morning. Thank you, Rob. Good
excellent the have dedicated science increase to exceptional is billion execution across XXXX strong colleagues revenues both value earnings. our XX%. billion, contributed start As very company our focus Rob that LAGEVRIO of an revenue. strategy, Total investors. had enabled by innovation were customers the with results for of in patients, $XX.X performance and These and revenues $X.X core globe, of delivering on highlighted, a in our further demonstrate and at we
on Excluding strong base of remainder business comments XX%. my growth LAGEVRIO, ex-exchange will The an the delivered be very of basis.
its momentum. health Our strong business human continued
XX% pillars well the the health primarily as as reduced of human the grew pandemic. key driven LAGEVRIO, Excluding by our impact business
sales segments. business Health above-market driven X% delivered companion livestock Animal Our with by performance increasing growth also and across animals both
expand continues quarter first from the continued to robust and In to U.S., KEYNOTE-XXX. in to excited on brands. indications. adjuvant and In strong earlier currently approved in key earlier renal the across grew demonstrate launches XX% about is melanoma. carcinoma the triple-negative benefiting of all KEYTRUDA the turning our new cancers, data KEYTRUDA is oncology, growth KEYTRUDA cell breast, billion, including from indications treat $X.X are cancer we lung five performance potential and expansion into encouraging to the Now and tumors key opportunity global stage cancers, recent reflecting based to stage demand into
the ongoing launches cancer, inhibitor. renal KEYTRUDA's be XX the and carcinoma. We growth in X KEYTRUDA benefit position In to experience be leadership clinical new lung early-stage and lung combined cell the metastatic patients. to neck KEYTRUDA's disease. market-leading will and familiarity Outside continues in patient the Lynparza that continue its continues to and data, and with capturing driven eligible U.S., confident physicians' expanded with support out robust remains by cell of cancer cancer head in use the setting, product, maintain non-small PARP
grew cancer. alliance revenue in breast by XX%, driven Our metastatic uptake
we reaching We recent on study. launches in new OlympiA driven to based are endometrial renal we revenue carcinoma onetime potentially types. certain trends based are in also growth excited also across strong cancer, encouraging and items. stage of these tumor of had hepatocellular KEYNOTE-XXX broad in advanced cancer, look Lenvima China benefited by on following PROPEL breast alliance where by carcinoma FDA demand from the KEYNOTE-XXX increased each growth study. and Further, in opportunity approval following expanded the also cell metastatic prostate Lenvima very early the share forward seeing in the population the a patient uptake
among patients tumors. by and strong patients. excited are certain WELIREG We continues of leaders, with the providers launch WELIREG also generate to VHL-associated for interest scientific
still WELIREG these uptake, strong Although launch, treatment need for its patients. providing option had a significant has the unmet in to early
future. extend We in indications are working broader to reach potentially to RCC the its
demand led due by key in vaccines remains Global and the again CDC to demand portfolio growth underlying to billion. across China increased supply. performance XX% for geographies GARDASIL, during increased to which particularly vaccine acute the by the the portfolio, excellent Outside care as quarter driven U.S., In strong as data strong as BRIDION U.S., of was females timing that recognition procedures the support can GARDASIL the significant delivered real-world clinical of sales blockade GARDASIL and the $X.X practices. by driven Our well in reversal increased well strong prevent our grew class. cancers efforts continued sales agent certain help of hospital neuromuscular recovery increase leadership and both as HPV-related as In and a in males. ongoing surgical XX%, robust
of demand remainder Gross in through a primarily percentage of as Animal well LAGEVRIO now XX.X%, vaccines. be and robust parasiticides, our X%. to basis. X% P&L, sales driven of business points, decrease delivered increased with poultry. sales non-GAAP on Our sales. the you driven of including growth, line the and products higher sales another Companion X.X higher by ruminant BRAVECTO by Health I animal quarter will will walk margin global was in increased comments due demand XX%, as Livestock a increasing my
expense and reflected within favorable LAGEVRIO is we with Gross Ridgeback, impact product our our higher cost profits gross quarter $XXX behind reduces invest X% As approximately equally million. margin also increased expenses by was growth we this from share reflects drivers billion to reminder, of our Operating a sales to continue percentage. offset which and costs. as of margin Other manufacturing pipeline. prudently partner mix, $X.X
was Our tax rate XX%.
Taken share. $X.XX we earned per together,
Turning guidance. XXXX non-GAAP now to our
industry, certain our As at reporting. ours, to made changes including non-GAAP have the request a SEC, the reminder, of companies in
results. as and longer to We acquisitions milestone will exclude non-GAAP licensing transactions significant accounted as related for no from payments asset as for agreements upfront and expenses collaborations well
of non-GAAP in included There result, of R&D XXXX. charges a billion XXXX of non-GAAP recast acquisition XXXX and related was As by quarters results. by and the expense Pandion $X.X are no This billion primarily to the increased R&D impact our EPS now $X.X decreased to first $X.XX.
from Our does have assume any excluded transactions would significant been not XXXX that previously non-GAAP. guidance
exchange our quarters The execute raise of strategic full foreign over million excluding rates, growth priority. could change to us if full an business narrow using which in year to representing in between $XX.X X%. now includes projected future impact of impact XX% is impact revenue exchange. The negative our development guidance. and we enables or from We from the be to approximately of foreign So $XXX just underlying expect XX% strength to business incremental a XX% resulting mid-April a $XX.X and billion year XX%, of and LAGEVRIO billion, this headwind
our We margin XX.X%. between XX% gross are to and increasing expectation
of billion. We operating At with to midpoint, $XX.X by the was implied expect this what consistent prior expenses billion guidance. $XX.X is our
of an taxes paid expense XX.X% other U.S. We increase assume million. tax full outstanding. shares to rate expect approximately billion We income. year be We between X.XX due to assume and on XX.X% estimated a foreign in $XXX
headwind the tax together, EPS of key foreign slight operating have in strength part increase by LAGEVRIO we expected from range from using an to rates. pull-through incremental in and Taken $X.XX, our X% our our offset a operational pillars the increased assumption, sales in of mid-April rate our end $X.XX top expense the to reduction exchange and representing leverage,
your on. to there you consider few a As focus are models, areas
we narrowing range billion. full $X.X First, guidance the of $X our to billion are LAGEVRIO, on to year
We supply therapy, of have million the million including for therapy. X agreements entered in approximately purchase into XX authorization, and quarter. courses million of delivered courses X.X first we Since
the half quarter. revenue full in of from We the year remaining expect second LAGEVRIO approximately
for We especially China. continue ex-U.S. in including markets, GARDASIL, annual strong to growth expect
line a COVID the for approximately in revenue completion million and out-licensing benefited other as Johnson Other quarter contains began we included are also items, Also first of and receipts Finally, from spin-off $XXX Johnson its in to year Organon, revenue & revenue relating our reminder, which hedge last supply upon the to agreement. recording including sales the royalties. vaccine. to our several
unchanged. priorities Our capital remain allocation
we continue prioritize to pipeline to in business First, and will investments long-term and near- our growth. drive
strategic of time. pipeline the over continue to and we be development, through additional To internal it opportunities. value-enhancing will committed with to dividend goal We remain intend in the appropriately to our aggressive our share augmenting will the it shareholders by We for growth we increasing our business the in demand global and to extent, cash, we business, To confident have vaccines. the return we of very excess conclude, through repurchases. remain medicines innovative pursue driven
that, turn We position to future. deliver of us to to and execution well call patients are the and our over With our I'd operational into in a continued Dean. value will now shareholders to strength the enable financial and like