Brett P Monia

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
4 Feb 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	31.6521	38,843	1.23 mm	180,683
31 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.4464	13,242	429.66 k	219,526
30 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	25,372	0.00	232,768
16 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.634	33,445	1.09 mm	207,396
15 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	73,448	0.00	240,841
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	73,448	0.00	252,159
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	129,395	0.00	325,607
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	169,950	0.00	630,201
2 Jan 25	IONS Ionis Pharmaceuticals	NQSO Common Stock	Grant	Acquire A	No	No	34.69	86,263	2.99 mm	86,263
12 Nov 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	38.0534	6,630	252.29 k	167,393

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.