Sachs Bruce I

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
15 Jan 25	VRTX Vertex Pharmaceuticals	Deferred Stock Units Common Stock	Grant	Acquire A	No	No	420.31	111.654	46.93 k	15,144.986
15 Oct 24	VRTX Vertex Pharmaceuticals	Deferred Stock Units Common Stock	Grant	Acquire A	No	No	484.39	90.32	43.75 k	15,033.332
1 Aug 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	508	5,295	2.69 mm	40,000
1 Aug 24	VRTX Vertex Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	125.71	5,295	665.63 k	45,295
1 Aug 24	VRTX Vertex Pharmaceuticals	Stock Option Common Stock	Option exercise	Dispose M	No	No	125.71	5,295	665.63 k	0
15 Jul 24	VRTX Vertex Pharmaceuticals	Deferred Stock Units Common Stock	Grant	Acquire A	No	No	490.12	89.264	43.75 k	14,943.012
22 May 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	448	7,073	3.17 mm	40,000
22 May 24	VRTX Vertex Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	93.51	7,073	661.40 k	47,073
22 May 24	VRTX Vertex Pharmaceuticals	Stock Option Common Stock	Option exercise	Dispose M	No	No	93.51	7,073	661.40 k	0

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.