154 patents
Page 2 of 8
Utility
Treating Refractory Migraine
3 Aug 23
Disclosed herein are methods of treating or reducing incidence of migraine and/or at least one secondary symptom associated with refractory migraine in a subject having refractory migraine comprising administering to the subject a monoclonal antibody that modulates the CGRP pathway.
Marcelo Bigal, Ernesto Aycardi
Filed: 17 Feb 23
Utility
Antagonist Antibodies Directed Against Calcitonin Gene-Related Peptide and Methods Using Same
27 Jul 23
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms and/or headaches (e.g., migraine, cluster headache, and tension headache) by administering an anti-CGRP antagonist antibody.
Marcelo Bigal, Sarah Walter, Henry Stern, Michael Chang
Filed: 12 Jul 22
Utility
Solid State Forms of Ensartinib and Ensartinib Salts
20 Jul 23
The present disclosure encompasses solid state forms and co-crystals of Ensartinib and of Ensartinib salts, in embodiments crystalline polymorphs of Ensartinib and of Ensartinib salts and co-crystals, processes for preparation thereof, and pharmaceutical compositions thereof.
Petar Bibulic, Sanja Matecic Musanic, Lorena Kordic
Filed: 3 Aug 21
Utility
Injection Spring for Aged Prefilled Syringe and Auto Injector
25 May 23
An auto injector apparatus includes a syringe and an auto injector.
Paul Andrew Christopher Gibson, Edward Andrew Cummings
Filed: 12 Dec 22
Utility
Solid State Forms of Belumosudil and Belumosudil Salts
20 Apr 23
The present disclosure encompasses solid state forms of Belumosudil, in embodiments crystalline polymorphs of Belumosudil or salts thereof, processes for preparation thereof, and pharmaceutical compositions thereof.
Polina Lapido, Inbal Shumacher, Ofir Shaul
Filed: 6 Dec 22
Utility
Solid State Forms of Avapritinib and Process for Preparation Thereof
6 Apr 23
The present disclosure encompasses solid state forms of Avapritinib, in embodiment crystalline polymorphs of Avapritinib, processes for preparation thereof, and pharmaceutical compositions thereof.
Anantha Rajmohan Muthusamy, Amit Singh, Sundara Lakshmi Kanniah, Vaibhav Suresh Daund, Parven Kumar Luthra, Yogesh Dhananjay Wagh, Meenakshi Sundaram Somasundaram
Filed: 11 Mar 21
Utility
Processes for the Preparation of Glasdegib and Salt Thereof and Solid State Forms of Glasdegib Maleate and Process for Preparation Thereof
6 Apr 23
The present disclosure relates to safe and efficient processes for the synthesis of Glasdegib or salts thereof, preferably Glasdegib Maleate.
Anantha Rajmohan Muthusamy, Amit Singh, Rajendra Popat Chemate, Bhatu Tumba Patil, Elluru Subbi Reddy, Parven Kumar Luthra, Sanjay Lakhabhai Vasoya, Dnyaneshwar Kondibhau Nighot
Filed: 28 Jan 21
Utility
Solid State Forms of Mitapivat and Process for Preparation Thereof
30 Mar 23
Solid state forms of Mitapivat, Mitapivat hemisulfate, Mitapivat HCl, Mitapivat phosphate, Mitapivat hemisulfate:ascorbic acid and Mitapivat hemisulfate:adipic acid, processes for preparation thereof, pharmaceutical compositions there-of, and uses thereof are disclosed.
Polina Lapido, Doron Rudik, Ofir Shaul
Filed: 28 Jan 21
Utility
Solid State Forms of Asciminib and Processes for the Preparation Thereof
30 Mar 23
The present disclosure encompasses solid state forms of Asciminib and salts thereof, in embodiments crystalline poly-morphs of Asciminib and salts thereof, processes for preparation thereof, and pharmaceutical compositions thereof.
Nikolina Janton, Helena Ceric
Filed: 28 Jan 21
Utility
Solid State Forms of Avasopasem Manganese and Process for Preparation Thereof
9 Mar 23
The present disclosure encompasses solid state forms of Avasopasem manganese, in embodiments crystalline polymorphs of Avasopasem manganese, processes for preparation thereof, and pharmaceutical compositions thereof.
Anantha Rajmohan Muthusamy, Amit Singh, Yogesh Dhananjay Wagh
Filed: 12 Feb 21
Utility
Solid State Forms of Mavacamten and Process for Preparation Thereof
23 Feb 23
The present disclosure encompasses solid state forms of Mavacamten, in embodiments crystalline polymorphs of Mavacamten, processes for preparation thereof, and pharmaceutical compositions thereof.
Lorena Kordic, Dijana Skalec Samec
Filed: 28 Jan 21
Utility
Solid State Forms of Blarcamesine Salts
23 Feb 23
The present disclosure encompasses a novel solid state form of Blarcamesine and salts thereof, processes for preparation thereof, and pharmaceutical compositions thereof.
Polina Lapido, Jenny Goldshtein
Filed: 3 Feb 21
Utility
Solid state forms of voclosporin
21 Feb 23
Pavel Kolesa, Ladislav Cvak, Alexandr Jegorov, Katerina Ondruszova
Filed: 21 Oct 19
Utility
Treating headache comprising administering an antibody to calcitonin gene-related peptide
17 Jan 23
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms and/or headaches (e.g., migraine, cluster headache, and tension headache) by administering an anti-CGRP antagonist antibody.
Marcelo Bigal, Sarah Walter, Henry Stern, Michael Chang
Filed: 7 Nov 19
Utility
Injection spring for aged prefilled syringe and auto injector
3 Jan 23
A method of adapting an auto injector configured to actuate a prefilled syringe, the auto injector having a biasing member having a spring constant, the prefilled syringe being filled with a volume of therapeutic fluid, the prefilled syringe including a barrel, stopper, and a needle, the stopper having a path of travel, the biasing member arranged to move the stopper along the path of travel.
Paul Andrew Christopher Gibson, Edward Andrew Cummings
Filed: 19 Sep 19
Utility
Solid State Forms of Lucerastat and Process for Preparation Thereof
29 Dec 22
The present disclosure encompasses solid state forms of Lucerastat, in embodiments crystalline Lucerastat: L-Pyroglutamic acid, crystalline Lucerastat: Salicylic acid, crystalline Lucerastat: Fumaric acid, crystalline Lucerastat: Benzoic acid and crystalline Lucerastat: o-Acetylsalicylic acid, solid state form thereof, processes for preparation thereof, and pharmaceutical compositions thereof.
Anantha Rajmohan Muthusamy, Sundara Lakshmi Kanniah, Yogesh Dhananjay Wagh
Filed: 23 Sep 20
Utility
Solid State Forms of ARRY-797 and Process for Preparation Thereof
1 Dec 22
The present disclosure encompasses solid state forms of Arry-797, in embodiments crystalline polymorphs or salts or co-crystals of Arry-797, processes for preparation thereof, and pharmaceutical compositions thereof.
Dijana Skalec Samec, Valentina Travancic
Filed: 28 Oct 20
Utility
Solid State Forms of Fezagepras and Process for Preparation Thereof
1 Dec 22
The present disclosure encompasses solid state forms of Setogepram, in embodiments crystalline polymorphs or salts of Setogepram, particularly Setogepram sodium, processes for preparation thereof, and pharmaceutical compositions thereof.
Anantha Rajmohan Muthusamy, Amit Singh, Venkata Subbarao Yazali
Filed: 27 Oct 20
Utility
Solid State Forms of Pemafibrate
24 Nov 22
The present disclosure relates to solid state forms of Pemafibrate processes for preparation thereof and pharmaceutical compositions thereof.
Pavel Kolesa, Andrea Colombo, Ettore Marzorati
Filed: 19 Jul 22
Utility
Solid State Forms of Roluperidone and Salts Thereof
10 Nov 22
The present disclosure relates to solid state forms of roluperidone and salts thereof, processes for preparation thereof, and pharmaceutical compositions thereof.
Dijana Skalec Samec, Lorena Kordic
Filed: 29 Jun 20