L. Becker Hewes

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
4 Jun 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	104.91	2,424	254.30 k	29,514
3 Jun 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	No	106.43	1,951	207.64 k	31,938
3 Jun 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	106.43	2,971	316.20 k	33,889
31 May 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	104.83	6,342	664.83 k	36,860
31 May 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	105.81	20,904	2.21 mm	43,202
31 May 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	106.5	3,191	339.84 k	64,106
31 May 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	107.86	3,671	395.95 k	67,297
31 May 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	Yes	43.15	5,729	247.21 k	70,968
31 May 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	Yes	61.31	8,385	514.08 k	65,239
31 May 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	Yes	66.24	10,573	700.36 k	56,854

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.