187 patents
Page 4 of 10
Utility
Methods for Treating Osteogenesis Imperfecta
23 Jun 22
The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a binding agent that binds to transforming growth factor beta (TGFβ).
Brendan Lee, Kuber T. Sampath
Filed: 9 Dec 21
Utility
Assays for Detecting the Presence or Amount of an Anti-drug Antibody
16 Jun 22
Methods and kits for detecting antibodies (e.g., anti-drug antibodies).
Ryan Grabert, Susan Richards, Valerie Theobald, Yuanxin Xu, Jad Zoghbi
Filed: 23 Nov 21
Utility
Methods of Culturing a Mammalian Cell
12 May 22
Provided herein are methods of culturing a mammalian cell in a liquid medium including poloxamer-188 at a concentration of 1.8 g/L or at a greater concentration than 1.8 g/L more or a liquid medium that includes a poloxamer-188 concentration that is selected based on one or more factors selected from the group of: pore size, pore type, gas flow rate, viable cell density in the medium, and markers related to cell stress.
Christopher Hwang, Timothy Johnson, Jason Walther, Cheng Cheng, Jonathan Wang, Neha Shah, Seul-A Bae
Filed: 11 Jan 22
Utility
Site-specific Glycoengineering of Targeting Moieties
21 Apr 22
The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide.
Luis AVILA, Clark PAN, Huawei QIU, Qun ZHOU
Filed: 29 Mar 21
Utility
Treatment of Ciliopathies Using Inhibitors of Glucosylceramide Synthase (GCS)
14 Apr 22
This disclosure relates to a method of treating a ciliopathy in a subject, the method comprising administering to the subject an effective amount of a quinuclidine compound.
Oxana IBRAGHIMOV-BESKROVNAYA, Nikolay O. BUKANOV, Hervé HUSSON, Sarah E. MORENO
Filed: 4 Feb 20
Utility
Pharmaceutical Formulations of Tropomyosin Related Kinase (TRK) Inhibitors
14 Apr 22
Pharmaceutical formulations with a tropomyosin-related kinase inhibitor (“Trk inhibitor”) are disclosed.
Harvey Lieberman, Donglai Yang, C. Michael Philbrook, Michael Santos, Chris Ho
Filed: 20 Aug 21
Utility
Human Pah Expression Cassette for Treatment of Pku by Liver-directed Gene Replacement Therapy
14 Apr 22
Provided herein are expression cassettes for expressing a transgene in a liver cell, wherein the transgene encodes a PAH polypeptide.
Sirkka R.M. KYOSTIO-MOORE
Filed: 30 Sep 21
Utility
Methods for Enhancing Immunosuppressive Therapy by Multiple Administration of Alpha Beta Tcr-binding Polypeptide
31 Mar 22
The present disclosure is related to improved methods for use of a humanized binding polypeptide specific for the alpha beta T cell receptor (αβ-TCR).
Gregor Blank, Rubert Handgretinger, Karin Schilbach, Gina Lacorcia, Daniel Snell, Andreas Menrad
Filed: 8 Sep 21
Utility
Multivariate Spectral Analysis and Monitoring for Biomanufacturing
31 Mar 22
The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.
Dhanuka Pulasthi Wasalathanthri, Jagdish C. Tewari, Xuezhen Kang, Marina Hincapie, Shawn L. Barrett, Julie Susanne Pollock
Filed: 7 Dec 21
Utility
Glycoengineered Antibody Drug Conjugates
24 Mar 22
The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide.
Luis Z. Avila, Qun Zhou
Filed: 16 Aug 21
Utility
Tangential Viral Filtration
24 Mar 22
Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.
Tarl Vetter, Kevin Brower
Filed: 7 Dec 21
Utility
Site-specific Antibody-drug Conjugation Through Glycoengineering
24 Mar 22
The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide.
Clark Pan, Qun Zhou, James Stefano, Pradeep Dhal, Bo Chen, Diego Gianolio, Robert Miller, Huawei Qiu
Filed: 17 Aug 21
Utility
SERPINC1 iRNA Compositions and Methods of Use Thereof
17 Mar 22
The invention relates to pharmaceutical compositions comprising an iRNA agent, e.g., double stranded ribonucleic acid (dsRNA) agent and methods of using such compositions to treat a bleeding event in a subject having a hemophilia (e.g., with or without inhibitors).
Akin Akinc
Filed: 16 Jan 20
Utility
Integrated Continuous Isolation of Fluid Streams From Sterile Process Vessels
17 Mar 22
Provided herein are isolation processes and the associated hardware to allow fluid streams to be isolated from a sterilized system (e.g., a sterile process vessel) that contains a sterile process.
Robert Snow
Filed: 24 Nov 21
Utility
Glucosylceramide Synthase Inhibitors
10 Mar 22
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
Elyse BOURQUE, Mario A. CABRERA-SALAZAR, Cassandra CELATKA, Seng H. CHENG, Bradford HIRTH, Andrew GOOD, Katherine JANCSICS, John MARSHALL, Markus METZ, Ronald K. SCHEULE, Renato SKERLJ, Yibin XIANG, Zhong ZHAO, John LEONARD, Thomas NATOLI, Elina MAKINO, Herve HUSSON, Oxana BESKROVNAYA
Filed: 14 Apr 21
Utility
Perfusion Bioreactor With Filtration Systems
10 Mar 22
The disclosure provides a filtration system for a cell culture apparatus and a method of cell culture.
Jiuyi Lu, Jason Walther, Jonathan Wang, Kevin Victor Chen
Filed: 11 Nov 21
Utility
Fusion Proteins Comprising PDGF and Vegf Binding Portions and Methods of Using Thereof
3 Mar 22
The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins.
Peter PECHAN, Jeffery ARDINGER, Hillard RUBIN, Samuel WADSWORTH, Abraham SCARIA
Filed: 2 Jul 21
Utility
Recombinant Glycoproteins and Uses Thereof
3 Mar 22
Provided herein are recombinant glycoproteins (e.g., recombinant human α-galactosidase-A proteins) with an altered (e.g., improved) glycosylation profile, and pharmaceutical compositions and kits including one or more of these proteins.
Karen Lee, Christopher Hwang, Christine DeMaria
Filed: 22 Sep 21
Utility
Gene Therapy for Retinitis Pigmentosa
24 Feb 22
Provided herein are methods for treating retinitis pigmentosa using an AAV particles encoding miR-708.
Catherine O'RIORDAN, Matthew ADAMOWICZ
Filed: 22 Jul 21
Utility
FGFR3 Antibodies and Methods of Use
24 Feb 22
Anti-FGFR3 antigen-binding proteins and antigen-binding binding fragments thereof are provided.
Yves SABBAGH, Yangde CHEN, William BRONDYK, Huawei QIU, Sunghae PARK, Ronnie WEI, Yu QIU, Yanfeng ZHOU, Cendrine LEMOINE, HyunSuk CHO
Filed: 20 Aug 21