Klein Joseph Iii

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
16 Jul 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	Yes	Yes	50	12,000	600.00 k	0
16 Jul 24	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	Yes	No	24.42	12,000	293.04 k	12,000
16 Jul 24	IONS Ionis Pharmaceuticals	NQSO Common Stock	Option exercise	Dispose M	Yes	No	24.42	12,000	293.04 k	0
1 Jul 24	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	4,079	0.00	8,756
1 Jul 24	IONS Ionis Pharmaceuticals	NQSO Common Stock	Grant	Acquire A	No	No	47.11	10,111	476.33 k	10,111
3 May 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	Yes	No	42.8957	930	39.89 k	0
3 May 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	Yes	No	42.5473	1,070	45.53 k	930
3 May 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	Yes	No	42.9767	731	31.42 k	2,000
3 May 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	Yes	No	42.5875	1,269	54.04 k	2,731
3 May 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	Yes	No	42.9449	682	29.29 k	4,000

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.