Vaccine containing cancer cells inactivated by photodynamic treatment with metal-based coordination complexes, and immunotherapy method using same
11 Oct 22
A method for treating a tumor in a patient by administering to the patient an immunogenic composition including antigenic material inactivated by treatment with a metal-based coordination complex and electromagnetic radiation, wherein the immunogenic composition is effective to elicit an immune response to the antigenic material in the patient after administration and the metal-based coordination complex having a specified formula.
Filed: 11 May 18
Sonodynamic Therapy Using Sonodynamically Activated Coordination Complexes of Transition Metals As Sensitizing Agents
22 Sep 22
A method for destroying cells and/or microorganisms in an organism includes the following steps: (a) administering to the organism a composition including a sonosensitizing compound containing at least one transition metal with three bidentate ligands; and (b) exposing the sonosensitizing compound in the organism to ultrasound, wherein the ultrasound is effective to activate the sonosensitizing compound to destroy at least one of the cells and the microorganisms in the organism.
Arkady Mandel, Roger Dumoulin-White
Filed: 4 Mar 21
Inactivation of Pathogens Using Metal-based Coordination Complexes, and Methods and Compositions for Treating and Preventing Microbial And/or Viral Infections
8 Sep 22
A method for eliciting an immune response in a patient includes the sequential steps of: providing an immunogenic composition including an immunogen; adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen; and administering the immunogenic composition to the patient so as to elicit the immune response against the immunogen.
Roger DUMOULIN-WHITE, Arkady MANDEL
Filed: 4 Mar 21
Apparatus and Method for Irradiating Inside an Object
3 Mar 22
An apparatus for irradiating inside an object is disclosed, including a lumen having a longitudinal axis; optical fibers within the lumen and aligned with the longitudinal axis; and an illumination member moveable or fixed within the lumen along the longitudinal axis.
Leonid VESSELOV, Roger J. DUMOULIN-WHITE
Filed: 31 Aug 20
Fiber optic light delivery, monitoring and apparatus therefor
8 Feb 22
Apparatus for illuminating comprises one or more fibers, the one or more fibers including fiber portions meeting at an apex and a bottom location to form a three dimensional cage; a detector attached to each of the fiber portions for receiving light and transmitting light along each of the fiber portions, respectively; and an illumination member situated within the cage.
Lothar Lilge, Arkady Mandel, Wayne Embree, Don Lem, Jenny Wu, Roger Dumoulin-White
Filed: 10 Oct 16
Apparatus and method for multiwavelength photodynamic therapy
6 Jan 20
A method for treating a condition in a tissue, includes the steps: (1) providing a PS within the tissue; (2) irradiating the tissue containing the PS with a first light of a first wavelength; and (3) irradiating the tissue containing the PS with a second light of a second wavelength so as to treat the condition in the tissue, wherein: (a) the PS absorbs light at the first wavelength and the second wavelength; and (b) the second light is more strongly absorbed by the tissue than the first light or vice versa, so as to achieve a predetermined absorbed photon density gradient.
Arkady Mandel, Roger Dumoulin-White, Wayne Embree
Filed: 28 Apr 15
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