Debra Durso-Bumpus

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
5 Jul 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	111.2	3,850	428.12 k	43,763
5 Jul 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	Yes	54.13	3,850	208.40 k	47,613
5 Jul 24	BPMC Blueprint Medicines	Stock Option Common Stock	Option exercise	Dispose M	No	Yes	54.13	3,850	208.40 k	0
3 Jul 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	111.29	8,817	981.24 k	43,763
3 Jul 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	Yes	54.13	8,817	477.26 k	52,580
3 Jul 24	BPMC Blueprint Medicines	Stock Option Common Stock	Option exercise	Dispose M	No	Yes	54.13	8,817	477.26 k	3,850
28 Jun 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	111.15	333	37.01 k	43,763
28 Jun 24	BPMC Blueprint Medicines	Common Stock	Option exercise	Acquire M	No	Yes	54.13	333	18.03 k	44,096
28 Jun 24	BPMC Blueprint Medicines	Stock Option Common Stock	Option exercise	Dispose M	No	Yes	54.13	333	18.03 k	12,667
21 Jun 24	BPMC Blueprint Medicines	Common Stock	Sell	Dispose S	No	Yes	102.44	300	30.73 k	43,763

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.