NVTA - Earnings call transcript Q4 2017

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Operator

Good afternoon. My name is Christine and I will be your conference operator today. At this time, I would like to welcome everyone to the Invitae’s Fourth Quarter and Year-End 2017 Financial Results Conference Call. All lines have been placed on mute to prevent any background noise. After the speakers’ remarks, there will be a question-and-answer session. you. Thank Instructions] [Operator of you Head conference. begin Investor McNeil, may Relations, your Kate

Kate McNeil

XXXX you, everyone. fourth for year afternoon and quarter call. you full Thank good us Thank operator, for joining and earnings our

Sean Joining our Dr. Bendekgey, Stueland, Robert George, us our Katherine today our Shelly Medical CFO; COO; Officer Guyer, Commercial Chief Chief CEO; our Nussbaum, Lee our and are Officer.

available and as today’s you to on press release As well quarter. encourage have results financial metrics we you which conference listen our call, commentary to the as includes our

within begin, I’d acquire, our accurately plan that prospects, Safe those and Securities operating we integrate therefore investment Act. could to the opportunity, not call like Before demand operations constitute and that timing and to businesses plans our services, products, future services, is including Litigation thereof, our various we our that the from pipeline statements and manage meaning services our remind actual focus demand for remarks differ our about historical, market this financial product our you our of future make we our the and our for our on results, infrastructure strategy, to are results the difficult Private and of It provisions guidance. of reimbursement the of in predict Reform and and forward-looking materially Harbor the business

Risk assumes things for restructurings the we September that XX-Q Factors. titled performances other XXXX, ended don’t additional among to future settlements. legal particular or investments, XX, company We business quarter to any Our acquisitions, guidance refer section on the in our conclude you

These the statements from cause With call factors I'll date our turn to speaks actual only For current results to that of on Sean? differ Sean. could additional over the that, hereof. as materially forward-looking expectations. information

Sean George

to the that in pursue of reap the pursuing genetic mission the technology we've scale. and is of benefits over with the medicine to improve mainstream and of for advantages years comprehensive in you, strategy focused healthcare this on infrastructure planet. investment the bring mission We the an quality past information many to Invitae's billions Kate. Thank people the been on

this year people. and focus experience and have than signed product record mission representing number from than our we organizations accelerating and clinicians of more commercial execution now momentum the system more XXX,XXX ever invested advocacy in with our our is and user of are collaborations, our and for passion business XXXX expanded in Our so on patients both Indeed, partnerships. breath, the commercial XXX enhancement of our our ordering and health we biopharma partnering than more a strategy

As XXXX in in triple testing. cancer the the in provider positive in for the It XXXX we driven this time we're revenue drove digit has exception, driven a volume profit. we primarily and had the explosive past genetic inherited of in cancer was to growth growth revenue. in the And have volume largest XXXX on business year that is no we entire and track past the gross first become indeed and

the and grow exome reproductive working our investments new our to we and pediatric, cardiovascular, as more we're is maternal model forward even as expect metabolic, and business benefits neurological, business Our reap excited health in investment we further. in look past of our

our combined a of In January volume patient Invitae and for on growth the -- out the success XXXX woman gathering the CombiMatrix tracking sales development Good highest In in patients. M&A confidence the XXXX, part in of the launching integrated and their acquired most efforts. a it an simplifying CancerGene Connect all customer network acquired platform to genetic as us gave Genetics we our fall now rolled our focusing January leading on June effort AltaVoice strategy. approaching We we and and part the of with April XXXX in acquired in strong oncology, XXXX, business Our add data XXX% experience of organizations reproductive and XXXX as September to Start and accounts. the as analytics and are counselors as health

healthcare us it's believe foundation. In to in this model, do industry. form I patients about that a little patient profound appropriately benefit foundation and testing. over we the that we the epilepsy industry gone impact BioMarin the they lives. many While whereby would With in adult last little research notice individuals example being cancer it, and by from system management single seek pharmaceutical there access so genetic and spanning diagnosed partnerships. mediated the genetic having world's the spectrum capabilities predominantly children’s behind case genetic by model seal the management An we all new those we using something information of seen in business specific this commercial the of faster year more that information year, whatever information the the We have aggregate the correctly having a as BioMarin the the that early information in parties current entire of on seizer adding from collaborations, on therapies, into be we've We've channel can in build of about more gets advocacy years working past, a be to set a networked that immediately where that individuals that represent and than of before astonishing outcome in platform epilepsy in we ago the can has can who broad testing they’re partnership with the to organizations, partner inherited to a me can interest not with genetic been for benefit program. pediatric doing have out has life. can testing a ever consolidate handed were in and And of lot inherited across the of now Validating a in stages as a pursuing attracted think testing industry. bit

living we With of the send -- course clinicians understand involved, more and the the a patients benefits, epilepsy the underpinnings collectively information about way, more genetic underpinnings benefit Invitae of the they the in having our like particular mission, BioMarin and in commercial taking directly. this endeavor that focusing all the case care of information would genetic not medical aspects into on our major partner be we otherwise

the testing details information and Shelly QX. business this patients of be time Now driver some of with will business testing see testing our network for of the the into part remains number primary business of will business today is details in business, the network QX, business. an contributing To ever-increasing our cover the our of we and the financials Shelly? in the the genetic cover important,

Shelly Guyer

Thanks, Sean.

J.P. Morgan last we on of pulmonary another month, triple in conjunction basis As incredible had a growth in digit conference year with Invitae accession reported volume.

samples on XXXX. basis over Our was samples, XX,XXX quarter total consolidated of volume XXX,XXX accession XXXX the a nearly including in fourth in

Let’s break this down.

our samples, in Good fourth XX,XXX compared quarter reflects XXX,XXX with screening quarter with well services XXXX. volumes business the expanded volume third line annual Excluding our to XXXX revised alone, exceeding XX,XXX Quarter volume associated loss related approximate Start guidance fourth approximately was than full-year of our quarter, acquired in including acquisition, this early our increase in businesses, samples This to of accession samples, samples. the totaled more late XXX% nearly to the quarter accessioned August. an full in XXX,XXX we’ve carrier X,XXX volume a Fourth Volume volume from completed in in expectation. given included the XXX,XXX

accession samples selling the nearly our basis, a in capabilities. As completed X,XXX acquired CombiMatrix in hit all you X,XXX mid-November, In street, On resulting of results. January, quarter quarter CombiMatrix trained our integrated will of sales was amount, recall, included a that doubled acquisition we our total fourth force approximately also in and samples. full

area Going rationale for we simultaneously a performance volume concurrently a working across by practices, forward, clinical be with management supported clinical team number us Overall, or clinical by those in-house. key the progress a we growth a operations for do other efforts to product to metrics specialists. were of provide our acquisitions. future regional significant of with revenue. sales not internal Consequently, warranted our saw on intend utility. areas revenue impact break acquisitions force brought limited all XXXX unified we One a single Last as future or contracts that and unless on platform of in detail any across operationalizing trends category effecting and billing favorable large and offering broad an to basis related savings reimbursement contracts provided a year, issues will and

growth our Morgan Again, conference. per had revenue triple the with another year of we basis J.P. in reported volume, on conjunction revenue. in pulmonary incredible As Invitae digit a

the revenue million, XXXX over $XX million revenue for from increase grew year the quarterly XXX% consolidated the fourth at our XXXX. base the revenue base you Full-year basis, actually right Our On full can full of at total Thus, this in an year sequentially. a $XX.X down, in totaled million. coming base estimates over a exceeded $XX.X basis our revenue. came middle of XXXX a XXX% $XX With revenue the revenue quarter full-year business grew during on business million. see Breaking XX% of guidance XXXX over XXX% at business revenue million. $XX.X year-over-year of and

to Good the the million XXX,XXX revenue the approximately Our excludes prior related Start for to build approximately revenue of $X This quarter. generated acquisition. acquisition in test close

of CombiMatrix The on full-year revenue U.S. the cash GAAP from at decrease included allow fourth-quarter close continue not the in associated the these to go acquisition. of approximately and reported call, the current receivable accounts periods. with revenue weeks last forward our time revenue our in million towards in $X in prior collection, or This the this future discussed not will quarters. of acquisition acquisition's coming impact and this does to representing quarter revenue, recognize count does six test accounting any and us rule amount was close. As the the contributed following to

quarter was million. CombiMatrix As $X.X approximately a point revenue reference full

reduction the to for significant company basis basis market. COGS COGS our and business. ended base and quarter $XXX consolidated reducing a in XX% consolidated business. with XXXX fourth a the reduction XX% for in of to in our accessions, $XXX compares on Turning per year-over-year to COGS, the base approximately in quarter on for This XXXX, a $XXX the third reflecting make tremendous of thereby the the enhancing the cost and advantage sample, $XXX continue year sample We of competitive strides

In addition on over third COGS X% base sequential basis, the a to the business achieved amounted a improvement in quarter. consolidated declines

Francisco we we currently XM the near continue full under expect San as quarter. that out to integration roll the In the CombiMatrix, vary lab including launched we new and operations year to of integration and transfer of last to of our expect through including the quarter way. term, Good COGS As finalize content, Start Good test may improve COGS we Start, to

have we long-term opportunities XX% and In gross reduce longer-term, Looking our of margin. in confident we significant COG our the ability consolidated business. to in synergies sum, realize stated to further remain reach target,

the are critical pleased driving the view collections full our track, right that of we increases profit. down marks We first driving positive products. gross XXXX year indicator, are by on We that profit as a in and gross up

Translates Our the year, basis, the which a achieved a well include from a quarter revenue, XXXX. gross the $X.X fourth this million, business. gross of base base from significant $XX.X Invitae increase on from a gross XX%, on in a million as the consolidated a third compares million for XX% fourth to base million gross gross quarter basis the of in a profit from XX% the test $X.X of of NV to million included consolidated profit $XX.X quarter, margin revenue this consolidated increased in fourth million of profit test $X.X in loss XXXX. as profit gross XXXX, business, In the quarter or margin to test of up of business $X.X the

million corresponding XXX%. administrative Start to costs and year-over-year CombiMatrix by were operating XX% general of were of leverage year in excluding which Good expenses, a fourth increase operating against In XXXX, were $X we increase Improvements full million offset to the million base excluding in improve. expenses marketing intangible costs the selling about of $XXX were expenses increase on acquisition these Despite business drove leverage the in XX% and operating business expense our XX%. of expenses XXX% XX% and and continues related amortization $XX.X while to This higher incurred compared basis a consolidated For volume and development COGS and to AltaVoice approximately operating related $XXX.X for $XX.X and research an nearly the we limiting to in the and expenses. growth COGS base million for the quarter, in incurred earnout. XX% a We in XXXX, million volume increases

$X.X in operating amortization expenses and amortization expenses fourth million consisting stock-based approximately completed in intangibles quarter’s the increase equaling will XXXX. a acquisitions non-cash intangibles of final quarter due million this of equipment million CombiMatrix. million $X.X beginning be P&L. first four $X of the reflecting amortization the in to should full quarter, comp. quarter million of and We anticipate in of approximately Depreciation included understand X.X to For in that XXXX Two make $X.X point

First, there third $X.X estimate we the of Start numbers the a acquisition. based Good million quarter been provisionally on the available. In recorded the was third the due benefit reversal to made tax quarter, in an

deferred accelerated corrected deductions. deferred tax start As by tax equal the assets. use goodwill in $X.X by the This quarter, and method non-accrual million assets fourth of million. our an tax closely we $X.X experience In adjusted experts to look the more

share include their Second, weighted per the average shares. of quarter effects, net year not shares shares and XX loss preferred for the shares the does our full thus used million the dilutive million were competing the XX.X due non-voting fourth and average used for share weighted to number

balance items. Moving and sheet to our non-cash

worth in fourth an for expected, It’s to $XX.X to expenses, our in Adjusting fourth included noting increase burn XXXX burn to million. the to acquisition. saw our $XX.X related total related million closer quarter which charges As one-time that close we acquisition quarter for $X.X this million.

integrated versus business million cash was again in Looking third acquisition costs, $XX.X closely burn million the at more the $XX.X quarter approximately quarter. fourth base excluding

While, integration associate we decrease continued in next over few burn will quarters, cash business aggregate the base the the burn and will by anticipate our reduction offset modestly with by partially burn believe the the the reduced. positively CombiMatrix of that cash flow longer dramatically more and will that to we our and cash be expenses. Good will In acquisitions term, Start contribute

the to year attention ahead. our Turning

least reflects XXX that course Likewise, million There announced, and accessioning expect expectations have impact revenue to XXX,XXX a we sight reflecting growth we in the our of XXXX. quarter. believe line to the anticipate least fourth double numerous XXXX. for continued previously we strong of This run double-digit at As at in samples growth variable revenue over on XXXX XXXX. could revenue in achieved favorably rate is clear

However, timing. externally in each probability, of own magnitude and care or the largely driven calculation of

year. including guidance on implementation to, current result, we a limited are but until to reimbursement future These contracts. certainly we visibility include, factors have As improvements and are impact, our of payer clear related not these for the continued third party

increases to to ability dup networks. build in codes and partners Our and non-test revenue related new CMS for patient del

As and we contracts is have have time believe we approximately of of unprecedented signed in the contracted is price equal of on $XXXX. a breadth contract complexity amounts said, year, That test these discussing operationalizing many spent the platform. these what codes the our rate covering of have prior we discussed party the reflected average of for The payer we contracts the length third an XXXX.

contracts to the we improving average reimbursement priority year, of significant be have of these the course continues reimbursement the for rates under increased, seen us. Over a past

this our hand, our revenue based practice codes for modeling of breadth than on test. improved rather Similarly, current reimbursement of we therefore much we historically prevented rates. out trends dup with However panel associated been and of from building del mentioned CMS forecasting are

even our our about XX% per approximately would Based current billings of volume apparently mass, billing within analysis allow have add CMS our dup volume. revenue. uniformly del for not $XXXin mass up reimbursement revenue we efforts rates, in stepped CMS test to conjunction conducted of our is with on size all to for nor this panel del across As own and dup historically

discussed, partners Sean number coming we increase of as within network looking have year. our are to the the in Finally,

revenue, upside number both While we see could non-test model networks. the we involve patient seeking rate as of volume at greatly this form activity increased partners to as hybrid accelerate, opportunity the drives revenue well Depending expansion well of as creation forecasted we see both revenue. currently in the test meaningful as testing partnership on the which see to or that increase of sponsor solutions

Sean George

you, Thank Shelly.

work to line improve indicator can trailing and revenue of drive time-in our our important continue gross a profit, focus that the an from a trends you be revenue And as optimistic made will indeed volume. diligently operating around volume as leading efforts are of drive we we as and the So, COGs to business. Shelly of quarter-to-quarter. our real on while, continually about to success down covered also expenses ability and see, indicator reimbursement to

We and in of operating reach margins platform. ability driving steadily of gross we across in as confident to such as improve margins XX% XXX% this the And are approach and the business maintain this the our surely profitability. volume,

context to the with volume instead information wellness look of is their in at other forming family forming to context an it how in of other questioned life, and individual lead spreading to we or stages circle information is the across specific way as disease family in to a answer our genetic of in further can our and at Another but larger of consider answers to as have genetic capabilities or interested importance information some larger in of the life is that and large. question it later all too Whereas of of think on a is, about into fact seeking whether generally health in information important context stages life our just life were. in their with even population partners being

evolved of calculated in in this industry the it, outcomes of be I've go is way industry. the the we an testing And as In the it, of largest know information suggesting this that ourselves in generated in with across that beginning at powerful comprehensive inflection of used us value gets that the at is that the We to quality will the Invitae two skills quoted how quality participants, number that at cusp across side to network genetic their we clinicians individual been capabilities certainly ever-increasing importantly personalized network the for one with all the most wealth we all of of and across revenue patients information be affecting individuals us. other are since ever-increasing system highest high the the valuable, long the connected of highest has can dead. data an highly increasing partners used the we’ll can by number largest more them, enter information comprehensive genetic these that It targeted bring genetic can and and and that believe every with true offer that of individuals, where are ever-increasing that can in would the human approach individuals dawn of industry data. fashion, network genome side the network enters accessing working is And all genetic I can setup the their people with the on set whole. We the seen for indeed is based amount working the medicine. are improve true of on access information more be question. set the value a information most instead, served, unleashed for across partners project stages think whenever it of specific the quality of valuable number the and an healthcare partners entire becomes effect more into and who and life.

Operator

Schenkel line question [Operator from Thank Company. Cowen Your first Doug Instructions] the you. from of & comes

is Your open. line

Adam Wieschhaus

on Thanks is Adam questions. my for taking Hi, guys. Doug. This Wieschhaus for

I proponent help and question, Invitae first test is, recently provide the how in volumes approach a further share, the elasticity payers price forward, can certain discussed the seems prices any and the established possibility your step guess, you've on is next my drive has if marketplace, providers? believe long in that market indeed you color my question in it that so received driving lowering I to case, of so, of like being even by is So been instances

Sean George

the unmet is over the mechanism Sure. The market that short a as we've commercial been price meet the tool. size little a four and over is, demand past, definitely answer since yes, indeed increase of years, to a the

this perhaps did our I probably is to felt our as expand just $XXX. the -- on we insurance particularly outside directly understand business expand will information a help that demand even the understood think access to we and This into this question enjoying we reimbursement our on into can have business, your guidelines else, from and is supply well, believe as genetic in as becoming pricing this have our make. answering as scaled in that our people the we this both more make data and in price specifically the individuals we think move, a bring most for and criteria, more we And individuals, community month and come everybody to economies market of we testing much to and certainly as need side is, panel move patient $XXX and clinical lower widely move a network. we this hope services scale testing pay move

we this to in feel point comments time in beating that. Shelly price at the point this change industry and have third-party plans On the any reimbursement, mentioned run we at or time, that $X,XXX contract is for have to don’t whole,

criteria, time. mentioned integrated price, large exchange have of reimbursement kind -- if that, plans at do in in no that be upon, past on for system this take We in the payer we to a point or expanding to have do would specific us our interested a so would large but

Adam Wieschhaus

trade for has to weeks, is your of few that Okay, the Maybe will over in be discussion, indicated price volume, think specifically, the changed past anything guidance, thank that same? you. more I you you kind issuing or willing

Sean George

fees, change of accordingly. forecasted so real strategic there, last we've guidance think key for that's pointing no been commercial end been kind I pulling and out a on probably no No, worth X.X change years our lever a as

year upside the it kind that covered take case and we win and could as everybody the to and trying to inform together -- forecast what think opposed to to happen magnitude. things this again we as of to Shelly a experienced and to happening I we detail want that the see

Operator

question JPMorgan, is from Peterson comes open. next your from Your the line Tycho

Unidentified Analyst

the Hey thanks is on question, actually for taking this Julia Tycho. for

one on the and believe into focus of maternal you if mentioned lower move that, months. I the increasingly centers expecting given driving is, volume So, over health volume next like guys you the previously some are XX first my customers, to

on it could a takes cost just could continuing hurdles at more the benefit just over if awareness move? the move high-volume effort what to if and so a little So than wondering you bit, over comment are you. bit a customers of such customers, behind you assuming on and the Thank rather of on get comment rationale forces focusing little play, the there, sort the the competitive behind to

Sean George

Sure, acquired. volume are the sales highest reproductive businesses health clarify, the concert for oncology organizations thanks question, in in the we working the together and while They from and health. to accounts indeed have just and reproductive combined across women's we

us So, feel to in inherited, and aid to efforts reproductive plenty all direct in from adult there in we way still way we life continue across to this where those of the our our left accounts space. of all volume really all augment continue stages the commercial will and high-volume upside is the think offering the the breadth

market plenty of headway there's there. accounts make these just continue high-volume still and again think So, to expect to in restate, we to

Unidentified Analyst

the on about cost second side, a been lot And so understand, spending then given one on down the my XM offering. it. you drive medical especially talking interpretation to the COGS got side, Okay, your recent have

and a investments maybe more So, of are go the think that you much the wrong terms do are it how much in how resulted progress color specific you and making making you there ahead? has on give you reduction way bit of could will little the COGS

Sean George

in. same disease that high of augmented evaluations worth if have that on and the X,XXX the last our ever-increasing a out able I taking interpretation couple with time kind matter look on of teams So, in of engage teams backdrop at think that a it processes and business, and software to process COGS the will kind the over slides probably it's at growth see with the in difficult it as our specialized lot automation particular the on The say again is drop the and new words, be same lot a very, very until I into specifics you been line, continue it development can this assessments to side, list growing of the we an software the investment and years past a again this of scales you number think of take long years. are we out is convey making been taking a COGS have the possibly highly quarterly would able as volume rapid but I important really picture's call, of engaging very operating and areas the been actually against a as been a in we’ve quality in such, by on can be lot of it’s up really business. a to that and I as and investing our actually action, of challenges more have operating lining are many think as COGS and that have to volume even costs automation we And been can associated and we get presented medical

Unidentified Analyst

for one last And me.

by potential as potential or revenue the many of partners growth kind partnership guys whether not this and currently source may require of about screening for they talk out of You you capability. to your alternative additional understand agree and using that you’re partners

you’re could address you fill So to these to and just do to if we partner looking the bringing issues these hurdles any capability a bit revenue potential how gaps partners look your comment that you of side the as wondering over about and side? from potential upside

Sean George

Yes.

we time. Katherine can the way partnerships think is there anything we patients control is phone, information in do believe the menu we she little of can said, some at past, in on that content us of own color alluding space. these. than more their think actually in on probably not I outlook bottom-line our pursing in to you’re is the partnering Katherine there is and there. think indeed can the I a chase because expressively I working partners But for the the concur point with I more have our have with a give is this blocker

Katherine Stueland

to. happy be I’ll

more to spring, complete last of testing that positive partnering in even and be biopharma a position introduce able particularly when rare space. disease to more companies As with we the in us put start menu really

taking it a shares to mission current patients comes a So, of diagnosed being really at able drugs our find our look sooner. in that menu, partner are helping development what get and to testing down

comes thriving really and most being AMA content So down for it of the finding driver partnerships key and us BioMarin others. to the like

I of build-up genetics lot together as we rollout genetics to raise the and based ways to able or think that of see to capability rule work we forward utility being to on awareness So, in continue of as disease find prognosis. we moving earlier a opportunity to and continue a

Operator

of line Souda Your next Puneet from the from comes Partners. Leerink question

is line open. Your

Puneet Souda

how the same guide that as contracts how with and in business? into me we question clarity three-year your much And business think should sense base, think is expectation. if Could we of reproductive trending about the contracts? the part So, of and could provide as the the provide about -- on guide? what’s business you year, the locked volume was the hereditary base as, guide current in should as which your commercial How of what’s well last soon you part now the terms of

Sean George

to answer it don't essentially talk perspective. I'd the the approaching because with number, appreciate bulk the time from this is the $XXX anymore first of point in-network in is So, we're reading up, more an it at and you're we a question north basically about accomplished million of standouts few lives covered actually say now

collectability the potential momentum relates in again revenue each translates of the X businesses, to than the movers through for as we growth numbers the anticipate then kind is from in we I business areas will at platform perspective, revenue think the on profit differences line and year. a experiencing And what throughout As think for across kind walk volume I gross contribution or the collectability the X or out the look a it fold a to and outlook all ASP Shelly but upside all on break the an that. or don't ASP on on where year's

Shelly Guyer

our and forward. of do the are continuum it forward. breakout looking business just of It's intention all parts push as all intention one force a really all not as I moving content. the Because view to them to that's not and interrelated sales our different we products indicated as Yeah

And circle so, is forward. moving as Sean that plan the explained in as talked before and his we've

you're out much be year. to the $XXX,XXX at the to and not best is volume, we attributable is how will so, old And business breaking asking much attributable next for for the how reproductive.

Puneet Souda

me if understand Sure. of guide $XXX terms help million. in And you the can maybe just revenue the

you'll understand maybe us Help have ASP I potentially could $XXX perspective. at here more of you'll a when in on number conservative why here? a million Help an volume us here. a us be rather to giving clarity reasons think maybe you range the you from more understand when that from have think do that from have than clarity of the least provide You're just clarity realistic that

Shelly Guyer

was think last Because numbers. of these you do on specific each when little we specific I to on that that tell occur. quarters year that they not each of our work of these a give Well, in bit. And off will we will anticipate do intention And discussed. have guidance bit this fact we we year

that project hope We not they when will occur. would we

that those hard higher numbers exploit very it's will But will as anyone fast how for hard to As from of very of machinations is to the paid how when That predict the of work the instance anyone try offer and contracted work up. and a can through when related and through flip of are payers higher to will is continue all or hard as we out indicated, of percent predict getting to anything bring we much change and a to them hands to under to each rigorously to rates. possible can flip percentage our significant those many payment. they prior

don't want predict that to And perspective, so, from timeframe. any specific we

dup the movement very As also CMS del also there. may predict mentioned, are they on working have situation. with when some we that's And to hard

you will happen. let will we when they things those know may we when happen, on that not we forward So, hope project would

Sean George

in as multimillion assure you I bluebird can that single issue that’s of I it than and margin CMS the to -- we industry anytime the a we And some we us. that, dollar profit in again And business works, by it no have we’ll dominate gross take the we're line the and the so to we're our show not in of absolute year reimbursement years one maybe performance become that, more are to thus, me pop come. the come. time, even in -- is mode that longer-term, have our quarterly frustrated improvement why is only the our I again to mean item to a keep realize, can just confident in an model, confidence is will or may answer quarters we look accustomed think in operating continued in kind but understand and

Puneet Souda

your the that helpful. in and prep have, are that control, very Bioinformatics That’s Okay. And other of things and sample and I terms of the just in improvements improvement, one done. the have parts under pipeline COGS you instrumentation last

out there, XX% margin, then that new So, to timing confident about that still the the does the how an and this you understand new business profitability somewhat? guy very it gross push profitability, driving and are you're us on thinking looks potentially like help just just expectation with

Sean George

Yeah.

go across when I'll timing and to parts to a margin COGS is improvements, Again, the moving back many the those into COGS we then services first, look of come to XX% very So, on different the platform let’s gross our profitability. lot there.

forecasting on particularly in balance the is and can won't exact the all we the course timing against general managing there acquisitions then that a and the our business. of just in. our inherited volume efforts, on Lee perhaps look So, give be backdrop of the

Lee Bendekgey

Sure.

we separate that running the of of of screen Good PGS think in well Start. as from carrier been has extended I Cambridge -- year, opportunities And in capital. an the the terms Start up see had assay the lots half Puneet, acquisitions In PGS we're first bringing as as the of aware, former as and a you're Good both the assay probably CombiMatrix at lack

of And so, were it’s as result - kind the as - subscale. they well

are particular run scalability invest NGS-based and the based of lower And on PGS volume, the single those runs which - a and consolidated Ervine. assay has volume force sales as so, microarray to assay the from Good in the in the there opportunity PGS consolidating the assay, assays considerably than drives opportunities the -- Start in COGS

both that non-lab So, lots COGS opportunities with to are related. work usual are and of lab laundry along those But the on. we the some see there, acquisition of list COGS of highlights

Operator

comes question the Murphy of from Blair. William next Your from line Amanda

Your line is open.

Unidentified Analyst

Hi, is Amanda. for you my question. Thank actually this for taking Max on

good whether managed Exome Just wanted seems contracts bit include to Exome the reimbursement, particular volume, sequencing. sequencing little about percentage as a general in care a such as big context and total to whether reimbursement particular of it your that some ask tests Exon represents new sequencing, for how and in just

appreciate for things So, there, in just Exome sequencing context that general? a would I few

Sean George

sense volume we because breaking rest. looks answering you Again, pretty carrier dialogue will Again, payers, ever or with amounts we I it reimbursement for surprisingly I contributes of reimbursement like it be its won't great versus the is new reimbursement in profit patients a fast is but breaking quickly, is high are of it's think perspective so optimistic particularly With with the that fair the the set can business be we advancing, worked there with can Exome, increasingly amount really fairly going business and the be ask gross great, are we come think good. a company these think actually level. an years the our it. advent payers and to lot the or that part is contribution last won't much potential profit out, said, so for no reproductive potential kind in coming best say and does gross from criteria, still criteria the out is of be questions Exome our I is I much platform to we that forward, Exome a couple answer of having Exome other said, that from still the this work today you in we test clinicians, is Exome, has in expectation. our doing the a the you where get our for payers and that as run and what the that like not so. are out out description which details, over the high, so will But, would for The the being by meantime

Unidentified Analyst

or then still the look changes of very but were negative what around Appreciate now into not, to preliminary helpful. want And probably both are key thoughts whether bit wanted any NDS NGS kind see an positive the to I the more from effects to of rule, ask are following higher a about, ourselves, unrelated things Medicare's the context, XX-day this those your at events? that's I seen you ripple up, or or level. have and a on

Sean George

think those influx, of that well understand final our of day-to-day neither in is, has and an immediate say, we'll discernible the of changing -- there. rapidly dual elsewhere I'll that a Yeah, conversation that's out effect Those nor one, comes entities, is our we business. track that two things I hear is something with continue and neither kind kind everybody we are

XX-day puts had, in immediate business. a when not of I I an ball think for mostly our our has nor lot that's takes rule, a it's day-to-day it’s it do aspect point side the and to the our not time. but The business inside of billing impact that with Medicare something going at on that is on lot business, of and kind other clients, in content again, that impact say So effect have of operating material of an this got that’s on in all something the our like it's

Operator

Thalmann. of from the Your DeGeeter Ladenburg comes from next question Kevin line

is open. Your line

Kevin DeGeeter

target to has regard the accelerate way Invitae's the the characteristics margins and or gross questions. hereditary my hereditary price guys. higher use With the side, in afternoon should different as drive Thanks to and for on than both for business, good cancer? which there's CombiMatrix see reported somewhat cancer. taking scale level Hey to a reported historically the about that market elasticity having you Do reaching think an business opportunity to as we that microarray

Sean George

able a note fact I of which think the pursued we CombiMatrix, kind microarrays is current replacement I to number better from right we to in be which essentially all even and development, the down we Exome benefit and cytogenic in particularly that at individuals our, in pediatric we’ll and COGS had of an specificity of better driving it increase way while CMA will in made No, produce to NGS disorders bringing technology think are fact in when sensitivity, online, that's a type look analysis testing. for according we that first

I think I we if overall, do think the available panel some that’s he think kind say and personal a think is broad maybe high level dynamic yes, a comment, just Dr. of I just that there general is I’d and of in the CMA of potential exome disease Nussbaum that exists. there So, is very answer particular in combination type markets utilized how And can view strengths this the course today. of of of testing,

Robert Nussbaum

who are tests plan very is going together ask whole intellectual the exome the have answers, testing developmental to pleased full intellectual at both and going other provide range or give delay extremely that includes of evaluation CMA that the and Invitae's developmental questions level disability They be important forward they delay level. very both children and to the for each testing different of disability. I’m or different particularly for So, complement

Kevin DeGeeter

an one women's prenatal the the side think to provide update related menu about just with expansion just when hear how for of more health to, maybe and business? you Can more then And may we regard Terrific. follow-on. about

Sean George

Yes.

potentially the of I think as space in and this NIPT as we’ve kind then talked kind of year. offer about fill ECS of the in adding a

nothing working course that to external messaging. mentioned in at of the would we’re There as is time, this we’ve of our half or indicate of get kind year. that as think possible statement of I first any aspiration quickly this refinement point in

Operator

are Kate at questions There to McNeil, turn you. audio time. the further I call back over this no

Kate McNeil

Thank you.

call up, had of the introduced before online Couple a Q&A our of of afternoon. questions $XXX this patient get the new, covered already which quickly we been around analyst advance the and the including Just recently couple submitted have from details ramp we pricing. like questions through some pay

However, do year. also that in three follow-on we came with does want months income to us just the tests, we related two that are that volume how for asking next clarity’s sake, our we more the do more question that questions have for turn losses in inquiring within mean test the if in about

maybe Sean, you So, can...

Sean George

clear increments, business very Sure. Absolutely. we’ve something about And doesn’t I day team may months that of from I and think three this, tend truly to certainly think one. kind our in don’t relationship will the admit. I it's

the And the balance On other of questions I see just inflection indeed, to look incredible profitability operating think drive forward interesting us profit line. contributes basis against a opportunities is growing And step that front in will a in balance volume demonstrated on an aggressively this build have as pull opportunity then profit. profitability gross what happen. And think lot test watch to variety that utilizing And making a company way profit volume. to business. overall at per profitability. with to can gross of we’re every that expenses get valuable when is that in point profit equation by margin will is on past, that investment an profitability we the because of the of of immensely the against again, we there inherent I And grow and positive definition gross that And the we a of that back something is positive that kind and subsequent the test, us, business. to drives gross gross the simplest of we as take hand, faster are a we we driving are the

at efforts maintain volume I So, in and a factor little of our being so. short, gross in able do confidence so to length we've can kind discussed of and we helps as profit continued here a bit long think

Shelly Guyer

Great, all it looks questions we like that received online. that actually covers the

So.

Sean George

that Thank look all questions. at you your Well again conferences. call. participation for you thank will the upcoming seeing close Great. to for And forward we you

Operator

This concludes today's conference call.

You may now disconnect.

Invitae (NVTAQ) 12 Feb 182017 Q4 Earnings call transcript