290 patents
Page 3 of 15
Utility
Methods for detecting AAV
11 Jul 23
Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle).
Xiaoying Jin, Catherine O'Riordan, Lin Liu, Kate Zhang
Filed: 14 Aug 17
Utility
Early post-transfection isolation of cells (EPIC) for biologics production
27 Jun 23
Provided herein are methods for selecting a population of cells expressing a target polypeptide.
Victor R. Cairns, Christine DeMaria, Jason Vitko
Filed: 14 Nov 19
Utility
Methods and Compositions for Treating a Bleeding Event In a Subject Having Hemophilia
25 May 23
The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to treat a bleeding event in a subject having a hemophilia (e.g., with or without inhibitors).
Akin Akinc
Filed: 1 Aug 22
Utility
Arylamides and Methods of Use Thereof
25 May 23
The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof.
Junkai Liao, Mark Munson, Zhongli Gao, Gregory Hurlbut, Hans Peter Nestler, Helen Yeoman, Martin Smrcina, Ronghua Li, Ryan Hartung, William Wire, Bertrand Vivet, Nina Ma
Filed: 3 Jun 22
Utility
Arylamides and Methods of Use Thereof
25 May 23
The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof.
Junkai Liao, Mark Munson, Zhongli Gao, Gregory Hurlbut, Hans Peter Nestler, Ingrid Mechin, Joseph Kim, Martin Smrcina, Nina Ma, Ronghua Li, Ryan Hartung, William Bock, Bertrand Vivet
Filed: 3 Jun 22
Utility
CRYSTALLINE IMIDAZO[4,5-b]PYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE IN TREATING MEDICAL CONDITIONS
18 May 23
The invention provides a crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, methods of inhibiting tropomyosin-related kinase and/or c-FMS, and methods of treating medical diseases and conditions, such as pain.
Benoit ROBERT
Filed: 11 Nov 22
Utility
Treatment of Osteogenesis Imperfecta
11 May 23
The present disclosure provides methods for treating and improving b1osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of an agent that binds and neutralizes transforming growth factor beta (TGF-β).
Panteleimon D. MAVROUDIS, Nikhil PILLAI, Qingping WANG
Filed: 31 Oct 22
Utility
Arylamides and Methods of Use Thereof
11 May 23
The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof.
Junkai Liao, Mark Munson, Zhongli Gao, Gregory Hurlbut, Hans Peter Nestler, Ingrid Mechin, Martin Smrcina, Ronghua Li, Ryan Hartung, William Bock, Bertrand Vivet, Andrew Scholte
Filed: 3 Jun 22
Utility
Gene Therapy For Neurodegenerative Disorders
4 May 23
Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.
Marco A. PASSINI, Lamya Shihabuddin, Seng H. Cheng
Filed: 10 Nov 22
Utility
6-MEMBERED Heteroarylaminosulfonamides for Treating Diseases and Conditions Mediated by Deficient CFTR Activity
4 May 23
The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof.
Zhongli Gao, Gregory Hurlbut, Mark Munson, Junkai Liao
Filed: 11 May 22
Utility
Analytical ultracentrifugation for characterization of recombinant viral particles
2 May 23
Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation.
Catherine R. O'Riordan, Brenda Burnham
Filed: 21 Aug 19
Utility
Thyroid Stimulating Hormone Compositions
27 Apr 23
Described herein are compositions of Thyroid Stimulating Hormone (TSH), wherein at least one polyalkylene glycol polymer is attached to a carbohydrate site of the TSH.
Clark PAN, Huawei QIU, Sunghae PARK
Filed: 23 May 22
Utility
FLARE (flow cytometry attenuated reporter expression) technology for rapid bulk sorting
25 Apr 23
Provided herein are methods and compositions for batch production of producer cells using fluorescence activated cell sorting (FACS).
Victor R. Cairns, Jose Ignacio Sancho Chavida, Christine DeMaria
Filed: 7 Oct 16
Utility
TROPOMYOSIN-RELATED KINASE (trk) INHIBITORS
16 Mar 23
Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease.
John L. Kane, JR., Gloria Matthews, Markus Metz, Michael Kothe, Jinyu Liu, Andrew Scholte
Filed: 8 Aug 22
Utility
Antibodies to TGF-Beta
16 Mar 23
The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ) and uses thereof.
Steven R. Ledbetter, Celia Patricia Hart, Robert G. Holgate, Lutz U. Jermutus, Catriona L. Buchanan, Alexander R. Duncan, Donna K. Finch
Filed: 16 Sep 22
Utility
Gene Therapy For Neurodegenerative Disorders
16 Mar 23
Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.
Marco A. PASSINI, Lamya Shihabuddin, Seng H. Cheng
Filed: 13 Oct 22
Utility
Variant RNAi
14 Mar 23
Provided herein are RNAi molecules for treating Huntington's disease.
Catherine R. O'Riordan, Adam Palermo, Brenda Richards, Lisa M. Stanek
Filed: 21 Sep 18
Utility
Anti-tgf-beta Antibody Formulations and Their Use
2 Feb 23
The present disclosure provides pharmaceutical compositions comprising anti-TGF-β antibodies and methods of use thereof.
Kiran Rana BANGARI, Ramil LATYPOV, Timothy MCCOY, Sanket PATKE
Filed: 17 Jun 22
Utility
Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders
17 Jan 23
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject.
James Dodge, Lamya Shihabuddin, Catherine O'Riordan
Filed: 20 Aug 19
Utility
Chemokine Receptor Binding Heterocyclic Compounds with Enhanced Efficacy
29 Dec 22
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings.
Gary J. Bridger, Renato T. Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason B. Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis Smith, Maria Rosaria Di Fluri
Filed: 13 Jan 22