Eugene Schneider

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
31 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.1967	1,484	47.78 k	61,056
30 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	4,032	0.00	62,540
16 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.79	6,523	213.89 k	58,508
15 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	17,372	0.00	65,031
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	17,372	0.00	60,936
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	33,000	0.00	78,308
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	22,000	0.00	65,437
2 Jan 25	IONS Ionis Pharmaceuticals	NQSO Common Stock	Grant	Acquire A	No	No	34.69	22,000	763.18 k	22,000
2 Feb 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	49.59	2,106	104.44 k	47,659
2 Feb 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	49.59	2,071	102.70 k	49,812

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.