Elizabeth L Hougen

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
31 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.4384	1,523	49.40 k	110,500
30 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	4,138	0.00	112,023
16 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.806	8,870	290.99 k	107,885
15 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	23,887	0.00	116,755
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	23,887	0.00	84,669
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	46,500	0.00	108,556
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	31,000	0.00	86,635
2 Jan 25	IONS Ionis Pharmaceuticals	NQSO Common Stock	Grant	Acquire A	No	No	34.69	31,000	1.08 mm	31,000
2 Feb 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	49.5399	2,162	107.11 k	92,868

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.