Pamela J. Cramer

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
19 Feb 25	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	57.22	982	56.19 k	19,209
16 Feb 25	RYTM Rhythm Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	3,300	0.00	20,191
16 Feb 25	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	3,300	0.00	9,900
14 Feb 25	RYTM Rhythm Pharmaceuticals	Stock Options Common Stock	Grant	Acquire A	No	No	56.69	30,000	1.70 mm	30,000
14 Feb 25	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	20,000	0.00	20,000
11 Feb 25	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	57.54	3	172.62	16,891
11 Feb 25	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	57.51	698	40.14 k	16,894
9 Feb 25	RYTM Rhythm Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	2,344	0.00	17,592
9 Feb 25	RYTM Rhythm Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	2,344	0.00	2,343
4 Feb 25	RYTM Rhythm Pharmaceuticals	Common Stock	Sell	Dispose S	No	Yes	59.43	902	53.61 k	15,248

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.