Brian Birchler

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
16 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	32.7	5,400	176.58 k	55,051
15 Jan 25	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	14,283	0.00	60,451
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	14,283	0.00	63,090
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	33,000	0.00	77,373
15 Jan 25	IONS Ionis Pharmaceuticals	RSU Common Stock	Grant	Acquire A	No	No	0	22,000	0.00	53,338
2 Jan 25	IONS Ionis Pharmaceuticals	NQSO Common Stock	Grant	Acquire A	No	No	34.69	22,000	763.18 k	22,000
30 Aug 24	IONS Ionis Pharmaceuticals	Common Stock	Other	Acquire J	No	No	38.641	12	463.69	46,168
16 Apr 24	IONS Ionis Pharmaceuticals	Common Stock	Sell	Dispose S	No	No	41.6555	905	37.70 k	46,156
15 Apr 24	IONS Ionis Pharmaceuticals	Common Stock	Option exercise	Acquire M	No	No	0	1,875	0.00	47,061
15 Apr 24	IONS Ionis Pharmaceuticals	RSU Common Stock	Option exercise	Dispose M	No	No	0	1,875	0.00	44,373

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.