187 patents
Page 8 of 10
Utility
Induction of Immune Tolerance by Using Methotrexate
18 Nov 20
The invention provides methods for reducing undesired immune responses, such as anti-drug antibody (ADA) responses and other T- and/or B-cell-mediated immune responses, in patients by using treatment with methotrexate.
Alexandra JOSEPH, Susan RICHARDS, Melanie RUZEK, Richard GARMAN
Filed: 23 Mar 20
Utility
Integrated Continuous Manufacturing of Therapeutic Protein Drug Substances
7 Oct 20
Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance.
Konstantin Konstantinov, Rahul Godawat, Veena Warikoo, Sujit Jain
Filed: 21 Jun 20
Utility
Continuous Production of Recombinant Proteins
7 Oct 20
The present disclosure relates to methods and systems for the continuous production of recombinant proteins.
Michael Coolbaugh, Tarl Vetter, Chad Varner, Kevin Brower
Filed: 31 Mar 20
Utility
Gene Therapy for Neurometabolic Disorders
30 Sep 20
The disclosure pertains to methods and compositions for treating disorders affecting the central nervous system (CNS).
Marco A. PASSINI, James DODGE
Filed: 2 Mar 20
Utility
Treatment of Multiple Sclerosis with Anti-CD52 Antibodies
23 Sep 20
The present invention relates to treatment of relapsing and progressive forms of multiple sclerosis using a humanized anti-human CD52 IgG1 monoclonal antibody.
David H. MARGOLIN
Filed: 19 Apr 18
Utility
Methods of Controlling the Formation of Disulfide Bonds in Protein Solutions
23 Sep 20
Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess.
Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Jin Yin, Marcella Yu
Filed: 7 Apr 20
Utility
Early Post-transfection Isolation of Cells (Epic) for Biologics Production
23 Sep 20
Provided herein are methods for selecting a population of cells expressing a target polypeptide.
Victor R. Cairns, Christine DeMaria, Jason Vitko
Filed: 13 Nov 19
Utility
Tangential Viral Filtration
16 Sep 20
Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.
Tarl Vetter, Kevin Brower
Filed: 10 Mar 20
Utility
Quinazoline Derivatives as VEGF Inhibitors
19 Aug 20
Andrew Peter Thomas, Elaine Sophie Elizabeth Stokes, Laurent Francois Andre Hennequin
Filed: 24 Sep 19
Utility
Adeno-associated Viral Vectors for Treating Mucolipidosis Type II
19 Aug 20
Provided herein are recombinant adeno-associated virus (rAAV) vectors comprising nucleic acid encoding N-acetyl-glucosamine-1-phosphate transferase, alpha and beta subunits (GNPTAB) and at least one AAV inverted terminal repeat (ITR).
Nelson YEW, Dong-Kyu JIN
Filed: 13 Dec 16
Utility
Antibodies with Enhanced Antibody-dependent Cellular Cytotoxicity Activity, Methods of Their Production and Use
12 Aug 20
The invention relates, in part, to antibodies with increased ADCC activity.
Daniel Schindler, Harry M. Meade, Timothy Edmunds, John McPherson
Filed: 20 Feb 20
Utility
Methods of Perfusion Culturing Using a Shake Flask and Microcarriers
12 Aug 20
Provided herein are methods of perfusion culturing an adherent mammalian cell using a shake flask and a plurality of microcarriers, and various methods that utilize these culturing methods.
Jianguo Yang, Yang Yang, Jennifer Tengtrakool, Weichang Zhou
Filed: 1 Mar 20
Utility
Recombinant Aav Vectors Expressing Osteoprotective Genes, Including HAS2 and Lubricin, Useful In the Treatment of Osteoarthritis and Related Joint Conditions In Mammals
22 Jul 20
The present disclosure relates to recombinant viral vectors, to pharmaceutical compositions comprising such recombinant vectors, and to methods for prevention and treatment of osteoarthritis in mammals.
Monica DIAS FIGUEIREDO, Sirkka RM KYOSTIO-MOORE, Patricia BERTHELETTE
Filed: 28 Jul 19
Utility
Analytical Ultracentrifugation for Characterization of Recombinant Viral Particles
15 Jul 20
Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation.
Catherine R. O'RIORDAN, Brenda BURNHAM
Filed: 20 Aug 19
Utility
Oligosaccharide-protein Conjugates
8 Jul 20
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI.
Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG
Filed: 23 Sep 19
Utility
SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
8 Jul 20
The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia.
Akin Akinc, Alfica Sehgal, Ivanka Toudjarska, Donald Foster, Stuart Milstein, Brian Bettencourt, Martin A. Maier, Klaus Charisse, Satyanarayana Kuchimanchi, Kallanthottathil G. Rajeev, Muthiah Manoharan
Filed: 13 Dec 18
Utility
VARIANT RNAi
8 Jul 20
Provided herein are RNAi molecules for treating Huntington's disease.
Catherine R. O'RIORDAN, Adam PALERMO, Brenda RICHARDS, Lisa M. STANEK
Filed: 20 Sep 18
Utility
Methods for Treating Proteinopathies
24 Jun 20
This disclosure relates to a method of treating a proteinopathy in a subject, the method comprising administering to the subject an effective amount of a quinuclidine compound.
Seng H. CHENG, Lamya SHIHABUDDIN, Sergio Pablo SARDI
Filed: 1 Mar 20
Utility
Method of Preparing Glucosylceramide Synthase Inhibitors
10 Jun 20
This invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Craig S. SIEGEL, Rayomand GIMI, Michael REARDON, Jin ZHAO
Filed: 13 Feb 20
Utility
Methods and Compositions for Treating a Bleeding Event In a Subject Having Hemophilia
27 May 20
The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to treat a bleeding event in a subject having a hemophilia (e.g., with or without inhibitors).
Akin AKINC
Filed: 9 Jul 18