319 patents
Utility
Methods and Devices for Measuring Duplex Unwinding or Strand Exchange Efficiency
18 Jan 24
Provided herein are quantitative assays to evaluate duplex unwinding efficiency or strand exchange efficiency during isothermal amplification.
Yanhong Tong, Yali Sun, Thomas Perroud
Filed: 12 Jul 22
Utility
Method for detecting an error state when aspirating a liquid
9 Jan 24
A method for detecting an error state when aspirating a liquid to identify whether a pre-determined volume of liquid was aspirated.
Danny Farell, Anna Katharina Laarmann
Filed: 18 Jun 22
Utility
Electrophoresis-mediated Characterization of Dna Content of Adeno-associated Virus Capsids
7 Dec 23
According to aspects of methods of characterizing a population of particles putatively containing recombinant nucleic acids in a fluid sample of the present disclosure, includes extracting nucleic acids from the particles, labeling the extracted recombinant nucleic acids, separating the labeled nucleic acids by size, and comparing the separated labeled nucleic acids with a standard to determine one or more of: 1) a ratio of full viral particles to empty viral particles in the fluid sample, 2) a ratio of full viral particles or empty viral particles to partially full viral particles, and 3) a ratio of viral particles containing an intact recombinant genome to viral particles containing an incomplete recombinant genome, thereby characterizing the population of particles in the fluid sample.
James White, Brendan Curran, Lloyd Bwanali, James Atwood, Shreyas Shah, Dipti Mehta, Menel Ben Frej
Filed: 31 May 23
Utility
Autoantibodies to Septin-7 and diagnosis of neurological disease
5 Dec 23
A method for diagnosing a disease can include detecting, in a sample from a patient, an autoantibody binding to Septin-7.
Ramona Miske, Madeleine Scharf, Lars Komorowski, Yvonne Denno, Stefanie Hahn, Christiane Radzimski, Mandy Unger, Andrew McKeon, Sean Pittock, Thomas Kryzer, Vanda Lennon, Josephe Honorat
Filed: 8 Dec 20
Utility
Immunoassay for the diagnosis of viral infections
28 Nov 23
A recombinant polypeptide can be used in the diagnosis of the presence of a Zika virus in a patient.
Katja Steinhagen, Andrea Deerberg, Erik Lattwein, Christiane Radzimski, Jana Böthfür
Filed: 1 Oct 20
Utility
Compositions and Methods Relating to Loop Mediated Isothermal Amplification (Lamp)
16 Nov 23
Methods for detection of a target nucleic acid in a sample are provided according to aspects of the present disclosure which include: providing a reaction mixture comprising a LAMP assay primer set specific for the target nucleic acid, magnesium, dNTPs, a reaction buffer, a DNA polymerase, and a sample to be tested for presence of the target nucleic acid, wherein the LAMP assay primer set comprises a forward inner primer (FIP), a backward inner primer (BIP), a forward outer primer (F3) and a backward outer primer (B3), wherein the FIP and BIP are present in a non-equal ratio such that molar concentration of BIP is highly skewed relative to molar concentration of FIP.
Eva May Ng, Matthew Hooper, Nicolas M. Kosa, Erik Breitenfeldt
Filed: 16 May 22
Utility
Pipetting Apparatus and Methods
16 Nov 23
An automated pipetting system includes a pipettor.
Thomas Perroud, Thomas Rawlins, Hans-Juergen Tiedtke, Kai Hassler
Filed: 11 May 22
Utility
Pipetting Apparatus and Methods
16 Nov 23
An automated pipetting system includes a pipettor.
Thomas Perroud, Thomas Rawlins, Hans-Juergen Tiedtke, Kai Hassler
Filed: 26 May 22
Utility
Pressure-tight storage vessel containing a liquid
14 Nov 23
A pressure-tight storage vessel contains a liquid, has an elongated main body rotationally symmetrical with respect to an axis of symmetry, and forms, at least partially, a rotationally symmetrical hollow space in which the liquid is substantially received, wherein the main body is terminated at its bottom side by a base.
Bianca Huth, Alexander Kowtun, Lars Koschinat, Frank Mollenhauer, Winfried Stoecker
Filed: 18 Dec 19
Utility
Devices, systems and methods for loading samples
14 Nov 23
Certain embodiments described herein are directed to devices and system that can be used to fill a sample cell.
Nigel Thornton Hopley White, Steven Edward Liebold, Gary Vincent Millard
Filed: 30 Sep 20
Utility
Methods, Compositions, and Kits for Inhibiting Formation of Adapter Dimers
12 Oct 23
Methods of reducing adapter-dimers in a sequencing library are provided according to aspects of the present disclosure, including: hybridizing excess 3′ adapters to blocker oligonucleotides forming a hybridized complex, such that the excess 3′ adapters are unavailable to form adapter-dimers, the hybridized complex including: a first blocker oligonucleotide 3′ terminus adjacent to an adenylated nucleotide at the 5′ terminus of a first unligated 3′ adapter and a second blocker oligonucleotide 3′ terminus adjacent to an adenylated nucleotide at the 5′ terminus of a second unligated 3′ adapter, wherein the first blocker oligonucleotide has a 5′ portion complementary to and hybridized to the first unligated 3′ adapter, the second blocker oligonucleotide has a 5′ portion complementary to and hybridized to the second unligated 3′ adapter, and the first blocker oligonucleotide has a 3′ portion complementary to, and hybridized to, a 3′ portion of the second blocker oligonucleotide.
Kevin D. Allen, Kerry Gunning, Allyson LeBas, Eric Castro
Filed: 24 Mar 23
Utility
Active grinding media for processing samples
3 Oct 23
An active/resilient grinding media inside a tube containing a sample is oscillated rapidly by a homogenizer so that the active media is driven in a first direction until it impacts a first end of the tube, which causes it to deform and store an energy charge as it decelerates and stops, and it then accelerates rapidly in the second opposite direction under the discharging force of the stored energy toward the opposite second end of the tube.
William Z. Todd, Karl Jahn
Filed: 19 Oct 22
Utility
Microfluidic Chip and Electrical Interface for Microchip Electrophoresis
28 Sep 23
A microfluidic system may include a microfluidic chip having a non-conductive substrate and wells connected in common to a microfluidic channel within the non-conductive substrate.
Allen Curtis Dennison, Vladimir Krasheninin, Stephen J. Allen, Thomas Rawlins, Richard Raymond Harazin, Michael W. Belobraydich, Narendra Vaidya, Shreyas Milankumar Shah, Thomas John Martiska
Filed: 22 Mar 22
Utility
Random access sensor with individually addressable transistors
12 Sep 23
A circuit, e.g., a CMOS sensor, with individually addressable transfer transistors and individually addressable reset transistors is described.
Charles Adams Schneider, Jr., Brian Klembara, Rafael Domínguez Castro, Jesús Ruiz Amaya, Jose Angel Segovia de la Torre, Bruno Gili, Ana González Márquez
Filed: 19 Nov 20
Utility
Methods for Separating and Detecting Double-stranded and Single-stranded Ribonucleic Acid (Rna)
7 Sep 23
Provided herein are capillary electrophoresis methods for separating and detecting double-stranded ribonucleic acid (dsRNA) contaminants in samples of single-stranded ribonucleic acids (ssRNA) such as RNA therapies (e.g., mRNA vaccines).
Lloyd Bwanali, Guangnan Meng, Shreyas Shah
Filed: 28 Feb 23
Utility
Compositions and Methods for Performing Magnetibuoyant Separations
31 Aug 23
The methods of the invention employ targeted magnetic particles, preferably targeted nanomagnetic particles, and targeted buoyant particles such as buoyant microparticles and microbubbles.
DHANESH GOHEL, HONG ZHANG, JOHN RANSOM
Filed: 19 Jan 23
Utility
Spectral unmixing for in-vivo imaging
22 Aug 23
Described herein are systems and methods for spectral unmixing of in vivo light data.
Heng Xu, Bradley W. Rice
Filed: 1 Jul 19
Utility
Toroidal Ion Trap
10 Aug 23
Provided are improved toroidal ion traps and methods of design of such ion traps.
Stephen D. Lammert, Atanu K. Mohanty, Shawn Johnson, Robert Jackson
Filed: 3 Feb 23
Utility
Method for Producing Genetically Modified Cells
27 Jul 23
A method for producing genetically engineered immune cells, e.g.
John Lambourne, Immacolata Porreca
Filed: 9 Jul 21
Utility
Discharge chambers and ionization devices, methods and systems using them
18 Jul 23
Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described.
Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
Filed: 6 Jun 21