290 patents
Page 15 of 15
Utility
Fusion Proteins Comprising PDGF and Vegf Binding Portions and Methods of Using Thereof
13 Nov 19
The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins.
Peter Pechan, Jeffery Ardinger, Hillard Rubin, Samuel Wadsworth, Abraham Scaria
Filed: 19 Nov 18
Utility
Perfusion Bioreactor With Filtration Systems
6 Nov 19
The disclosure provides a filtration system for a cell culture apparatus and a method of cell culture.
Jiuyi Lu, Jason Walther, Jonathan Wang, Kevin Victor Chen
Filed: 2 May 19
Utility
Oligosaccharide-protein conjugates
4 Nov 19
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI.
Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
Filed: 6 Oct 16
Utility
Slow Intraventricular Delivery
30 Oct 19
Neurological diseases, including lysosomal storage diseases, can be successfully treated using intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier.
James C. DODGE, Marco A. PASSINI, Lamya S. SHIHABUDDIN, Seng H. CHENG
Filed: 20 Feb 19
Utility
Quinazoline derivatives as VEGF inhibitors
28 Oct 19
Andrew Peter Thomas, Elaine Sophie Elizabeth Stokes, Laurent Francois Andre Hennequin
Filed: 27 Dec 17
Utility
Synthesis of Udp-glucose: N-acylsphingosine Glucosyltransferase Inhibitors
23 Oct 19
Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase.
Bradford H. HIRTH, Craig Siegel
Filed: 20 Nov 18
Utility
Variant RNAi
21 Oct 19
Provided herein are RNAi molecules including a first strand containing a guide sequence and a second strand comprising a non-guide sequence where the non-guide sequence contains a bulge opposite the seed region of the guide sequences; e.g., opposite the cleavage sequence.
Lisa M. Stanek, Adam Palermo, Brenda Richards, Sergio Pablo Sardi, Catherine O'Riordan, Antonius Song
Filed: 8 Feb 16
Utility
Aav Virions with Decreased Immunoreactivity and Uses Therefor
16 Oct 19
Methods of making and using recombinant AAV virions with decreased immunoreactivity are described.
Alejandra E. ARBETMAN, Peter C. COLOSI, Michael A. LOCHRIE, Richard T. SUROSKY
Filed: 28 Jan 19
Utility
Novel Beta-actin and RPS21 Promoters and Uses Thereof
2 Oct 19
The invention relates to isolation of novel β-actin and ribosomal protein S21 (rpS21) promoters and uses thereof.
Scott D. ESTES, Weiqun ZHANG
Filed: 11 Mar 19
Utility
Analytical ultracentrifugation for characterization of recombinant viral particles
30 Sep 19
Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation.
Catherine R. O'Riordan, Brenda Burnham
Filed: 18 Jan 16