129 patents
Utility
Pharmaceutical Composition Comprising Eicosapentaenoic Acid and Derivatives Thereof and a Statin
18 Jan 24
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and a statin and to methods of using the same to treat or prevent cardiovascular-related diseases.
George Grandolfi
Filed: 6 Jan 23
Utility
Methods of Reducing the Risk of a Cardiovascular Event In a Subject on Statin Therapy
26 Oct 23
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
Paresh Soni
Filed: 30 Jun 23
Utility
Co-administration of Atorvastatin and Ethyl Eicosapentaenoic Acid or a Derivative Thereof
5 Oct 23
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing triglycerides in a subject on atorvastatin therapy, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
Rene Braeckman, William Stirtan, Paresh Soni
Filed: 24 Feb 23
Utility
Compositions and Methods for Lowering Triglycerides in a Subject with Reduced Kidney Function and Diabetes Mellitus
10 Aug 23
In various embodiments, the present disclosure provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof having triglyceride levels of about 200 mg/dL to about 499 mg/dL, diabetes mellitus, and reduced kidney function.
Sephy Philip
Filed: 20 Sep 22
Utility
Methods of reducing the risk of cardiovascular events in a subject
8 Aug 23
In various embodiments, the present disclosure provides methods reducing the risk of cardiovascular events in a subject on statin therapy by administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
Paresh Soni
Filed: 18 Dec 20
Utility
Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
1 Aug 23
In various embodiments, the present invention provides pharmaceutical compositions and methods for treating cardiovascular-related disease.
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Jonathan Rowe
Filed: 3 Nov 20
Utility
Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
1 Aug 23
In various embodiments, the present invention provides pharmaceutical compositions and methods for treating cardiovascular-related disease.
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Jonathan Rowe
Filed: 13 Nov 20
Utility
Compositions and Methods for Lowering Triglycerides
6 Jul 23
In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
Filed: 10 Aug 22
Utility
Methods of treating mixed dyslipidemia
4 Jul 23
The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
Filed: 1 Dec 21
Utility
Methods of Reducing the Risk of Cardiovascular Events In a Subject
6 Apr 23
In various embodiments, the present disclosure provides methods reducing the risk of cardiovascular events in a subject on statin therapy by administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
Paresh Soni
Filed: 8 Apr 22
Utility
Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
10 Jan 23
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and a statin and to methods of using the same to treat or prevent cardiovascular-related diseases.
George Grandolfi
Filed: 16 Nov 18
Utility
Low Eructation Composition and Methods for Treating And/or Preventing Cardiovascular Disease In a Subject with Fish Allergy/hypersensitivity
5 Jan 23
In various embodiments, the present invention provides pharmaceutical compositions and methods for treating cardiovascular-related disease.
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Jonathan Rowe
Filed: 18 Feb 22
Utility
Methods of Reducing the Need for Peripheral Arterial Revascularization In a Statin-treated Subject
17 Nov 22
In various embodiments, the present disclosure provides methods of diagnosing a need for peripheral arterial revascularization and/or reducing a need for peripheral arterial revascularization in a subject by administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
Craig Granowitz, Sephy Philip
Filed: 15 Aug 19
Utility
Methods of Reducing the Risk of Heart Failure
3 Nov 22
In various embodiments, the present disclosure provides methods reducing the risk of heart failure in a subject on statin therapy by administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
Paresh Soni
Filed: 19 Apr 22
Utility
Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
13 Oct 22
In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
Filed: 24 Jan 22
Utility
Compositions and Methods for Treating And/or Preventing Cardiovascular Disease
13 Oct 22
In various embodiments, the present invention provides pharmaceutical compositions comprising fatty acids and methods for treating subjects using same.
Jonathan Rowe
Filed: 3 Dec 21
Utility
Compositions and Methods for Lowering Triglycerides Without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
13 Oct 22
In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
Filed: 16 Feb 22
Utility
Methods of Treating Hypertriglyceridemia
13 Oct 22
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
Rene Braeckman, William Stirtan, Paresh Soni
Filed: 17 May 22
Utility
Compositions and methods for lowering triglycerides
11 Oct 22
In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
Filed: 13 Jan 21
Utility
Methods of Treating Hypertriglyceridemia
6 Oct 22
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
Filed: 25 Feb 22