Patrick R. O'neil

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
16 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.83	7,360	241.63 k	61,203
15 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	19,690	0.00	68,563
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	19,690	0.00	60,724
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	33,000	0.00	80,414
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	22,000	0.00	64,801
2 Jan 25	IONS Ionis Pharmaceuticals	NQSO Common Stock	Grant	Acquire A	No	No	34.69	22,000	763.18 k	22,000
30 Aug 24	IONS Ionis Pharmaceuticals	Common Stock	Other	Acquire J	No	No	38.641	246	9.51 k	48,873
2 Feb 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	49.6738	1,995	99.10 k	48,627
2 Feb 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	49.6738	1,961	97.41 k	48,661
1 Feb 24	IONS Ionis Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	3,820	0.00	50,622

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.