19 patents
Utility
Compounds, Compositions and Methods for Histone Lysine Demethylase Inhibition
4 Jan 24
The present disclosure relates generally to compounds and pharmaceutical compositions for the selective inhibition of histone lysine demethylase5 (KDM5), particularly KDM5B, and methods of their use in treating conditions and diseases associated with KDM5 activity.
Zuhui ZHANG, Xiaoti Zhou, Michael P. Arend, Christian Hauge Kjaergaard
Filed: 27 Aug 21
Utility
Methods for Treatment of Motor Neuron Diseases
19 Jan 23
The invention relates to methods and agents useful for treating motor neuron diseases (MNDs), in particular, amyotrophic lateral sclerosis (ALS).
Enrique BRANDAN, David GONZALEZ
Filed: 7 Mar 22
Utility
Methods of Treatment of Muscular Dystrophies
12 May 22
The invention relates to methods and agents useful for treating muscular dystrophies (MDs), in particular, Duchenne muscular dystrophy (DMD).
Kin-Hung (Peony) YU, Elias KOUCHAKJI, Bassem ELMANKABADI, Tro SEKAYAN
Filed: 19 Jan 22
Utility
Pharmaceutical Formulations of a Hif Hydroxylase Inhibitor
24 Feb 22
The present disclosure relates to pharmaceutical formulations of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid and methods of use thereof.
David Conca, Lee Allen Flippin, Scott David Leigh, Claudia Witschi, Lee Robert Wright
Filed: 10 Mar 21
Utility
Nitrogen-containing heteroaryl compounds and methods of use thereof
25 Jan 22
The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
Michael P. Arend, Lee A. Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric D. Turtle, Xiaohui Du
Filed: 13 Mar 20
Utility
Methods for Treating Anemia In Subjects Having Kidney Failure Using Inhibitors of Hypoxia-inducible Factor (Hif) Hydroxylase
2 Dec 21
The present invention provides methods for treating anemia in a subject having kidney failure by administering a compound that inhibits hypoxia-inducible factor (HIF) prolyl hydroxylase.
Stephen J. KLAUS, Al Y. LIN, Thomas B. NEFF, Qingjian WANG, Volkmar GUENZLER-PUKALL, Lee A. FLIPPIN, Michael P. AREND, Alex MELEKHOV
Filed: 5 Aug 21
Utility
Methods of Treating Acute Respiratory Distress Syndrome
30 Sep 21
The invention relates to methods and agents useful for treating acute respiratory distress syndrome (ARDS).
Elias KOUCHAKJI
Filed: 30 Mar 21
Utility
Connective Tissue Growth Factor Antibodies
29 Jul 21
The present invention relates to antibodies that bind to CTGF.
Al Y. LIN, Thomas B. NEFF, Noelynn A. OLIVER, William R. USINGER, Qingjian WANG, David A. YEOWELL
Filed: 8 Sep 20
Utility
Enhanced Erythropoiesis and Iron Metabolism
22 Apr 21
The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Robert C. Stephenson, Todd W. Seeley, Ingrid Langsetmo Parobok
Filed: 23 Dec 20
Utility
Enhanced erythropoiesis and iron metabolism
23 Feb 21
The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
Stephen J Klaus, Al Y. Lin, Thomas B. Neff, Volkmar Guenzler-Pukall, Qingjian Wang, Lee A. Flippin, Michael P. Arend
Filed: 30 Jan 18
Utility
Enhanced erythropoiesis and iron metabolism
19 Jan 21
The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
Stephen J. Klaus, Christopher J Molineaux, Thomas B Neff, Volkmar Guenzler-Pukall, Robert C. Stephenson, Todd W. Seeley, Ingrid Langsetmo Parobok
Filed: 27 Apr 17
Utility
Enhanced erythropoiesis and iron metabolism
4 Jan 21
The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
Stephen J Klaus, Christopher J Molineaux, Thomas B Neff, Volkmar Guenzler-Pukall, Robert C Stephenson, Todd W Seeley, Ingrid Langsetmo Parobok
Filed: 28 Jan 18
Utility
Methods of Treatment of Muscular Dystrophies
25 Nov 20
The invention relates to methods and agents useful for treating muscular dystrophies (MDs), in particular, Duchenne muscular dystrophy (DMD).
Kin-Hung (Peony) YU, Elias KOUCHAKJI, Bassem ELMANKABADI, Tro SEKAYAN
Filed: 20 May 20
Utility
Pharmaceutical formulations of a HIF hydroxylase inhibitor
7 Sep 20
The present disclosure relates to pharmaceutical formulations of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid and methods of use thereof.
David Conca, Lee Allen Flippin, Scott David Leigh, Claudia Witschi, Lee Robert Wright
Filed: 12 Jul 18
Utility
Nitrogen-containing heteroaryl compounds and methods of use thereof
11 May 20
The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
Michael P. Arend, Lee A. Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric D. Turtle, Xiaohui Du
Filed: 21 Aug 18
Utility
Enhanced erythropoiesis and iron metabolism
20 Apr 20
The present invention relates to methods and compounds for regulating or enhancing ethropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
Stephen J. Klaus, Christopher J Molineaux, Thomas B Neff, Volkmar Guenzler-Pukall, Robert C. Stephenson, Todd W. Seeley, Ingrid Langsetmo Parobok
Filed: 16 Apr 17
Utility
Methods for Treating Idiopathic Pulmonary Fibrosis
15 Apr 20
The present invention relates to methods and medicaments useful for treating idiopathic pulmonary fibrosis (IPF) by administering anti-CTGF antibodies.
Seth PORTER, John L. Stauffer
Filed: 10 Dec 19
Utility
Crystalline Forms of a Prolyl Hydroxylase Inhibitor
15 Apr 20
The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.
Claudia Witschi, Jung Min Park, Michael D. Thompson, Michael John Martinelli, David A. Yeowell, Michael P. Arend
Filed: 15 Dec 19
Utility
Methods for treating idiopathic pulmonary fibrosis
10 Feb 20
The present invention relates to methods and medicaments useful for treating idiopathic pulmonary fibrosis (IPF) by administering anti-CTGF antibodies.
Seth Porter, John L. Stauffer
Filed: 4 Jul 18
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