77 patents
Utility
Assays for detecting modified compounds
16 Jan 24
Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified.
Elazar Rabbani, Jannis G. Stavrianopoulos, Joshua Rabbani, Praveen Pande
Filed: 14 Oct 21
Utility
Sphingosine pathway modulating compounds for the treatment of cancers
9 Jan 24
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani, James J. Donegan
Filed: 19 Nov 20
Utility
Compositions for Preparing Regulatory T-Cell Compositions for the Treatment of Autoimmune Disease
16 Nov 23
The invention provides cell culture compositions for regulatory T-cells that include particular synthetic peptides.
Robert NUSSENBLATT, Baoying LIU, Lai WEI, Elazar RABBANI, James J. DONEGAN
Filed: 26 Jul 23
Utility
Reduced background immunoassay plates
5 Sep 23
The invention provides reduced background substrates, such as multi-well plates, for use in enzyme-linked immunosorbent assays (ELISAs) and other ligand-binding assays, and methods for making and using the same.
Elazar Rabbani
Filed: 21 Jun 21
Utility
Sphingosine pathway modulating compounds for the treatment of coronavirus infection
15 Aug 23
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 10 Mar 21
Utility
Self-immolative probes for enzyme activity detection
30 May 23
Irina Lebedeva, Wayne Forrest Patton, Maciej Szczepanik, Yuejun Xiang, Praveen Pande
Filed: 28 May 20
Utility
Sphingosine Pathway Modulating Compounds For The Treatment Of Coronavirus Infection
25 May 23
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 11 Jan 23
Utility
Antibodies specific for sulfation sites of Wnt pathway proteins
2 May 23
Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a.
Joshua Rabbani, James J. Donegan
Filed: 22 Dec 20
Utility
Sphingosine pathway modulating compounds for the treatment of coronavirus infection
17 Jan 23
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 10 Mar 21
Utility
Use of Organic Cationic Compounds to Accelerate Nucleic Acid Hybridization, Synthesis, and Amplification
5 Jan 23
The invention provides methods for accelerated synthesis of nucleic acids, and related compositions which involve the use of organic amines in the nucleic acid synthesis reaction mixture.
Elazar Rabbani, Jack Coleman
Filed: 15 Dec 21
Utility
Assays for Detecting Modified Compounds
3 Feb 22
Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified.
Elazar Rabbani, Jannis G. Stavrianopoulos, Joshua Rabbani, Praveen Pande
Filed: 14 Oct 21
Utility
Immunomodulatory Pharmaceutical Compositions Including a Synthetic Peptide and Transforming Growth Factor Beta
27 Jan 22
The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and one or more immune tolerance enhancers.
Robert Nussenblatt, Baoying Liu, Lai Wei, Elazar Rabbani, James J. Donegan
Filed: 12 Oct 21
Utility
Pharmaceutical Compositions and Methods Targeting WNT Pathway Proteins
27 Jan 22
Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213.
Joshua Rabbani, Xiaofeng Li, James J. Donegan
Filed: 5 Oct 21
Utility
Fluorescence Quencher Polymer Conjugates and Uses Thereof
27 Jan 22
The invention provides chemical conjugates comprising a plurality of fluorescence quenching moieties conjugated to polymer and the use of such conjugates to quench the emission of fluorescence from emitters including macromolecular fluorescent emitters such as phycoerythrin.
Elazar Rabbani, Jack Coleman
Filed: 30 Jun 21
Utility
Assays for detecting modified compounds
23 Nov 21
Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified.
Elazar Rabbani, Jannis G. Stavrianopoulos, Joshua Rabbani, Praveen Pande
Filed: 19 Dec 18
Utility
Immunomodulatory pharmaceutical compositions including a synthetic peptide and transforming growth factor beta
16 Nov 21
The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and transforming growth factor beta, (TGF-β).
Robert Nussenblatt, Baoying Liu, Lai Wei, Elazar Rabbani, James J. Donegan
Filed: 2 Jun 20
Utility
Methods for treating bone loss using sclerostin peptides
9 Nov 21
Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213.
Joshua Rabbani, Xiaofeng Li, James J. Donegan
Filed: 29 Apr 19
Utility
Multisignal reagents for labeling analytes
2 Nov 21
Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer.
Jack Coleman, Maciej Szczepanik, Richard Jin
Filed: 9 Mar 20
Utility
Comprehensive and Comparative Flow Cytometry-based Methods for Identifying the State of a Biological System
30 Sep 21
The invention provides comprehensive and comparative flow cytometry-based methods for characterizing the state of a biological system by determining cell phenotypes and associated gene expression profiles.
Elazar Rabbani, James J. Donegan, Andrew Stewart L'Huillier
Filed: 4 May 21
Utility
Hydroxycholesterol Immunoassay
30 Sep 21
Provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol.
Michael C. Mullenix, ROBERT ELLIOT ZIPKIN, JEFFREY KROLL ADAMS, WAYNE FORREST PATTON, JAMES J. DONEGAN
Filed: 14 Apr 21