Sachs Bruce I

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
15 Oct 25	VRTX Vertex Pharmaceuticals	Deferred Stock Units Common Stock	Grant	Acquire A	No	No	410.31	115.766	47.50 k	15,457.433
6 Aug 25	VRTX Vertex Pharmaceuticals	Common Stock	Buy	Acquire P	No	No	389.84	3,366	1.31 mm	45,000
6 Aug 25	VRTX Vertex Pharmaceuticals	Common Stock	Buy	Acquire P	No	No	389.36	1,634	636.21 k	41,634
15 Jul 25	VRTX Vertex Pharmaceuticals	Deferred Stock Units Common Stock	Grant	Acquire A	No	No	469.34	101.206	47.50 k	15,341.667
1 May 25	VRTX Vertex Pharmaceuticals	Stock Option Common Stock	Grant	Acquire A	No	No	502.97	2,398	1.21 mm	2,398
15 Apr 25	VRTX Vertex Pharmaceuticals	Deferred Stock Units Common Stock	Grant	Acquire A	No	No	497.51	95.475	47.50 k	15,240.461

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.