Joseph Baroldi

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
16 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	Yes	No	32.7	1,029	33.65 k	3,071
16 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.7	3,401	111.21 k	25,017
15 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	Yes	No	0	2,460	0.00	4,100
15 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	8,787	0.00	28,418
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	Yes	No	0	2,460	0.00	8,324
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	Yes	No	0	3,750	0.00	10,784
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	8,787	0.00	77,348
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	33,000	0.00	86,135
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	22,000	0.00	51,290
2 Jan 25	IONS Ionis Pharmaceuticals	NQSO Common Stock	Grant	Acquire A	Yes	No	34.69	2,500	86.73 k	2,500

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.