Yann Mazabraud

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
15 Apr 24	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	10,000	0.00	10,000
15 Apr 24	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	8,905	0.00	8,905
15 Apr 24	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Sale back to company	Dispose D	No	No	0	6,874	0.00	0
15 Apr 24	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Sale back to company	Dispose D	No	No	0	2,031	0.00	0
14 Apr 24	RYTM Rhythm Pharmaceuticals	Common Stock	Option exercise	Dispose M	No	No	0	10,375	0.00	34,870
14 Apr 24	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	10,375	0.00	31,125
19 Mar 24	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	39.22	16,000	627.52 k	24,495
16 Feb 24	RYTM Rhythm Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	33,750	0.00	40,495
16 Feb 24	RYTM Rhythm Pharmaceuticals	Stock Option Common Stock	Grant	Acquire A	No	No	49.23	67,000	3.30 mm	67,000
16 Feb 24	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	22,000	0.00	22,000

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.