747 patents
Utility
Therapeutic DNP Derivatives and Methods Using Same
18 Jan 24
The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof.
Gerald I. Shulman, David A. Spiegel
Filed: 11 Jan 23
Utility
a Gene Associated with Human Reading Performance
18 Jan 24
Disclosed herein are kits and methods for assessing the risk of poor reading performance in an individual by detecting and identifying single nucleotide polymorphisms in chromosome 19, e.g. in the KIAA0355 (GARRE1) gene.
Jeffrey R. Gruen, Andrew Adams, Dongnhu Truong, Jan Frijters, Joan Bosson-Heenan
Filed: 8 Oct 20
Utility
Compositions and Methods for Inhibiting Group II Intron Rna
18 Jan 24
The present invention provides compositions and methods for inhibiting group II intron splicing for treating or preventing a disease or disorder associated with an organism harboring an active group II intron.
Anna Marie Pyle, Olga Fedorova, Erik Jagdmann, Michael Van Zandt, Lin Yuan, Albert DeBerardinis
Filed: 28 Aug 23
Utility
Method of Manipulating Pluripotency In Cells
18 Jan 24
Described herein is a method of maintaining pluripotency in a cell.
Valentyna Kostiuk, Mustafa Khokha
Filed: 12 Jul 23
Utility
Compositions and methods for delivery of nucleic acids to cells
16 Jan 24
Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided.
Elias Quijano, Peter Glazer
Filed: 30 Aug 22
Utility
N-Linked Glycosylation Inhibitors and Methods of Using Same
11 Jan 24
The present disclosure includes compounds, compositions, and methods for preventing, ameliorating, and/or treating diseases associated with N-linked glycosylation and/or oligosaccharyltransferase function in a subject in need thereof.
Joseph N. Contessa, Michael Van Zandt
Filed: 31 Aug 21
Utility
Flow sensor for cerebral fluidic device
9 Jan 24
The present disclosure provides a fluidic device including (a) a first channel including a first inlet and a first outlet, (b) a second channel including a second inlet and a second outlet, wherein the second inlet of the second channel is in fluid communication with the first outlet of the first channel, and (c) a sensor positioned between the first outlet and the second inlet, wherein the sensor includes a sensor configured to deflect in response to a flow between the first channel and the second channel.
Kazunori Hoshino, Davina Jaiswal, Mengdi Bao, Garrett Soler, Ariane Garrett, Ryan Grant, Michael Diluna, Hitten Zaveri
Filed: 29 Mar 18
Utility
Peptidic materials that traffic efficiently to the cell cytosol and nucleus
9 Jan 24
This invention is generally related to modified peptidic oligomers that have an increased ability to reach the cytosol or nucleus.
Alanna Schepartz Shrader, Kim Quach
Filed: 2 Nov 18
Utility
Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
9 Jan 24
The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety.
Albert J. Sinusas, Joseph G. Akar, Richard R. Cesati, Heike S. Radeke, Stephen B. Haber
Filed: 22 May 20
Utility
Patient-controlled liquid oral medicine dispenser and deactivation system
2 Jan 24
Provided herein are patient-controlled oral liquid-medicine dispenser and deactivation systems.
Daniel Wiznia, Jinlei Li, Claudia See
Filed: 2 Jun 23
Utility
Liposome compositions and methods of use thereof
2 Jan 24
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
Filed: 17 Dec 19
Utility
Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
2 Jan 24
The present invention is directed to new bifunctional compounds and methods for treating HIV infections.
David Spiegel, Christopher Parker
Filed: 9 Sep 21
Utility
Compositions and Methods for Treating, Ameliorating, And/or Preventing Diseases or Disorders Caused by or Associated with DNASE1 And/or DNASE1L3 Deficiency
28 Dec 23
The present disclosure includes novel DNAse1 and/or DNAse1L3 constructs with improved in vivo half-lives, enzymatic stability, and/or developability properties.
Paul Stabach, Demetrios Braddock
Filed: 18 Jul 23
Utility
Nanobody Compositions and Methods of Use of the Same
28 Dec 23
The invention provides methods for identifying nanobodies that bind with high affinity to secreted proteins or extracellular proteins, as well and compositions comprising the identified nanobodies and methods of use thereof.
Aaron Ring, Feimei Liu
Filed: 20 Aug 21
Utility
Binding Proteins 1
21 Dec 23
The present disclosure relates to cell penetrating anti-DNA binding proteins.
James CAMPBELL, Valentina DUBLJEVIC, James HANSEN, Zahra RATTRAY, Jiangbing ZHOU
Filed: 3 Feb 23
Utility
Targeting Host-bacteria Interactions for the Treatment of Microbiota-mediated Diseases
21 Dec 23
The present invention generally relates to compositions and methods for modulating specific paired host protein-microbiota interactions and the use thereof for the prevention and treatment of diseases and disorders.
Connor Rosen, Noah Palm, Aaron Ring
Filed: 17 Nov 21
Utility
Patient-controlled Liquid Oral Medicine Dispenser and Deactivation System
14 Dec 23
Provided herein are patient-controlled oral liquid-medicine dispenser and deactivation systems.
Daniel Wiznia, Jinlei Li, Claudia See
Filed: 2 Jun 23
Utility
Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same
14 Dec 23
The present disclosure provides inhibitors of MIF tautomerase activity.
William L. Jorgensen
Filed: 26 Oct 21
Utility
Inhibition of androgen receptor by extracts of medicinal herbs and compositions thereof
12 Dec 23
In one embodiment, the present invention is directed to a composition comprising an aqueous or ethanolic extract of at least one herb selected from the group consisting of Aloe barbadensis (:F3), Rheum palmatum L. (:B6), Stephania tetrandra (:C4), Phellodendron chinense Schneid. (:D8), Euphorbia humifusa (:S6), Eclipta prostrata (:I2), A. venetum L. (:F1), Portulaca oleracea L. (:F5), and Sanguisorba officinalis L. (:E5), Camellia sinensis var. assamica (Mast.) Kitamura (:PE) and Punica granatum. (:PG), and mixtures thereof.
Yung-Chi Cheng, Wing Lam, Zaoli Jiang
Filed: 18 Oct 18
Utility
Methods and tools for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject
12 Dec 23
The present tools and methods for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject.
John D. Murray, Alan Anticevic, William J. Martin
Filed: 3 Feb 21