeric Antigen Receptor And Uses Thereof
30 Nov 23
Provided are polynucleotides encoding inactivated cell surface receptors.
Michael Naso, Jill Carton, John Wheeler, Luis Borges
Filed: 30 Mar 23
Utility
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
30 May 23
Provided are polynucleotides encoding inactivated cell surface receptors.
Michael Naso, Jill Carton, John Wheeler, Luis Borges
Filed: 1 Dec 21
Utility
Gene Transfer Vectors and Methods of Engineering Cells
20 Oct 22
The present disclosure provides compositions and methods for use in genome engineering of induced pluripotent stem cells (iPSCs).
Michael Francis NASO, Buddha GURUNG, Jill Marinari CARTON, John WHEELER, Luis Ghira BORGES
Filed: 6 Apr 22
Utility
Combined Artificial Cell Death/Reporter System Polypeptide for Chimeric Antigen Receptor Cell and Uses Thereof
20 Oct 22
A combined artificial cell death/reporter system polypeptide containing a herpes simplex virus thymidine kinase (HSV-tk) fused to a prostate-specific membrane antigen (PSMA) polypeptide via a linker is described.
Michael Francis Naso, Luis Borges, Buddha Gurung
Filed: 4 Apr 22
Utility
Compositions and Methods for Generating Gamma-Delta T Cells from Induced Pluripotent Stem Cells
20 Oct 22
Provided are methods for generating γδ T cells from induced pluripotent stem cells.
Mark Wallet, Toshinobu Nishimura, Mark Mendonca, Andriana Lebid, Brenda Salantes, Katherine Santostefano, Michael Francis Naso, Buddha Gurung, Zengrong Zhu, Barry Morse, Luis Borges, Christina Del Casale, Marilda Beqiri, Lucas Thompson
Filed: 4 Apr 22
Utility
Compositions and Methods for Generating Alpha-Beta T Cells from Induced Pluripotent Stem Cells
20 Oct 22
Provided are method for generating αβ T cells from induced pluripotent stem cells.
Mark Wallet, Katherine Santostefano, Brenda Salantes, Mark Mendonca, Toshinobu Nishimura, Michael Francis Naso, Buddha Gurung, Zengrong Zhu, Barry Morse, Luis Borges, Jill Marinari Carton
Filed: 4 Apr 22
Utility
Chimeric Antigen Receptor System with Adaptable Receptor Specificity
23 Jun 22
The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have adaptable receptor specificity (arCARs).
Jill Marinari CARTON, Michael Francis NASO, Luis Ghira BORGES, John WHEELER, Andrew DEVANEY
Filed: 17 Dec 21
Utility
Genetically Engineered Cells and Uses Thereof
23 Jun 22
Provided are genetically engineered induced pluripotent stem cells (iPSCs) and derivative cells thereof expressing a chimeric antigen receptor (CAR) and methods of using the same.
Michael Naso, Jill Carton, Mark Wallet, Barry Morse, Luis Borges, Buddha Gurung, Hillary Quinn, Liam Campion, Heidi Jessup, Kenneth Brasel, Lucas Thompson
Filed: 1 Dec 21
Utility
Genetically Engineered Cells and Uses Thereof
16 Jun 22
Provided are genetically engineered induced pluripotent stem cells (iPSCs) and derivative cells thereof expressing a chimeric antigen receptor (CAR) and methods of using the same.
Michael Naso, Jill Carton, Mark Wallet, Barry Morse, Luis Borges, Hillary Quinn, Liam Campion, Buddha Gurung, Heidi Jessup, Kenneth Brasel, Lucas Thompson
Filed: 1 Dec 21
Utility
Artificial Cell Death Polypeptide For Chimeric Antigen Receptor And Uses Thereof
9 Jun 22
Provided are polynucleotides encoding inactivated cell surface receptors.
Michael Naso, Jill Carton, John Wheeler, Luis Borges
Filed: 1 Dec 21
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