Arbuckle Stuart A

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
21 Jun 24	RYTM Rhythm Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	3,000	0.00	3,000
21 Jun 24	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	3,000	0.00	0
18 Jun 24	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	4,000	0.00	4,000
18 Jun 24	RYTM Rhythm Pharmaceuticals	Stock Option Common Stock	Grant	Acquire A	No	No	41.39	14,000	579.46 k	14,000
15 May 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	430.93	69	29.73 k	49,691
26 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	425.7	5,034	2.14 mm	49,691
23 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	431.79	4,714	2.04 mm	54,725
21 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	421.77	3,603	1.52 mm	59,439

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.