Cadoret-Manier Onaiza

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
6 Feb 23	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	40.6595	1,451	59.00 k	21,227
3 Feb 23	IONS Ionis Pharmaceuticals	Common Stock	Grant	Acquire A	No	No	0	4,140	0.00	22,678
18 Jan 23	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	39.5473	3,748	148.22 k	18,538
17 Jan 23	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	10,197	0.00	22,286
17 Jan 23	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	10,197	0.00	55,326
15 Jan 23	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	19,460	0.00	65,523
15 Jan 23	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	16,216	0.00	28,635
11 Jan 23	VTYX Ventyx Biosciences	Stock Option Common Stock	Grant	Acquire A	No	No	34.16	12,880	439.98 k	12,880

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.