Kristen Ambrose

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
18 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	455.06	671	305.35 k	10,798
14 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	463.46	564	261.39 k	11,469
12 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	2,080	0.00	12,033
11 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	459.83	1,376	632.73 k	9,953
10 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	467.98	591	276.58 k	11,329
4 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	1,854	0.00	11,920
4 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	2,566	0.00	10,066
2 Apr 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	419	240	100.56 k	7,500
1 Apr 24	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	418.1	225	94.07 k	7,740

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.