103 patents
Page 4 of 6
Utility
Method of preparing glucosylceramide synthase inhibitors
23 Mar 21
This invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Craig S. Siegel, Rayomand Gimi, Michael Reardon, Jin Zhao
Filed: 14 Feb 20
Utility
Methods for treating cancer
23 Mar 21
The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy.
Paula Marie Ragan, Robert D. Arbeit, Kieran James Crowley
Filed: 14 Dec 16
Utility
Anti-complement factor BB antibodies and uses thereof
2 Mar 21
The present disclosure provides anti-complement factor Bb antibodies, and compositions comprising the antibodies.
Sandip Panicker, Graham Parry, Karen Sue Christopherson, Tony SangYoung Byun
Filed: 3 Apr 17
Utility
Sterile chromatography resin and use thereof in manufacturing processes
16 Feb 21
Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation.
Rahul Godawat, Veena Warikoo, Rohan Patil, Konstantin Konstantinov, Venkat Kishore Ryakala
Filed: 21 Aug 18
Utility
Affinity-based analytical purification of biotherapeutics for bioprocess monitoring
16 Feb 21
The invention as disclosed herein provides a method for purifying a non-antibody protein from solution, comprising a chromatography step wherein the solution is passed over an affinity construct containing an affinity ligand-coupled solid support, wherein the affinity construct is associated with a bioprocess unit operation, and isolating the non-antibody protein from solution.
Veena Warikoo, Kevin Brower
Filed: 4 Dec 17
Utility
Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders
16 Feb 21
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject.
Catherine O'Riordan, Samuel Wadsworth
Filed: 29 Dec 17
Utility
Gene therapy for neurometabolic disorders
9 Feb 21
The disclosure pertains to methods and compositions for treating disorders affecting the central nervous system (CNS).
Marco A. Passini, Greg Stewart, James C. Dodge
Filed: 1 Jul 16
Utility
Oligosaccharides comprising an aminooxy group and conjugates thereof
2 Feb 21
The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group.
Yunxiang Zhu, Seng H. Cheng, Canwen Jiang, Luis Z. Avila
Filed: 6 Feb 19
Utility
Methods for absolute quantification of low-abundance polypeptides using mass spectrometry
26 Jan 21
The present invention provides methods for improved label-free absolute quantification of relatively low abundant polypeptides by liquid chromatography/mass spectrometry analysis of peptide products obtained from simple or complex polypeptide mixtures.
Martha Stapels, Michelle Busch
Filed: 1 Jun 18
Utility
Methods for treating Gaucher disease
12 Jan 21
Methods for treating Gaucher disease in patients with renal or hepatic impairment.
Jing Li, M. Judith Peterschmitt, Vanaja Kanamaluru, Jun Chen, Sebastiaan J. M. Gaemers, Dan Rudin
Filed: 13 Dec 18
Utility
Amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
12 Jan 21
Judith Peterschmitt
Filed: 22 Feb 16
Utility
Marker for acid sphingomyelinase disorders and uses thereof
12 Jan 21
The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease.
Wei-Lien Chuang, Gerald F. Cox, X. Kate Zhang
Filed: 8 Jun 18
Utility
Biomarkers of polycystic kidney disease and uses thereof
21 Dec 20
Provided herein are methods for determining the efficacy of treatment for polycystic kidney disease (PKD) in a patient, diagnosing PKD in a patient, staging PKD in a patient, and monitoring PKD in a patient.
Oxana Beskrovnaya, Nikolai Bukanov, Sarah Moreno
Filed: 2 Aug 15
Utility
Bone-targeting antibodies
23 Nov 20
Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone.
Huawei Qiu, Sunghae Park, James Stefano
Filed: 18 Jan 18
Utility
Fc containing polypeptides with altered glycosylation and reduced effector function
16 Nov 20
Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an Fc domain with an altered glycosylation profile and reduced effector function.
Clark Pan, Huawei Qiu
Filed: 11 Sep 17
Utility
Compositions and methods for treating spinal muscular atrophy
2 Nov 20
The present provides methods for treating spinal muscular atrophy using a self-complementary recombinant adeno-associated virus (rAAV) viral particle comprising a transgene expressing SMN.
Marco A. Passini, Lamya S. Shihabuddin, Catherine R. O'Riordan, Seng H. Cheng
Filed: 30 Apr 13
Utility
Adeno-associated viral vectors for treating myocilin (MYOC) glaucoma
2 Nov 20
Provided herein are methods for treating myocilin (MYOC) glaucoma using adeno-associated viral (AAV) vectors.
Peter Pechan, Abraham Scaria, Jeffery Ardinger
Filed: 15 Sep 15
Utility
Fusion proteins and methods for inhibiting IL-17 pathways
2 Nov 20
Fusion proteins including an IL-17 receptor with a multimerization domain, or an IL-23 receptor and a multimerization domain, and recombinant viral vectors encoding such fusions, are described.
Abraham Scaria, Gary White
Filed: 24 Mar 10
Utility
Production of oversized adeno-associated vectors
26 Oct 20
Provided herein are methods for producing an adeno-associated virus (AAV) particle containing an oversized recombinant AAV genome (e.g., greater than 4.7 kb).
Sirkka Kyostio-Moore, David Souza, Karen Vincent
Filed: 6 Apr 16
Utility
Targeting of glycoprotein therapeutics
5 Oct 20
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described.
James Stefano
Filed: 26 Jul 18