120 patents
Utility
Dual pumping arrangement for a hollow fiber filter
9 Jan 24
A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel.
Rudolf Pavlik
Filed: 2 Aug 22
Utility
Compact High Resolution Monochromatic Light Source for Fluid Sample Concentration Measurement
14 Dec 23
A compact light source for coupling to a movable optic probe may include a light emitting diode (LED), to generate a probe signal at a first bandwidth, an optic coupler, disposed adjacent to the LED, and arranged to couple the probe signal into the movable probe, and a narrow bandpass filter disposed to receive the probe signal at the first bandwidth, and to output the probe signal into the movable probe at a second bandwidth, less than the first bandwidth.
Matthew Muller, Richard Hall, III, Yusheng Zhang, Peter Halatin
Filed: 17 May 23
Utility
AAV8 Affinity Agents
7 Dec 23
Provided herein are affinity ligands that specifically interact with AAV8 capsid and/or AAV8 variant capsid, affinity agents comprising the affinity ligands, and methods of their use for binding, isolation, and/or purification of AAV8 and variants thereof.
Sarmistha Bhattacharya, Brandon Coyle, Sarah Valentini, Kelley Kearns, Thomas Scanlon, William Wellborn, Warren Kett
Filed: 13 Oct 21
Utility
Method of actuation of an alternating tangential flow diaphragm pump
5 Dec 23
A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply.
Rudolf Pavlik
Filed: 24 May 22
Utility
Recovery of Perfusion Bleed Product Via Alternating Tangential Flow Filtration In a Sedimentation Reactor
30 Nov 23
A bleed recovery system for use in a bioreactor system is disclosed.
Charles Hill, Joey Tse, Mario Sinani, Earl Pineda
Filed: 22 May 23
Utility
No-ref-signal Slope Spectroscopic Measurement
23 Nov 23
A method includes determining whether a variation in probe radiation intensity meets a stability criterion; directing the probe radiation through a probe, when the probe is disposed at a first position, defining a first path length L1 of the probe radiation through the fluid sample; measuring a transmitted intensity I1 of the probe radiation after passing through the fluid sample when the probe is disposed at the first position; directing the probe radiation through the probe when the probe is disposed at a second position, defining a second path length L2 of the probe radiation through the fluid sample; measuring a transmitted intensity I2 of the probe radiation after passing through the fluid sample when the probe is disposed at the second position; and determining a concentration C of a material in the fluid sample based upon L1, I1, L2, and I2, when the stability criterion is met.
Matthew Muller, Richard Hall, III, Yusheng Zhang, Peter Halatin
Filed: 17 May 23
Utility
Variable Path Length Absorption Spectrometer Having Automated Continuous Slope Measurement
23 Nov 23
A system may include a light source, to generate a probe signal, comprising incident radiation; an optical probe, to direct the incident radiation through a fluid sample; a motor, to move the optical probe along a probe axis, to change a path length of the incident radiation through the fluid sample; and a detector, to receive the incident radiation as attenuated radiation after passing through the fluid sample.
Matthew Muller, Richard Hall, III, Yusheng Zhang, Peter Halatin
Filed: 17 May 23
Utility
Multi-monochromatic Light Source System for Slope Spectroscopy
23 Nov 23
An apparatus may include a light emitting diode (LED) assembly, comprising a plurality of LEDs that output radiation at a plurality of different wavelengths, respectively.
Matthew Muller, Richard Hall, III, Yusheng Zhang, Peter Halatin
Filed: 17 May 23
Utility
Plunger pumping arrangement for a hollow fiber filter
14 Nov 23
A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel.
Rudolf Pavlik
Filed: 20 Jul 22
Utility
Encapsulated System for Pressurized Fluid Processes
9 Nov 23
Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing.
Michael C. Gagne, Dean C. Richards, Steven V. Cates
Filed: 12 Jul 23
Utility
Sterile Protein a Chromatography Columns
26 Oct 23
If one sterilizes pre-packed, plastic chromatography columns with an appropriate level of gamma irradiation, the resulting sterile chromatography columns maintain sufficient packing media function and maintain column mechanical properties and pressure ratings.
James Ronald Peyser, Dana Cristina Pentia
Filed: 5 Jul 23
Utility
FC Binding Proteins with Cysteine In the C-terminal Helical Region
26 Oct 23
The present invention relates to Fc binding proteins comprising one or more domains with Cysteine in the C-terminal helical region.
Erik Fiedler, Ulrich Haupts
Filed: 7 Dec 22
Utility
Fc binding proteins with cysteine in the C-terminal helical region
10 Oct 23
The present invention relates to Fc binding proteins comprising one or more domains with Cysteine in the C-terminal helical region.
Erik Fiedler, Ulrich Haupts
Filed: 6 Aug 18
Utility
Variable Pathlength Uv Spectroscopy Based Automated TFF System
21 Sep 23
A system for TFF filtration of a feedstock includes a feed vessel containing a solution comprising a target biomolecule, a filter membrane for filtering the solution, a feed pump for moving the solution from the feed vessel to the filter membrane, a buffer vessel coupled to the feed vessel by a buffer supply line, and a diafiltration pump disposed in the buffer supply line for delivering a buffer solution to the feed vessel.
Ramsey Shanbaky, Dodd Weisenberger, Derek Carroll, Paul Lalo, Brandon Goldberg
Filed: 20 Mar 23
Utility
Encapsulated system for pressurized fluid processes
12 Sep 23
Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing.
Michael C. Gagne, Dean C. Richards, Steven V. Cates
Filed: 8 Jun 22
Utility
Filtration Units and Assembly, and Methods of Making and Using Same
17 Aug 23
A self-contained filtration assembly with a self-contained filtration cassette therein.
Mark Perreault, Paul Lowell
Filed: 9 Feb 23
Utility
Encapsulated valve system and method of use
8 Aug 23
An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface.
Michael C. Gagne, Steven V. Cates
Filed: 20 Jul 22
Utility
Systems and Methods for Filtration of Cell Cultures
27 Jul 23
A method of improving volumetric productivity from a cell culture includes filtering a cell culture through an ultrafilter or a microfilter operating in tangential flow filtration mode or alternating flow filtration mode, and filtering the cell culture concurrently or intermittently through a tangential flow depth filtration system to remove cellular debris and/or to harvest cell product.
Shashi Kudugunti, Earl Pineda, Michael Bransby
Filed: 19 Jan 23
Utility
Vessel, System, and Associated Method for Product Concentration
6 Jul 23
Vessel configured to facilitate concentration of a product in a solution.
Steven V. Cates, Rudolf Pavlik, Bao Le
Filed: 30 Nov 22
Utility
Tangential flow depth filtration systems and methods of filtration using same
9 May 23
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Michael Bransby, Derek Carroll
Filed: 31 Mar 21