James M Frates

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
3 Jan 25	SAGE Sage Therapeutics	Stock Options Common Stock	Grant	Acquire A	No	No	6.14	19,154	117.61 k	19,154
12 Sep 24	AMLX Amylyx Pharmaceuticals	Common Stock	Buy	Acquire P	No	No	2.5342	40,000	101.37 k	233,464
10 Jun 24	SAGE Sage Therapeutics	Stock Option Common Stock	Grant	Acquire A	No	No	10.9	12,500	136.25 k	12,500
16 Apr 24	AMLX Amylyx Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	91,180	0.00	225,964
16 Apr 24	AMLX Amylyx Pharmaceuticals	Stock Option Common Stock	Grant	Acquire A	No	No	2.01	120,000	241.20 k	120,000
5 Mar 24	AMLX Amylyx Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	18.7279	1,792	33.56 k	134,784

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.