5 patents
Utility
Fusion Proteins Comprising a Ligand-receptor Pair and a Biologically Functional Protein
19 Oct 23
The present disclosure provides fusion proteins with a multifunctional biologic design for programmed target engagement.
Surjit Bhimarao Dixit, Gesa Volkers, Florian Heinkel, Eric ESCOBAR-CABRERA, Thomas Spreter Von Kreudenstein, Anna Von Rossum
Filed: 20 Jul 21
Utility
Bispecific Antigen Binding Constructs Targeting HER2
20 Apr 23
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2.
Nina E. Weisser, Gordon Yiu Kon Ng, Grant Raymond Wickman, Surjit Bhimarao Dixit, Eric Escobar-Cabrera, Mario Sanches
Filed: 25 Apr 22
Utility
Masked IL12 Fusion Proteins and Methods of Use Thereof
20 Apr 23
The present disclosure relates to masked IL12 fusion proteins, compositions comprising the same and methods of using the compositions for the treatment of a variety of diseases including cancer.
Ryan Blackler, Gesa Volkers, David Douda, Thomas Spreter Von Kreudenstein, Genevieve Desjardins, Nicole Afacan
Filed: 23 Mar 21
Utility
Antibody Constructs Binding 4-1BB and Tumor-associated Antigens and Uses Thereof
16 Feb 23
Described herein are antibody constructs comprising a 41-1BB binding domain and an antigen-binding domain that binds to a tumor-associated antigen (TAA), wherein the 4-1BB-binding domain and the TAA antigen-binding domain are linked directly or indirectly to a scaffold.
Daniel T. PATTON, David M. MILLS, Thomas SPRETER VON KREUDENSTEIN, Gesa VOLKERS, Dunja UROSEV, Lee FREIBURGER, Zhuang DUAN, Elizabeth HALVORSEN, Harsh PRATAP, Brandon CLAVETTE, Anna VON ROSSUM, Duncan BROWMAN, Peter Wing Yiu CHAN, Danny CHUI, Robert William GENE, Sylwia JANCOWSKI, Sukhbir Singh KANG, Patricia ZWIERZCHOWSKI
Filed: 9 Apr 21
Utility
Sulfonamide-containing linkage systems for drug conjugates
24 Jan 23
Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates.
Geoffrey C. Winters, Alexander L. Mandel, Elyse Marie Josée Bourque, James R. Rich, Tom Han Hsiao Hsieh
Filed: 29 Dec 14
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