290 patents
Page 11 of 15
Utility
Methods of Treating Antibody-Mediated Disorders with FcRn Antagonists
28 Jan 21
The present disclosure provides methods of treating an antibody-mediated disorder (e.g., an autoimmune disease) using an FcRn antagonist, e.g., a binding polypeptide (e.g., an antibody and/or an immunoadhesin), comprising a modified Fc domain.
Brian Mackness, Huawei Qiu
Filed: 24 Jul 20
Utility
Methods for absolute quantification of low-abundance polypeptides using mass spectrometry
26 Jan 21
The present invention provides methods for improved label-free absolute quantification of relatively low abundant polypeptides by liquid chromatography/mass spectrometry analysis of peptide products obtained from simple or complex polypeptide mixtures.
Martha Stapels, Michelle Busch
Filed: 1 Jun 18
Utility
Biomarkers of Methotrexate-induced Immune Tolerance
14 Jan 21
The present application provides methods of treating a disease, such as Pompe disease, in a subject, comprising detecting an erythropoiesis biomarker in a sample of the subject after administration of methotrexate and a therapeutic agent to the subject, and administering further treatment with or without concurrently administering additional immune tolerance induction or immunosuppression therapy based on the level of the erythropoiesis biomarker.
Alexandra JOSEPH, Johnson TRAN, Susan M. RICHARDS
Filed: 21 Dec 18
Utility
Gene Therapy for Spinal Cord Disorders
14 Jan 21
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject.
James DODGE, Lamya S. SHIHABUDDIN, Marco A. PASSINI, Seng H. CHENG, Catherine O'RIORDAN
Filed: 24 Jun 20
Utility
Methods for treating Gaucher disease
12 Jan 21
Methods for treating Gaucher disease in patients with renal or hepatic impairment.
Jing Li, M. Judith Peterschmitt, Vanaja Kanamaluru, Jun Chen, Sebastiaan J. M. Gaemers, Dan Rudin
Filed: 13 Dec 18
Utility
Amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
12 Jan 21
Judith Peterschmitt
Filed: 22 Feb 16
Utility
Marker for acid sphingomyelinase disorders and uses thereof
12 Jan 21
The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease.
Wei-Lien Chuang, Gerald F. Cox, X. Kate Zhang
Filed: 8 Jun 18
Utility
Integrated Continuous Isolation of Fluid Streams From Sterile Process Vessels
6 Jan 21
Provided herein are isolation processes and the associated hardware to allow fluid streams to be isolated from a sterilized system (e.g., a sterile process vessel) that contains a sterile process.
Robert Snow
Filed: 20 Sep 20
Utility
Biomarkers of polycystic kidney disease and uses thereof
21 Dec 20
Provided herein are methods for determining the efficacy of treatment for polycystic kidney disease (PKD) in a patient, diagnosing PKD in a patient, staging PKD in a patient, and monitoring PKD in a patient.
Oxana Beskrovnaya, Nikolai Bukanov, Sarah Moreno
Filed: 2 Aug 15
Utility
Methods for Quantifying Drug Concentration In a Prodrug Composition
9 Dec 20
Methods for quantifying the amount of drug present in a prodrug composition are provided.
Kim Alving, Bing Wang
Filed: 5 May 20
Utility
Gene Therapy for Neurodegenerative Disorders
9 Dec 20
Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.
Marco A. PASSINI, Lamya SHIHABUDDIN, Seng H. CHENG
Filed: 17 Feb 20
Utility
Seed Train Processes and Uses Thereof
2 Dec 20
Provided herein are seed train processes and methods of producing a recombinant protein that include the use of these seed train processes.
Michael Bruninghaus, Konstantin Konstantinov, Benjamin Wright, Weichang Zhou
Filed: 23 Feb 20
Utility
Sterile Chromatography and Manufacturing Processes
25 Nov 20
Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column.
Rahul Godawat, Veena Warikoo, Rohan Patil, Konstantin Konstantinov, Venkat Kishore Ryakala, Mahsa Rohani
Filed: 13 Aug 20
Utility
Bone-targeting antibodies
23 Nov 20
Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone.
Huawei Qiu, Sunghae Park, James Stefano
Filed: 18 Jan 18
Utility
Induction of Immune Tolerance by Using Methotrexate
18 Nov 20
The invention provides methods for reducing undesired immune responses, such as anti-drug antibody (ADA) responses and other T- and/or B-cell-mediated immune responses, in patients by using treatment with methotrexate.
Alexandra JOSEPH, Susan RICHARDS, Melanie RUZEK, Richard GARMAN
Filed: 23 Mar 20
Utility
Fc containing polypeptides with altered glycosylation and reduced effector function
16 Nov 20
Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an Fc domain with an altered glycosylation profile and reduced effector function.
Clark Pan, Huawei Qiu
Filed: 11 Sep 17
Utility
Compositions and methods for treating spinal muscular atrophy
2 Nov 20
The present provides methods for treating spinal muscular atrophy using a self-complementary recombinant adeno-associated virus (rAAV) viral particle comprising a transgene expressing SMN.
Marco A. Passini, Lamya S. Shihabuddin, Catherine R. O'Riordan, Seng H. Cheng
Filed: 30 Apr 13
Utility
Adeno-associated viral vectors for treating myocilin (MYOC) glaucoma
2 Nov 20
Provided herein are methods for treating myocilin (MYOC) glaucoma using adeno-associated viral (AAV) vectors.
Peter Pechan, Abraham Scaria, Jeffery Ardinger
Filed: 15 Sep 15
Utility
Fusion proteins and methods for inhibiting IL-17 pathways
2 Nov 20
Fusion proteins including an IL-17 receptor with a multimerization domain, or an IL-23 receptor and a multimerization domain, and recombinant viral vectors encoding such fusions, are described.
Abraham Scaria, Gary White
Filed: 24 Mar 10
Utility
Production of oversized adeno-associated vectors
26 Oct 20
Provided herein are methods for producing an adeno-associated virus (AAV) particle containing an oversized recombinant AAV genome (e.g., greater than 4.7 kb).
Sirkka Kyostio-Moore, David Souza, Karen Vincent
Filed: 6 Apr 16