1042 patents
Utility
FREE BASE CRYSTALLINE FORM OF A COMPLEMENT COMPONENT C5a RECEPTOR
30 Nov 23
Rajinder SINGH, Kwok YAU, Yibin ZENG, Penglie ZHANG, Rebecca M. LUI, Antoni KRASINSKI
Filed: 24 Apr 23
Utility
INTERLEUKIN-21 Mutein/ ANTI-PD-1 Antibody Conjugates
30 Nov 23
Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease.
Khaled M.K.Z. ALI, Neeraj Jagdish AGRAWAL, Gunasekaran KANNAN, Ian FOLTZ, Zhulun WANG, Darren BATES, Marissa MOCK, Shunsuke TAKENAKA
Filed: 1 Dec 22
Utility
Drug Delivery Device Assembly and Accessory for Drug Delivery Device
30 Nov 23
A drug delivery device assembly is provided, including an injector housing, a needle assembly, a drive assembly, and a needle shield indicator accessory.
Jakob Halkjaer Pedersen, Joshua Jay Dudman
Filed: 1 Nov 21
Utility
Drug Delivery Device Assembly and Accessory for Drug Delivery Device
30 Nov 23
A drug delivery device assembly is provided, including an injector housing, a needle assembly, a drive assembly, and a dose feedback accessory.
Carsten Bech, Jakob Halkjaer Pedersen, Joshua Jay Dudman, Adrianus Gerardus Verschuren, Chiushun Dan
Filed: 1 Nov 21
Utility
Drug Delivery Device Assembly and Accessory for Drug Delivery Device
30 Nov 23
A drug delivery device assembly is provided, including an injector housing, a needle assembly, a drive assembly, and an alignment accessory.
Jakob Halkjaer Pedersen, Joshua Jay Dudman, Chiushun Dan, Kasper Friis, Carsten Bech, Adrianus Gerardus Verschuren, Michael John McColligan, Filip Saarman
Filed: 1 Nov 21
Utility
Systems and approaches for sterilizing a drug delivery device
28 Nov 23
A drug delivery sterilization system includes a housing defining at least one receptacle, a container assembly having first and second ends, an elongated portion extending therebetween, and an electron beam or x-ray generator disposed near the housing.
Loic Barbedette, Shaun Devitt, Wael Mismar
Filed: 2 Nov 18
Utility
Systems and approaches for sterilizing a drug delivery device
28 Nov 23
An on-body injector system includes a drug container assembly including a container, a seal member, and a sealing interface between the seal member and the container.
Loic Barbedette, Shaun Devitt, Wael Mismar
Filed: 21 Dec 22
Utility
Solid state forms
28 Nov 23
The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.
Mary Chaves, Patricia Lopez, Prashant Agarwal, Albert Amegadzie, Stephanie Azali, Roman Shimanovich, Ron C. Kelly, Darren Leonard Reid
Filed: 16 Dec 21
Utility
Mammalian cell culture
28 Nov 23
The invention provides a method for culturing mammalian cells.
Brian D. Follstad, Rebecca E. McCoy, Arvia E. Morris
Filed: 8 Mar 23
Utility
Rational Selection of Building Blocks for the Assembly of Multispecific Antibodies
23 Nov 23
The ability to generate a single antibody-based construct that can recognize multiple targets simultaneously, is paramount to advance many therapeutics candidates to clinic.
Danyang GONG, Fernando GARCES, Zhulun WANG
Filed: 5 Oct 21
Utility
Drug Delivery Device with Sterile Fluid Flowpath and Related Method of Assembly
23 Nov 23
Drug delivery devices and related methods of assembly are disclosed.
Yasaman Damestani, Lawrence S. Ring
Filed: 26 Jul 23
Utility
Synthesis of Omecamtiv Mecarbil
23 Nov 23
Sebastien CAILLE, Kyle QUASDORF, Philipp C. ROOSEN, Xianqing SHI, Andrew COSBIE, Fang WANG, Zufan WU, Archana NEERGUNDA, Bin Peter QUAN, Lianxiu GUAN
Filed: 26 Jul 23
Utility
Processes for Preparing a MDM2 Inhibitor
23 Nov 23
The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates thereof.
Sebastien Caille, Michael Corbett, Austin Smith
Filed: 1 Aug 23
Utility
Modulators of chemokine receptors
21 Nov 23
Xi Chen, Dean R. Dragoli, Junfa Fan, Jaroslaw Kalisiak, Antoni Krasinski, Manmohan Reddy Leleti, Venkat Mali, Jeffrey McMahon, Rajinder Singh, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang
Filed: 4 Mar 21
Utility
Diol Desymmetrization by Nucleophilic Aromatic Substitution
16 Nov 23
MATTHEW G. BEAVER, JOSEPH MICHAEL DENNIS, PETER DORNAN, STEVEN MENNEN, JASON S. TEDROW, NEIL F. LANGILLE, CAROLYN MICHELLE COHEN, ANDREAS RENE ROTHELI
Filed: 1 Sep 21
Utility
Machine Learning Techniques for Predicting Thermostability
16 Nov 23
Techniques for computationally screening a set of single-chain variable fragments (scFvs).
Ameya Harmalkar, Kathy Yufeng Wei
Filed: 9 May 23
Utility
Methods of Detecting Isoaspartic Acid
16 Nov 23
Disclosed herein are methods of processing a protein and detecting isoaspartic acid (isoAsp) in a protein.
John On-Ting HUI, Iain David Grant CAMPUZANO
Filed: 30 Sep 21
Utility
Methods for reducing the viscosity of liquid pharmaceutical formulations comprising therapeutic proteins
14 Nov 23
A method for reducing the viscosity of a pharmaceutical formulation is provided that utilizes a viscosity-reducing concentration of an excipient selected from the group consisting of the n-acetyl arginine, n-acetyl lysine, n-acetyl proline and mixtures thereof in combination with a therapeutiv protein.
Christopher James Sloey, Sekhar Kanapuram
Filed: 22 Oct 15
Utility
Drug delivery device including seal member for needle of syringe
14 Nov 23
Drug delivery devices and related methods of assembly are disclosed.
Ronald Forster, Gregory Gordon, Martin Hering, Matthew Wayne Janke, Andrew N. King, Wael Mismar
Filed: 1 Oct 18
Utility
Synthesis of Sulfonamide Intermediates
9 Nov 23
Neil Fred LANGILLE, Jason S. TEDROW, Jonathan Vinh-Phu TRUONG, Robert Ronald MILBURN, Alessandro ARENA
Filed: 28 Apr 21