Patrick R. O'neil

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
28 Feb 23	IONS Ionis Pharmaceuticals	Common Stock	Other	Acquire J	No	No	30.515	301	9.19 k	41,882
6 Feb 23	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	40.8648	1,920	78.46 k	41,581
3 Feb 23	IONS Ionis Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	3,822	0.00	43,501
31 Jan 23	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	39.7111	4,500	178.70 k	39,679
30 Jan 23	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	39.416	4,500	177.37 k	44,179
18 Jan 23	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	39.4946	7,836	309.48 k	48,679
17 Jan 23	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	21,871	0.00	56,515
17 Jan 23	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	21,871	0.00	47,655
15 Jan 23	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	17,207	0.00	69,526
15 Jan 23	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	14,338	0.00	25,801

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.