Biller Jonathan

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
11 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	459.87	3,433	1.58 mm	16,330
10 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	467.98	1,632	763.74 k	19,763
4 Feb 25	VRTX Vertex Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	4,744	0.00	21,395
2 Oct 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	461.66	999	461.20 k	16,651
1 Oct 24	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	466.84	630	294.11 k	17,650
12 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	418.77	1,738	727.82 k	18,280
9 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Payment of exercise	Dispose F	No	No	422.74	1,588	671.31 k	20,018
7 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	4,743	0.00	21,606
6 Feb 24	VRTX Vertex Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	6,294	0.00	16,863

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.