Jennifer Chien

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
11 Nov 24	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	68.43	200	13.69 k	972
11 Nov 24	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	67.5585	11,070	747.87 k	1,172
11 Nov 24	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	66.9484	17,540	1.17 mm	12,242
11 Nov 24	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	65.6763	38,051	2.50 mm	29,782
11 Nov 24	RYTM Rhythm Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	30.66	11,642	356.94 k	67,833
11 Nov 24	RYTM Rhythm Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	24.29	28,717	697.54 k	56,191
11 Nov 24	RYTM Rhythm Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	6.8	20,622	140.23 k	27,474
11 Nov 24	RYTM Rhythm Pharmaceuticals	Stock Option Common Stock	Option exercise	Dispose M	No	No	30.66	11,642	356.94 k	37,108
11 Nov 24	RYTM Rhythm Pharmaceuticals	Stock Option Common Stock	Option exercise	Dispose M	No	No	24.29	28,717	697.54 k	71,283
11 Nov 24	RYTM Rhythm Pharmaceuticals	Stock Option Common Stock	Option exercise	Dispose M	No	No	6.8	20,622	140.23 k	25,790

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.