3525 patents
Page 22 of 177
Utility
Game-theoretic frameworks for deep neural network rationalization
23 May 23
A method and system of determining an output label rationale are provided.
Shiyu Chang, Mo Yu, Yang Zhang, Tommi S. Jaakkola
Filed: 20 Oct 19
Utility
Membranes and anion conductive polymers
23 May 23
A major challenge in the development of anion exchange membranes for fuel cells is the design and synthesis of highly stable (chemically and mechanically) and conducting membranes.
Timothy Manning Swager, Jeffrey C. Grossman, Sibo Lin, Yoonseob Kim, Yanming Wang, Arthur France-Lanord, You-Chi Wu, Yifan Li, Yichong Wang
Filed: 3 Nov 20
Utility
Methods for Generating Engineered Memory-like NK Cells and Compositions Thereof
18 May 23
The present disclosure relates to cytokine-induced memory-like NK cells expressing a chimeric antigen receptor polypeptide that binds to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer.
Jianzhu Chen, Jerome Ritz, Rizwan Romee, Han Dong, Guozhu Xie, James Dongjoo Ham
Filed: 10 Mar 21
Utility
Small Molecule Binders of the Oncogenic Fusion Transcription Factor PAX3-FOXO1
18 May 23
The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety.
Angela Nicole Koehler, Shelby Doyle, Becky Leifer, Matthew Henley, Beat W. Schaefer, Marco Wachtel
Filed: 16 Sep 22
Utility
Foam Reduction And/or Prevention Methods and Associated Systems and Articles
18 May 23
Foam mitigation using a variety of articles, systems, and methods is generally described.
Kripa K. Varanasi, Leonid Rapoport
Filed: 19 Oct 22
Utility
Lipid Compositions for Delivery of Sting Agonist Compounds and Uses Thereof
18 May 23
The present disclosure provides lipid compositions comprising lipid particles (e.g., lipid nanodiscs), wherein the lipid particles (e.g., lipid nanodiscs) comprise a STING agonist amphiphile conjugate, a phospholipid and a PEG-lipid.
Darrell J. IRVINE, Eric DANE, Masanori OKANIWA
Filed: 20 Apr 21
Utility
Methods of Functionality Screening Biological Sequence Fragments
18 May 23
The invention relates, in part, to methods of accurately and reliably detecting biological sequences corresponding to a particular function.
Kevin Michael Esvelt, Dana Gretton
Filed: 23 Jan 21
Utility
Biodegradable Sustainable Polyesters
18 May 23
Disclosed is a copolymer comprising a hydroxyacid, wherein the copolymer is biodegradable with a decomposition temperature is substantially higher than its melting temperature.
Kristala L. Jones Prather, Desiree Plata, Bradley D. Olsen, Wontae Joo, Sarah Av-Ron, K’yal Rasean Bannister, Omar Tantawi
Filed: 8 Nov 22
Utility
Sequencing-based Population Scale Screening
18 May 23
Provided herein are methods and kits for parallel detection one or more target sequences across multiple samples, comprising separating a set of samples into one or more pooled sets, wherein each sample may comprise an initial amplicon comprising one or more target sequences and at least one barcode; conducting an amplification reaction on the one or more pooled sets to further amplify the amplicons, and optionally further adding an additional barcode to the amplicon; sequencing the amplicons; identifying individual samples from the pooled sample set that are positive for the one or more target sequences based on sequencing of the amplicons, wherein identification is based, at least in part, on detection of the unique combination of barcodes.
Feng Zhang, Jonathan Schmid-Burgk, David Li
Filed: 2 Apr 21
Utility
SARS-COV2 Spike Protein Binding Peptides
18 May 23
The disclosure provides peptides that are useful for the prevention of infection of coronaviruses, especially SARS-CoV-2.
Bradley L. Pentelute, Genwei Zhang, Sebastian Pomplun, Alexander R. Loftis, Andrei Loas
Filed: 19 Mar 21
Utility
System and Method for Analyzing and Steering Use of Third-party Libraries
18 May 23
A system for analysis and steering use of online libraries, contains program source code comprising a plurality of modules, at least one third party library, and a processor and a memory configured to store non-transitory instructions that, when executed by the processor, run a module recontextualization application.
Martin C. Rinard, Nikolaos Vasilakis
Filed: 16 Nov 22
Utility
Composite Feature Engineering
18 May 23
A domain of an input dataset is identified and one or more archived domain knowledge features corresponding to the identified domain are identified.
Dakuo Wang, Udayan Khurana, Chuang Gan, Gregory Bramble, Abel Valente, Arunima Chaudhary, Carolina Maria Spina, Micah Smith
Filed: 14 Nov 21
Utility
Thermally controlled residence devices
16 May 23
Residence devices for long term delivery of therapeutic compounds and/or for sensing one or more relevant parameters in vivo are disclosed.
Robert S. Langer, Carlo Giovanni Traverso, Sahab I Babaee, Simo Pajovic, Jiuyun | Shi
Filed: 15 Nov 19
Utility
Controlling metabolism by substrate cofeeding
16 May 23
The disclosure provides methods using mixed substrate cofeeding for bioproduct synthesis, which enables faster, more efficient, and higher yield carbon conversion in various organisms.
Junyoung Park, Nian Liu, Gregory Stephanopoulos
Filed: 29 Jun 18
Utility
Stable binary nanocrystalline alloys and methods of identifying same
16 May 23
Identifying a stable phase of a binary alloy comprising a solute element and a solvent element.
Heather A. Murdoch, Christopher A. Schuh
Filed: 22 Jan 19
Utility
Photovoltaic optical modulators
16 May 23
A photovoltaic modulator utilizes free carriers generated by absorption of optical radiation passing through the modulator to achieve ultra-low energy modulation of the radiation.
Marc De Cea Falco, Amir H. Atabaki, Rajeev J. Ram
Filed: 21 Jun 21
Utility
Visibly transparent, luminescent solar concentrator
16 May 23
A visibly transparent luminescent solar concentrator (LSC) is disclosed.
Richard Royal Lunt, Vladimir Bulovic, Miles Clark Barr
Filed: 20 Nov 20
Utility
Boiling Assisted Channel Templating for Adsorbent Coating Fabrication
11 May 23
A simplified method of making an adsorbent layer can permit design and analysis of sorption systems having improved performance can include generation of one dimensional channels.
Evelyn Wang, Cody Jacobucci, Xiangyu LI, Bachir EL FIL
Filed: 8 Nov 22
Utility
Dopamine D2 Receptor Ligands
11 May 23
The present invention relates to novel dopamine D2 receptor ligands.
Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Edward Scolnick, Michelle Palmer, Luka Dordevic, Michael C. Lewis, Jennifer Q. Pan, Yan-Ling Zhang, Qihong Xu
Filed: 7 Oct 22
Utility
Precision Delivery of Multi-scale Payloads to Tissue-specific Targets In Plants
11 May 23
The invention provides a silk-based biomaterial designed to fabricate a microneedle-like device with controlled degradation rate in planta via tuning material composition and methods of manufacture thereof.
Benedetto MARELLI, Yunteng CAO
Filed: 16 Apr 21