Leiden Jeffrey M

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
30 Aug 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	499	3,784	1.89 mm	9,994
20 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	420.58	4,118	1.73 mm	13,778
15 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	419.16	4,655	1.95 mm	17,896
14 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	419.04	4,356	1.83 mm	22,551
13 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	419.13	737	308.90 k	26,907
12 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	420.39	647	271.99 k	27,644
12 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	419.22	2,009	842.21 k	28,291
9 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	422.74	8,048	3.40 mm	30,300
8 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	421.73	2,698	1.14 mm	38,348

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.