Berthelsen Spencer R

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
15 Jul 24	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	4,677	0.00	151,934
15 Jul 24	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	4,677	0.00	4,079
1 Jul 24	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	4,079	0.00	8,756
1 Jul 24	IONS Ionis Pharmaceuticals	NQSO Common Stock	Grant	Acquire A	No	No	47.11	10,111	476.33 k	10,111
17 Jun 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	40.29	16,000	644.64 k	147,257
17 Jun 24	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	35.53	16,000	568.48 k	163,257
17 Jun 24	IONS Ionis Pharmaceuticals	NQSO Common Stock	Option exercise	Dispose M	No	No	35.53	16,000	568.48 k	0

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.