COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 3,887,654 | 270,728 | SH | | DFND | 2 | 270,728 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 174,018,604 | 1,538,490 | SH | | DFND | 2 | 1,538,490 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 16,985,729 | 150,170 | SH | | DFND | 3 | 150,170 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 8,042,524 | 45,259 | SH | | DFND | 2 | 45,259 | 0 | 0 |
ACCOLADE INC | COM | 00437E102 | 2,105,041 | 615,509 | SH | | DFND | 2 | 615,509 | 0 | 0 |
ADMA BIOLOGICS INC | COM | 000899104 | 289,835 | 16,900 | SH | | DFND | 2 | 16,900 | 0 | 0 |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 108,278 | 806 | SH | | DFND | 2 | 806 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 115,507,829 | 3,515,150 | SH | | DFND | 1,2 | 3,515,150 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 33,362,226 | 160,003 | SH | | DFND | 2 | 160,003 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 2,416,163 | 10,268 | SH | | DFND | 2 | 10,268 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 178,835,600 | 760,000 | SH | | DFND | 1,2 | 760,000 | 0 | 0 |
ALPHABET INC | CAP STK CL C | 02079K107 | 1,142,640 | 6,000 | SH | | DFND | 2 | 6,000 | 0 | 0 |
ALTIMMUNE INC | COM NEW | 02155H200 | 6,816,666 | 945,446 | SH | | DFND | 3 | 945,446 | 0 | 0 |
AMGEN INC | COM | 031162100 | 23,259,514 | 89,240 | SH | | DFND | 2 | 89,240 | 0 | 0 |
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 795,279 | 100,414 | SH | | DFND | 2 | 100,414 | 0 | 0 |
ANNEXON INC | COM | 03589W102 | 26,456,898 | 5,157,290 | SH | | DFND | 1,2 | 5,157,290 | 0 | 0 |
ARCELLX INC | COMMON STOCK | 03940C100 | 230,070 | 3,000 | SH | | DFND | 2 | 3,000 | 0 | 0 |
ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 550,235 | 39,500 | SH | | DFND | 2 | 39,500 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 1,343,160 | 2,184 | SH | | DFND | 2 | 2,184 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 363,465,000 | 591,000 | SH | | DFND | 1,2 | 591,000 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 184,032 | 9,600 | SH | | DFND | 2 | 9,600 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 45,624,600 | 2,380,000 | SH | | DFND | 1,2 | 2,380,000 | 0 | 0 |
ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 344,175 | 2,500 | SH | | DFND | 2 | 2,500 | 0 | 0 |
ASTRANA HEALTH INC | COM NEW | 03763A207 | 6,471,186 | 205,239 | SH | | DFND | 3 | 205,239 | 0 | 0 |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 2,339,064 | 35,700 | SH | | DFND | 2 | 35,700 | 0 | 0 |
AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 97,525 | 41,500 | SH | | DFND | 2 | 41,500 | 0 | 0 |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 372,284 | 4,400 | SH | | DFND | 2 | 4,400 | 0 | 0 |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 9,690,383 | 114,530 | SH | | DFND | 3 | 114,530 | 0 | 0 |
BAIDU INC | SPON ADR REP A | 056752108 | 168,620 | 2,000 | SH | | DFND | 2 | 2,000 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 37,649,401 | 1,518,121 | SH | | DFND | 1,2 | 1,518,121 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 76,579,515 | 337,548 | SH | | DFND | 2 | 337,548 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 6,322,439 | 34,229 | SH | | DFND | 2 | 34,229 | 0 | 0 |
BIO RAD LABS INC | CL A | 090572207 | 11,021,839 | 33,551 | SH | | DFND | 3 | 33,551 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 405,544 | 2,652 | SH | | DFND | 2 | 2,652 | 0 | 0 |
BIOHAVEN LTD | COM | G1110E107 | 76,225,860 | 2,040,853 | SH | | DFND | 1,2 | 2,040,853 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 243,201 | 3,700 | SH | | DFND | 2 | 3,700 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 21,383,349 | 325,321 | SH | | DFND | 3 | 325,321 | 0 | 0 |
BIONTECH SE | SPONSORED ADS | 09075V102 | 949,431 | 8,332 | SH | | DFND | 2 | 8,332 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 18,228,175 | 8,517,839 | SH | | DFND | 1,2 | 8,517,839 | 0 | 0 |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 279,104 | 3,200 | SH | | DFND | 2 | 3,200 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 190,724,549 | 2,135,295 | SH | | DFND | 2 | 2,135,295 | 0 | 0 |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 285,376 | 10,400 | SH | | DFND | 2 | 10,400 | 0 | 0 |
BRIGHTSPRING HEALTH SVCS INC | COM | 10950A106 | 2,965,809 | 174,152 | SH | | DFND | 3 | 174,152 | 0 | 0 |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 2,155,671 | 38,113 | SH | | DFND | 2 | 38,113 | 0 | 0 |
BRUKER CORP | COM | 116794108 | 21,079,049 | 359,588 | SH | | DFND | 2 | 359,588 | 0 | 0 |
CARDINAL HEALTH INC | COM | 14149Y108 | 2,637,184 | 22,298 | SH | | DFND | 2 | 22,298 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 29,426,161 | 1,374,412 | SH | | DFND | 3 | 1,374,412 | 0 | 0 |
CASTLE BIOSCIENCES INC | COM | 14843C105 | 19,880,420 | 745,982 | SH | | DFND | 3 | 745,982 | 0 | 0 |
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 77,619,711 | 3,071,615 | SH | | DFND | 1,2 | 3,071,615 | 0 | 0 |
CENCORA INC | COM | 03073E105 | 17,417,643 | 77,522 | SH | | DFND | 2 | 77,522 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 5,237,504 | 86,456 | SH | | DFND | 2 | 86,456 | 0 | 0 |
CERTARA INC | COM | 15687V109 | 981,174 | 92,129 | SH | | DFND | 2 | 92,129 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 9,290,364 | 50,327 | SH | | DFND | 3 | 50,327 | 0 | 0 |
COOPER COS INC | COM | 216648501 | 32,830,961 | 357,130 | SH | | DFND | 2 | 357,130 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 980,577 | 21,844 | SH | | DFND | 2 | 21,844 | 0 | 0 |
CYTOKINETICS INC | COM NEW | 23282W605 | 514,665 | 10,941 | SH | | DFND | 2 | 10,941 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 18,650,478 | 81,248 | SH | | DFND | 2 | 81,248 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 8,877,617 | 38,674 | SH | | DFND | 3 | 38,674 | 0 | 0 |
DENALI THERAPEUTICS INC | COM | 24823R105 | 319,966 | 15,700 | SH | | DFND | 2 | 15,700 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 69,099,267 | 888,508 | SH | | DFND | 2 | 888,508 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 12,173,805 | 156,536 | SH | | DFND | 3 | 156,536 | 0 | 0 |
DOXIMITY INC | CL A | 26622P107 | 1,490,168 | 27,911 | SH | | DFND | 2 | 27,911 | 0 | 0 |
DR REDDYS LABS LTD | ADR | 256135203 | 1,545,841 | 97,900 | SH | | DFND | 2 | 97,900 | 0 | 0 |
EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 38,152,404 | 1,428,929 | SH | | DFND | 1,2 | 1,428,929 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 62,708,148 | 847,064 | SH | | DFND | 2 | 847,064 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 18,565,540 | 250,784 | SH | | DFND | 3 | 250,784 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 14,144,733 | 38,343 | SH | | DFND | 2 | 38,343 | 0 | 0 |
ELI LILLY & CO | COM | 532457108 | 35,098,980 | 45,465 | SH | | DFND | 2 | 45,465 | 0 | 0 |
ENCOMPASS HEALTH CORP | COM | 29261A100 | 17,410,007 | 188,522 | SH | | DFND | 2 | 188,522 | 0 | 0 |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 21,876,941 | 9,944,064 | SH | | DFND | 1,2 | 9,944,064 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 3,009,128 | 267,478 | SH | | DFND | 2 | 267,478 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 9,519,525 | 846,180 | SH | | DFND | 3 | 846,180 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 16,095,794 | 286,453 | SH | | DFND | 2 | 286,453 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 22,903,213 | 407,603 | SH | | DFND | 3 | 407,603 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 7,985,635 | 4,839,779 | SH | | DFND | 1,2 | 4,839,779 | 0 | 0 |
GARMIN LTD | SHS | H2906T109 | 216,573 | 1,050 | SH | | DFND | 2 | 1,050 | 0 | 0 |
GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 | 40,998,687 | 524,414 | SH | | DFND | 2 | 524,414 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 4,473,387 | 48,429 | SH | | DFND | 2 | 48,429 | 0 | 0 |
GLAUKOS CORP | COM | 377322102 | 9,127,598 | 60,875 | SH | | DFND | 2 | 60,875 | 0 | 0 |
GLOBUS MED INC | CL A | 379577208 | 30,021,993 | 362,979 | SH | | DFND | 2 | 362,979 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 18,574,182 | 61,883 | SH | | DFND | 2 | 61,883 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 17,870,102 | 247,886 | SH | | DFND | 2 | 247,886 | 0 | 0 |
HUMANA INC | COM | 444859102 | 7,196,992 | 28,367 | SH | | DFND | 2 | 28,367 | 0 | 0 |
IDEXX LABS INC | COM | 45168D104 | 31,808,006 | 76,935 | SH | | DFND | 2 | 76,935 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 5,840,032 | 43,703 | SH | | DFND | 2 | 43,703 | 0 | 0 |
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 35,561,188 | 1,205,464 | SH | | DFND | 1,2 | 1,205,464 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 516,505 | 7,478 | SH | | DFND | 2 | 7,478 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 148,500,500 | 2,150,000 | SH | | DFND | 1,2 | 2,150,000 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 559,224 | 8,100 | SH | | DFND | 2 | 8,100 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 17,286,442 | 250,383 | SH | | DFND | 3 | 250,383 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 6,005,756 | 32,397 | SH | | DFND | 2 | 32,397 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 21,519,096 | 116,081 | SH | | DFND | 3 | 116,081 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 71,280,725 | 273,033 | SH | | DFND | 2 | 273,033 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 12,762,146 | 48,884 | SH | | DFND | 3 | 48,884 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 1,272,845 | 15,240 | SH | | DFND | 2 | 15,240 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 202,536,000 | 2,425,000 | SH | | DFND | 1,2 | 2,425,000 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 218,660,527 | 418,922 | SH | | DFND | 2 | 418,922 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 23,725,692 | 45,455 | SH | | DFND | 3 | 45,455 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 653,752 | 18,700 | SH | | DFND | 2 | 18,700 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 274,436,000 | 7,850,000 | SH | | DFND | 1,2 | 7,850,000 | 0 | 0 |
IQVIA HLDGS INC | COM | 46266C105 | 68,385 | 348 | SH | | DFND | 2 | 348 | 0 | 0 |
IQVIA HLDGS INC | COM | 46266C105 | 8,741,747 | 44,485 | SH | | DFND | 3 | 44,485 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 7,890,033 | 54,557 | SH | | DFND | 2 | 54,557 | 0 | 0 |
KINIKSA PHARMACEUTICALS INTL | ORD SHS CL A | G52694109 | 160,218 | 8,100 | SH | | DFND | 2 | 8,100 | 0 | 0 |
KRYSTAL BIOTECH INC | COM | 501147102 | 790,663 | 5,047 | SH | | DFND | 2 | 5,047 | 0 | 0 |
KURA ONCOLOGY INC | COM | 50127T109 | 118,456 | 13,600 | SH | | DFND | 2 | 13,600 | 0 | 0 |
LABCORP HOLDINGS INC | COM SHS | 504922105 | 49,533 | 216 | SH | | DFND | 2 | 216 | 0 | 0 |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 5,445,276 | 167,341 | SH | | DFND | 2 | 167,341 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 32,272,380 | 9,929,963 | SH | | DFND | 1,2 | 9,929,963 | 0 | 0 |
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 339,427 | 1,100 | SH | | DFND | 2 | 1,100 | 0 | 0 |
MASIMO CORP | COM | 574795100 | 3,994,640 | 24,166 | SH | | DFND | 2 | 24,166 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 3,430,858 | 6,020 | SH | | DFND | 2 | 6,020 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 7,576,953 | 13,295 | SH | | DFND | 3 | 13,295 | 0 | 0 |
MEDTRONIC PLC | SHS | G5960L103 | 83,310,686 | 1,042,948 | SH | | DFND | 2 | 1,042,948 | 0 | 0 |
MERCK & CO INC | COM | 58933Y105 | 26,285,202 | 264,226 | SH | | DFND | 2 | 264,226 | 0 | 0 |
MERUS N V | COM | N5749R100 | 336,400 | 8,000 | SH | | DFND | 2 | 8,000 | 0 | 0 |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 51,395 | 42 | SH | | DFND | 2 | 42 | 0 | 0 |
MICROSOFT CORP | COM | 594918104 | 85,565 | 203 | SH | | DFND | 2 | 203 | 0 | 0 |
MINERALYS THERAPEUTICS INC | COM | 603170101 | 203,103 | 16,499 | SH | | DFND | 2 | 16,499 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 36,466 | 877 | SH | | DFND | 2 | 877 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 66,528,000 | 1,600,000 | SH | | DFND | 1,2 | 1,600,000 | 0 | 0 |
MODERNA INC | CALL | 60770K907 | 109,973 | 150 | SH | Call | DFND | 2 | 150 | 0 | 0 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 23,910,049 | 82,151 | SH | | DFND | 2 | 82,151 | 0 | 0 |
MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 238,260 | 4,400 | SH | | DFND | 2 | 4,400 | 0 | 0 |
NATERA INC | COM | 632307104 | 14,781,421 | 93,376 | SH | | DFND | 2 | 93,376 | 0 | 0 |
NATERA INC | COM | 632307104 | 8,279,090 | 52,300 | SH | | DFND | 3 | 52,300 | 0 | 0 |
NEOGENOMICS INC | COM NEW | 64049M209 | 17,399,518 | 1,055,796 | SH | | DFND | 3 | 1,055,796 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 248,430,000 | 1,820,000 | SH | | DFND | 1,2 | 1,820,000 | 0 | 0 |
NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 642,500 | 25,000 | SH | | DFND | 2 | 25,000 | 0 | 0 |
NURIX THERAPEUTICS INC | COM | 67080M103 | 150,720 | 8,000 | SH | | DFND | 2 | 8,000 | 0 | 0 |
NVIDIA CORPORATION | COM | 67066G104 | 100,852 | 751 | SH | | DFND | 2 | 751 | 0 | 0 |
OCULIS HOLDING AG | ORDINARY SHARES | H5870P102 | 170,000 | 10,000 | SH | | DFND | 2 | 10,000 | 0 | 0 |
OMNICELL COM | COM | 68213N109 | 4,217,825 | 94,740 | SH | | DFND | 2 | 94,740 | 0 | 0 |
ORACLE CORP | COM | 68389X105 | 108,983 | 654 | SH | | DFND | 2 | 654 | 0 | 0 |
PENUMBRA INC | COM | 70975L107 | 56,532,826 | 238,053 | SH | | DFND | 2 | 238,053 | 0 | 0 |
PFIZER INC | COM | 717081103 | 3,755,587 | 141,560 | SH | | DFND | 2 | 141,560 | 0 | 0 |
PHREESIA INC | COM | 71944F106 | 10,207,236 | 405,693 | SH | | DFND | 2 | 405,693 | 0 | 0 |
PRIVIA HEALTH GROUP INC | COM | 74276R102 | 18,634,356 | 953,164 | SH | | DFND | 2 | 953,164 | 0 | 0 |
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 37,272,225 | 462,894 | SH | | DFND | 2 | 462,894 | 0 | 0 |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 915,515 | 23,718 | SH | | DFND | 2 | 23,718 | 0 | 0 |
PTC THERAPEUTICS INC | COM | 69366J200 | 171,532 | 3,800 | SH | | DFND | 2 | 3,800 | 0 | 0 |
QUALCOMM INC | COM | 747525103 | 68,668 | 447 | SH | | DFND | 2 | 447 | 0 | 0 |
RECURSION PHARMACEUTICALS IN | CL A | 75629V104 | 2,553,969 | 377,806 | SH | | DFND | 2 | 377,806 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 22,375,710 | 31,412 | SH | | DFND | 2 | 31,412 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 9,443 | 2,292 | SH | | DFND | 2 | 2,292 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 30,385,000 | 7,375,000 | SH | | DFND | 1,2 | 7,375,000 | 0 | 0 |
RESMED INC | COM | 761152107 | 36,771,751 | 160,793 | SH | | DFND | 2 | 160,793 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 551,124 | 12,600 | SH | | DFND | 2 | 12,600 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 191,331,882 | 4,374,300 | SH | | DFND | 1,2 | 4,374,300 | 0 | 0 |
RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 1,320,904 | 23,596 | SH | | DFND | 2 | 23,596 | 0 | 0 |
ROIVANT SCIENCES LTD | SHS | G76279101 | 283,920 | 24,000 | SH | | DFND | 2 | 24,000 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 24,221,563 | 4,460,693 | SH | | DFND | 1,2 | 4,460,693 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 182,385 | 1,500 | SH | | DFND | 2 | 1,500 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 20,648,049 | 169,817 | SH | | DFND | 3 | 169,817 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 1,036,545 | 23,983 | SH | | DFND | 2 | 23,983 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 107,475,477 | 2,486,707 | SH | | DFND | 1,2 | 2,486,707 | 0 | 0 |
SI-BONE INC | COM | 825704109 | 12,351,326 | 880,979 | SH | | DFND | 3 | 880,979 | 0 | 0 |
SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 3,317,213 | 5,660 | SH | | DFND | 2 | 5,660 | 0 | 0 |
STERIS PLC | SHS USD | G8473T100 | 22,588,372 | 109,887 | SH | | DFND | 2 | 109,887 | 0 | 0 |
STRUCTURE THERAPEUTICS INC | SPONSORD ADS | 86366E106 | 426,706 | 15,734 | SH | | DFND | 2 | 15,734 | 0 | 0 |
STRUCTURE THERAPEUTICS INC | SPONSORD ADS | 86366E106 | 12,727,850 | 469,316 | SH | | DFND | 3 | 469,316 | 0 | 0 |
STRYKER CORPORATION | COM | 863667101 | 187,235,361 | 520,026 | SH | | DFND | 2 | 520,026 | 0 | 0 |
SUMMIT THERAPEUTICS INC | COM | 86627T108 | 3,044,250 | 170,594 | SH | | DFND | 2 | 170,594 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 79,244 | 2,200 | SH | | DFND | 2 | 2,200 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 28,104,821 | 780,256 | SH | | DFND | 3 | 780,256 | 0 | 0 |
TEMPUS AI INC | CL A | 88023B103 | 8,001 | 237 | SH | | DFND | 2 | 237 | 0 | 0 |
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 13,914,333 | 110,230 | SH | | DFND | 2 | 110,230 | 0 | 0 |
TERNS PHARMACEUTICALS INC | COM | 880881107 | 5,882,112 | 1,061,753 | SH | | DFND | 3 | 1,061,753 | 0 | 0 |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 1,335,580 | 60,598 | SH | | DFND | 2 | 60,598 | 0 | 0 |
THE CIGNA GROUP | COM | 125523100 | 34,574,109 | 125,205 | SH | | DFND | 2 | 125,205 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 22,619,080 | 43,479 | SH | | DFND | 2 | 43,479 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 9,095,181 | 17,483 | SH | | DFND | 3 | 17,483 | 0 | 0 |
TRANSMEDICS GROUP INC | COM | 89377M109 | 12,015,967 | 192,718 | SH | | DFND | 2 | 192,718 | 0 | 0 |
TRAVERE THERAPEUTICS INC | COM | 89422G107 | 402,402 | 23,100 | SH | | DFND | 2 | 23,100 | 0 | 0 |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 168,280 | 4,000 | SH | | DFND | 2 | 4,000 | 0 | 0 |
UNIQURE NV | SHS | N90064101 | 397,350 | 22,500 | SH | | DFND | 2 | 22,500 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 61,566,703 | 121,707 | SH | | DFND | 2 | 121,707 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 19,225,715 | 38,006 | SH | | DFND | 3 | 38,006 | 0 | 0 |
VANECK ETF TRUST | GOLD MINERS ETF | 92189F106 | 888,442 | 26,200 | SH | | DFND | 2 | 26,200 | 0 | 0 |
VAXCYTE INC | COM | 92243G108 | 985,431 | 12,038 | SH | | DFND | 2 | 12,038 | 0 | 0 |
VEEVA SYS INC | CL A COM | 922475108 | 26,822,644 | 127,575 | SH | | DFND | 2 | 127,575 | 0 | 0 |
VERACYTE INC | COM | 92337F107 | 142,560 | 3,600 | SH | | DFND | 2 | 3,600 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 738,396 | 15,900 | SH | | DFND | 2 | 15,900 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 25,683,874 | 553,055 | SH | | DFND | 3 | 553,055 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 5,007,172 | 12,434 | SH | | DFND | 2 | 12,434 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 191,282,500 | 475,000 | SH | | DFND | 1,2 | 475,000 | 0 | 0 |
VIKING THERAPEUTICS INC | COM | 92686J106 | 520,665 | 12,939 | SH | | DFND | 2 | 12,939 | 0 | 0 |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 50,648,445 | 4,094,458 | SH | | DFND | 1,2 | 4,094,458 | 0 | 0 |
WAYSTAR HLDG CORP | COM | 946784105 | 5,794,857 | 157,898 | SH | | DFND | 2 | 157,898 | 0 | 0 |
XENON PHARMACEUTICALS INC | COM | 98420N105 | 321,440 | 8,200 | SH | | DFND | 2 | 8,200 | 0 | 0 |
ZAI LAB LTD | ADR | 98887Q104 | 340,470 | 13,000 | SH | | DFND | 2 | 13,000 | 0 | 0 |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 31,015,186 | 293,621 | SH | | DFND | 2 | 293,621 | 0 | 0 |
ZOETIS INC | CL A | 98978V103 | 1,593,292 | 9,779 | SH | | DFND | 2 | 9,779 | 0 | 0 |