Michael Landsittel

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
15 Aug 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	95.23	4,409	419.87 k	67,208
15 May 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	106.56	1,364	145.35 k	71,617
15 May 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	107.17	2,486	266.42 k	72,981
8 May 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	No	8.8	1,818	16.00 k	75,467
8 May 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	No	1.87	26,363	49.30 k	73,649
8 May 24	BPMC Blueprint Medicines	Stock Option Common Stock	Option exercise	Acquire M	No	No	8.8	1,818	16.00 k	0
8 May 24	BPMC Blueprint Medicines	Stock Option Common Stock	Option exercise	Acquire M	No	No	1.87	26,363	49.30 k	0
2 May 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	105	10,000	1.05 mm	47,286
2 May 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	Yes	36.05	10,000	360.50 k	57,286
2 May 24	BPMC Blueprint Medicines	Stock Option Common Stock	Option exercise	Dispose M	No	Yes	36.05	10,000	360.50 k	0

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.